phenacetin has been researched along with Methemoglobinemia in 40 studies
Saridon: contains phenacetin, caffeine, propyphenazone & pyrithyldione
Methemoglobinemia: The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenacetin has been used as an analgesic antipyretic but has now been withdrawn from the market due to adverse effects such as methemoglobinemia and renal failure." | 7.78 | Metabolic activation by human arylacetamide deacetylase, CYP2E1, and CYP1A2 causes phenacetin-induced methemoglobinemia. ( Fukami, T; Higuchi, R; Kobayashi, Y; Nakajima, M; Yokoi, T, 2012) |
| "Oral pretreatment with diethyldithiocarbamate (DTC) and carbon disulfide (CS2) prevented mice from methemoglobinemia induced by phenacetin." | 7.67 | Suppression of phenacetin-induced methemoglobinemia by diethyldithiocarbamate and carbon disulfide and its relation to phenacetin metabolism in mice. ( Masuda, Y; Nakayama, N, 1985) |
| "Phenacetin-induced sulfhemoglobinemia was diagnosed in a middle-aged woman with a 6-month history of cyanosis and a 10-year history of ingestion of analgesics." | 7.65 | Phenacetin-induced sulfhemoglobinemia: report of a case and review of the literature. ( Kitchens, CS; Kneezel, LD, 1976) |
| "Phenacetin has been used as an analgesic antipyretic but has now been withdrawn from the market due to adverse effects such as methemoglobinemia and renal failure." | 3.78 | Metabolic activation by human arylacetamide deacetylase, CYP2E1, and CYP1A2 causes phenacetin-induced methemoglobinemia. ( Fukami, T; Higuchi, R; Kobayashi, Y; Nakajima, M; Yokoi, T, 2012) |
| "Oral pretreatment with diethyldithiocarbamate (DTC) and carbon disulfide (CS2) prevented mice from methemoglobinemia induced by phenacetin." | 3.67 | Suppression of phenacetin-induced methemoglobinemia by diethyldithiocarbamate and carbon disulfide and its relation to phenacetin metabolism in mice. ( Masuda, Y; Nakayama, N, 1985) |
| "Phenacetin-induced sulfhemoglobinemia was diagnosed in a middle-aged woman with a 6-month history of cyanosis and a 10-year history of ingestion of analgesics." | 3.65 | Phenacetin-induced sulfhemoglobinemia: report of a case and review of the literature. ( Kitchens, CS; Kneezel, LD, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 39 (97.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (2.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kobayashi, Y | 1 |
| Fukami, T | 1 |
| Higuchi, R | 1 |
| Nakajima, M | 1 |
| Yokoi, T | 1 |
| ZEGARSKI, W | 1 |
| SZULCZYNSKA, K | 1 |
| GILMAN, A | 1 |
| PANZRAM, G | 1 |
| MONTOYA, C | 1 |
| VOLOSKY, R | 1 |
| KEEP, VR | 1 |
| ROSS, JD | 1 |
| CICCARELLI, RF | 1 |
| GAD, I | 1 |
| JACOBSEN, E | 1 |
| MADSEN, S | 1 |
| SCHMITH, K | 1 |
| MERLEVEDE, E | 1 |
| DINES, DE | 1 |
| Shahidi, NT | 4 |
| Büch, H | 2 |
| Gerhards, W | 1 |
| Karachristianidis, G | 1 |
| Pfleger, K | 1 |
| Rummel, W | 1 |
| Skakun, NP | 1 |
| Shendevitskiĭ, VI | 1 |
| Gordon-Smith, EC | 1 |
| Muller, A | 1 |
| Laugner, B | 1 |
| Reiss, F | 1 |
| Stanulović, M | 2 |
| Popović, K | 2 |
| Borota, R | 1 |
| Cvetić, L | 1 |
| Efremov, G | 1 |
| Kneezel, LD | 1 |
| Kitchens, CS | 1 |
| Margetts, G | 1 |
| Goedde, HW | 1 |
| Kuriyama, K | 1 |
| Schmitter, CR | 1 |
| Imai, K | 1 |
| Matsuura, M | 1 |
| Furukawa, H | 1 |
| Hayashi, Y | 1 |
| Nakayama, N | 1 |
| Masuda, Y | 1 |
| Yokota, K | 1 |
| Izumi, N | 1 |
| Kumagai, T | 1 |
| Lagadec, B | 1 |
| Liguory, C | 1 |
| Graisely, B | 1 |
| Debray, J | 1 |
| Krulik, M | 1 |
| Galand, C | 1 |
| Boivin, P | 1 |
| La Du, BN | 1 |
| Easley, JL | 1 |
| Condon, BF | 1 |
| Du, BN | 1 |
| Fariss, BL | 1 |
| Knochel, JP | 1 |
| Nolla Panades, R | 1 |
| Fernández-Nogues, F | 1 |
| Peters, G | 1 |
| Baechtold-Fowler, N | 1 |
| Bonjour, JP | 1 |
| Chométy-Diézi, F | 1 |
| Filloux, B | 1 |
| Guidoux, R | 1 |
| Guignard, JP | 1 |
| Peters-Haefeli, L | 1 |
| Roch-Ramel, F | 1 |
| Schelling, JL | 1 |
| Hedinger, C | 1 |
| Weber, E | 1 |
| Fraser, IM | 1 |
| Tilton, BE | 1 |
| Vesell, ES | 1 |
| Weber, A | 1 |
| Patané, S | 1 |
| Cannavà, N | 1 |
| Ciaceri, G | 1 |
| Buzello, W | 1 |
| Heymann, E | 1 |
| Krisch, K | 1 |
| Hemaidan, A | 1 |
| Welch, RM | 1 |
| Conney, AH | 1 |
| Burns, JJ | 1 |
| Stanulović, D | 1 |
| Vucković, S | 1 |
5 reviews available for phenacetin and Methemoglobinemia
| Article | Year |
|---|---|
[Pharmacogenetics of methemoglobin-producing agents].
