Page last updated: 2024-11-02

phenacetin and Innate Inflammatory Response

phenacetin has been researched along with Innate Inflammatory Response in 8 studies

Saridon: contains phenacetin, caffeine, propyphenazone & pyrithyldione

Research Excerpts

ExcerptRelevanceReference
"Plasma concentrations and pharmacokinetics of phenacetin, a CYP1A2 substrate were determined in normal and experimentally induced inflamed rats by turpentine oil to know the role of inflammation on the pharmacokinetics of phenacetin and formation of its active metabolite (paracetamol) by CYP1A2 in wistar albino rats, weighing about 200-250 g that were randomly divided into two groups consisting six in each group."7.81Turpentine oil induced inflammation decreases absorption and increases distribution of phenacetin without altering its elimination process in rats. ( Anand Kumar, P; Prasad, VG; Rao, GS; Ravi Kumar, P; Vivek, Ch, 2015)
"Plasma concentrations and pharmacokinetics of phenacetin, a CYP1A2 substrate were determined in normal and experimentally induced inflamed rats by turpentine oil to know the role of inflammation on the pharmacokinetics of phenacetin and formation of its active metabolite (paracetamol) by CYP1A2 in wistar albino rats, weighing about 200-250 g that were randomly divided into two groups consisting six in each group."3.81Turpentine oil induced inflammation decreases absorption and increases distribution of phenacetin without altering its elimination process in rats. ( Anand Kumar, P; Prasad, VG; Rao, GS; Ravi Kumar, P; Vivek, Ch, 2015)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19906 (75.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Saunders, MJ1
Edwards, BS1
Zhu, J1
Sklar, LA1
Graves, SW1
Prasad, VG1
Vivek, Ch1
Anand Kumar, P1
Ravi Kumar, P1
Rao, GS1
WAGNER-JAUREGG, T1
JAHN, U1
BUECH, O1
WHITEHOUSE, MW1
Brune, K1
Glenn, EM1
Bowman, BJ1
Rohloff, NA1
MacDonald, WC1
Boyd, EM1
Hottenroth, SM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Prospective, Randomized, Double-blind Study Assessing the Efficacy of Intravenous (IV) Ibuprofen Versus IV Acetaminophen for the Treatment of Pain Following Orthopaedic Low Extremity Surgery[NCT03771755]62 participants (Actual)Interventional2017-07-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for phenacetin and Innate Inflammatory Response

ArticleYear
[Analgesics: pharmacologic properties as a basis for rational therapy].
    Schweizerische medizinische Wochenschrift, 1978, Apr-29, Volume: 108, Issue:17

    Topics: Acetylcholine; Aminopyrine; Analgesics; Animals; Aspirin; Central Nervous System; Dogs; Encephalitis

1978

Other Studies

7 other studies available for phenacetin and Innate Inflammatory Response

ArticleYear
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
    Current protocols in cytometry, 2010, Volume: Chapter 13

    Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr

2010
Turpentine oil induced inflammation decreases absorption and increases distribution of phenacetin without altering its elimination process in rats.
    European journal of drug metabolism and pharmacokinetics, 2015, Volume: 40, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biotransformation; Chromatography, High Pressure L

2015
[The antiphlogistic testing of known antirheumatics on kaolin-induced rat paw edema].
    Arzneimittel-Forschung, 1962, Volume: 12

    Topics: Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Animals; Antipyretics; Antipyrine; Azoles; Edema;

1962
A BIOCHEMICAL DISTINCTION BETWEEN NON-STEROID ANTI-INFLAMMATORY AND ANALGESIC DRUGS.
    The Journal of pharmacy and pharmacology, 1963, Volume: 15

    Topics: Acetaminophen; Acetanilides; Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Ag

1963
Anti-inflammatory and PG inhibitory effects of phenacetin and acetaminophen.
    Agents and actions, 1977, Volume: 7, Issue:5-6

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Aspirin; Blood Platelets; Carrageenan; Cyclooxygen

1977
Correlation of mucosal histology and aspirin intake in chronic gastric ulcer.
    Gastroenterology, 1973, Volume: 65, Issue:3

    Topics: Adult; Aged; Aspirin; Caffeine; Chronic Disease; Epithelium; Female; Gastric Mucosa; Gastritis; Huma

1973
The toxicity of phenacetin at the range of the oral LD50(100 days) in albino rats.
    Toxicology and applied pharmacology, 1968, Volume: 12, Issue:1

    Topics: Animals; Asthenia; Ataxia; Caffeine; Chemical and Drug Induced Liver Injury; Cyanosis; Dehydration;

1968