Topics: Ascorbic Acid; Chlorates; Cytochrome-B(5) Reductase; Humans; Methemoglobin; Methemoglobinemia; Methy | 1980 |
Drug-induced oxidative haemolysis.
Topics: Absorption; Acute Kidney Injury; Disseminated Intravascular Coagulation; Disulfides; Erythrocyte Mem | 1980 |
[Genetically determined variations in drug response (author's transl)].
Topics: Acetyltransferases; Animals; Apnea; Butyrylcholinesterase; Cholinesterases; Genetic Variation; Gluco | 1975 |
Genetic determimants in drug action.
Topics: Acetylation; Acetyltransferases; Cholinesterases; Coumarins; Dealkylation; Drug Resistance; Genes; G | 1972 |
Pharmacogenetics.
Topics: Biotransformation; Cholinesterases; Coumarins; Genetic Variation; Genetics, Medical; Humans; Isoniaz | 1969 |
35 other studies available for phenacetin and Methemoglobinemia
| Article | Year |
|---|---|
Metabolic activation by human arylacetamide deacetylase, CYP2E1, and CYP1A2 causes phenacetin-induced methemoglobinemia.
Topics: Adult; Analgesics; Animals; Antipyretics; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitor | 2012 |
[Chronic methemoglobinemia consecutive to phenacetine poisoning].
Topics: Chronic Disease; Humans; Methemoglobinemia; Phenacetin | 1960 |
ANALGESIC NEPHROTOXICITY; A PHARMACOLOGICAL ANALYSIS.
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Antipyrine; Aspirin; Kidney Diseases; Methemoglo | 1964 |
[CLINICAL STUDIES ON CURRENT PROBLEMS OF PHENACETIN ADDICTION].
Topics: Anemia; Anemia, Hemolytic; Behavior, Addictive; Constipation; Cyanosis; Erythrocytes; Facial Express | 1964 |
[ACQUIRED METHEMOGLOBINEMIA IN THE INFANT. PRESENTATION OF A CASE].
Topics: Chloramphenicol; Dermatitis; Diarrhea; Diarrhea, Infantile; Drug Therapy; Humans; Infant; Infant, Ne | 1964 |
Introgenic collapse in sulphaemoglobinaemia. A case report.
Topics: Humans; Methemoglobinemia; Phenacetin; Shock; Surgical Procedures, Operative | 1962 |
Acquired methemoglobinemia due to ingestion of acetophenetidin. Report of a case in a small infant.
Topics: Child; Humans; Infant; Methemoglobinemia; Phenacetin | 1962 |
[Methemoglobinemia following administration of phenacetin and acet-4-chloranilide].
Topics: Humans; Methemoglobinemia; Phenacetin | 1950 |
[Abuse of phenacetin and methemoglobin formation].
Topics: Humans; Mental Disorders; Methemoglobin; Methemoglobinemia; Phenacetin; Substance-Related Disorders | 1952 |
Sulfhemoglobinemia: report of an unusual case.
Topics: Humans; Methemoglobinemia; Phenacetin; Sulfhemoglobinemia; Sulfuric Acids | 1962 |
Acetophenetidin sensitivity.
Topics: Adolescent; Adult; Anemia, Hemolytic; Female; Humans; Methemoglobinemia; Phenacetin; Phenobarbital | 1967 |
[Inhibition of the phenacetin and p-phenetidin induced methemoglobin picture by barbiturates].
Topics: Aniline Compounds; Animals; Barbiturates; Methemoglobinemia; Phenacetin; Rats | 1967 |
[A case of an antalgic-induced (Phenacetin + Acetanilid) sulf and methemoglobinemia in a woman receiving an antimetabolite (Methotrexate) (author's transl)].
Topics: Acetanilides; Female; Humans; Methemoglobin; Methemoglobinemia; Methotrexate; Middle Aged; Phenaceti | 1981 |
Drugs, genes and methemoglobinemia.
Topics: Cyanosis; Cytochrome-B(5) Reductase; Gene Frequency; Humans; Methemoglobinemia; Phenacetin | 1977 |
Phenacetin-induced sulfhemoglobinemia: report of a case and review of the literature.
Topics: Adult; Diagnosis, Differential; Female; Humans; Methemoglobinemia; Phenacetin; Substance-Related Dis | 1976 |
Phenacetin and paracetamol.
Topics: Acetaminophen; Anemia, Hemolytic; Central Nervous System; Chemical Phenomena; Chemistry; Humans; Kid | 1976 |
Sulfhemoglobinemia and methemoglobinemia--uncommon causes of cyanosis.
Topics: Anesthesia, Endotracheal; Cyanosis; Esophageal Neoplasms; Esophagogastric Junction; Humans; Male; Me | 1975 |
[Oxidant-drug induced hemolytic anemia in dogs].
Topics: Aminopyrine; Anemia, Hemolytic; Animals; Bilirubin; Blood Cell Count; Blood Proteins; Dogs; Female; | 1975 |
Suppression of phenacetin-induced methemoglobinemia by diethyldithiocarbamate and carbon disulfide and its relation to phenacetin metabolism in mice.
Topics: Animals; Biotransformation; Carbon Disulfide; Dealkylation; Ditiocarb; Male; Methemoglobinemia; Mice | 1985 |
[Case of methemoglobulinemia due to phenacetin].
Topics: Humans; Infant, Newborn; Male; Methemoglobinemia; NAD; Oxidoreductases; Phenacetin; Spectrophotometr | 1970 |
[Intestinal tuberculosis and methemoglobinemia].
Topics: Adult; Humans; Intestinal Obstruction; Male; Methemoglobinemia; Pentobarbital; Phenacetin; Tuberculo | 1972 |
[Acute hemolytic anemia with methemoglobinemia due to phenacetin: a case].
Topics: Anemia, Hemolytic; Female; Humans; Methemoglobinemia; Middle Aged; Migraine Disorders; Phenacetin | 1973 |
Phenacetin-induced methemoglobinemia and renal failure.
Topics: Acute Kidney Injury; Anesthesia; Cyanosis; Female; Humans; Methemoglobinemia; Phenacetin; Ureteral O | 1974 |
Analgesic abuse, anemia and chronic renal disease.
Topics: Anemia, Hemolytic; Female; Humans; Methemoglobinemia; Middle Aged; Nephritis, Interstitial; Phenacet | 1967 |
[Drug-induced toxic metahemoglobinemia].
Topics: Acetanilides; Adult; Aged; Female; Humans; Male; Methemoglobinemia; Middle Aged; Nitrites; Phenaceti | 1972 |
General and renal toxicity of phenacetin, paracetamol and some anti-mitotic agents in the rat.
Topics: Acetaminophen; Anemia, Macrocytic; Anilides; Animals; Blood; Blood Glucose; Body Weight; Caffeine; D | 1972 |
Alterations in normal and G-6-PD deficient human erythrocytes of various ages after exposure to metabolites of hemolytic drugs.
Topics: Adult; Erythrocyte Aging; Erythrocytes; Glucosephosphate Dehydrogenase Deficiency; Glutathione; Hemo | 1971 |
Acetophenetidin-induced methemoglobinemia.
Topics: Adolescent; Adult; Chromatography, Paper; Electrophoresis; Erythrocytes; Female; Glucosephosphate De | 1968 |
Drug-induced hemolysis: biochemical considerations.
Topics: Acetanilides; Anemia, Hemolytic; Aspirin; Biotransformation; Erythrocytes; Glucosephosphate Dehydrog | 1970 |
[On a case of extreme drug abuse in a girl during puberty].
Topics: Adolescent; Female; Guilt; Humans; Lymphadenitis; Masturbation; Methemoglobinemia; Phenacetin; Psych | 1968 |
[Influence of pretreatment with phenobarbital on the methemoglobin-inducing activity of phenacetin].
Topics: Animals; Cats; Methemoglobinemia; Phenacetin; Phenobarbital | 1968 |
Inhibition of phenacetin- and acetanilide-induced methemoglobinemia in the rat by the carboxylesterase inhibitor bis-[p-nitrophenyl] phosphate.
Topics: Acetanilides; Animals; Esterases; Female; Liver; Methemoglobin; Methemoglobinemia; Nitrophenols; Phe | 1969 |
Acetophenetidin-induced methemoglobinemia and its relation to the excretion of diazotizable amines.
Topics: Adolescent; Adult; Amines; Female; Glucuronates; Humans; Hydroxides; Male; Methemoglobinemia; Middle | 1969 |
The metabolism of acetophenetidin and N-acetyl-p-aminophenol in the cat.
Topics: Acetaminophen; Animals; Cats; Chromatography; Dogs; Glucuronates; Liver; Male; Methemoglobinemia; Me | 1966 |
[Drug-induced methemoglobinemia and sulfhemoglobinemias].
Topics: Humans; Methemoglobinemia; Phenacetin; Sulfhemoglobinemia | 1966 |