phenacetin has been researched along with Disease Models, Animal in 10 studies
Saridon: contains phenacetin, caffeine, propyphenazone & pyrithyldione
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In order to discover and develop drug-like anti-inflammatory agents against arthritis, based on "Hit" we found earlier and to overcome drawbacks of toxicity, twelve series of total 89 novel pyrimidine, pyrazolo[4,3-d]pyrimidine and thieno[3,2-d]pyrimidine derivatives were designed, synthesized and screened for their anti-inflammatory activity against NO and toxicity for normal liver cells (LO2)." | 8.02 | Discovery and development of novel pyrimidine and pyrazolo/thieno-fused pyrimidine derivatives as potent and orally active inducible nitric oxide synthase dimerization inhibitor with efficacy for arthritis. ( Chen, LZ; Huang, X; Liu, MM; Liu, XH; Ma, D; Shi, JB; Shu, HY; Wu, J; Yu, YL, 2021) |
| "Plasma concentrations and pharmacokinetics of phenacetin, a CYP1A2 substrate were determined in normal and experimentally induced inflamed rats by turpentine oil to know the role of inflammation on the pharmacokinetics of phenacetin and formation of its active metabolite (paracetamol) by CYP1A2 in wistar albino rats, weighing about 200-250 g that were randomly divided into two groups consisting six in each group." | 7.81 | Turpentine oil induced inflammation decreases absorption and increases distribution of phenacetin without altering its elimination process in rats. ( Anand Kumar, P; Prasad, VG; Rao, GS; Ravi Kumar, P; Vivek, Ch, 2015) |
| "We have investigated the effect of malaria infection with the rodent parasite Plasmodium berghei and fever induced by Escherichia coli endotoxin on the metabolism of phenacetin to paracetamol by rat liver microsomes from young (4 weeks old) male Wistar rats (N = 5 in control and fever groups; N = 10 in malaria-infected group)." | 7.68 | Effect of malaria infection and endotoxin-induced fever on phenacetin O-deethylation by rat liver microsomes. ( Breckenridge, AM; Edwards, G; Glazier, AP; Kokwaro, GO; Ward, SA, 1993) |
| "In order to discover and develop drug-like anti-inflammatory agents against arthritis, based on "Hit" we found earlier and to overcome drawbacks of toxicity, twelve series of total 89 novel pyrimidine, pyrazolo[4,3-d]pyrimidine and thieno[3,2-d]pyrimidine derivatives were designed, synthesized and screened for their anti-inflammatory activity against NO and toxicity for normal liver cells (LO2)." | 4.02 | Discovery and development of novel pyrimidine and pyrazolo/thieno-fused pyrimidine derivatives as potent and orally active inducible nitric oxide synthase dimerization inhibitor with efficacy for arthritis. ( Chen, LZ; Huang, X; Liu, MM; Liu, XH; Ma, D; Shi, JB; Shu, HY; Wu, J; Yu, YL, 2021) |
| "Plasma concentrations and pharmacokinetics of phenacetin, a CYP1A2 substrate were determined in normal and experimentally induced inflamed rats by turpentine oil to know the role of inflammation on the pharmacokinetics of phenacetin and formation of its active metabolite (paracetamol) by CYP1A2 in wistar albino rats, weighing about 200-250 g that were randomly divided into two groups consisting six in each group." | 3.81 | Turpentine oil induced inflammation decreases absorption and increases distribution of phenacetin without altering its elimination process in rats. ( Anand Kumar, P; Prasad, VG; Rao, GS; Ravi Kumar, P; Vivek, Ch, 2015) |
| "We have investigated the effect of malaria infection with the rodent parasite Plasmodium berghei and fever induced by Escherichia coli endotoxin on the metabolism of phenacetin to paracetamol by rat liver microsomes from young (4 weeks old) male Wistar rats (N = 5 in control and fever groups; N = 10 in malaria-infected group)." | 3.68 | Effect of malaria infection and endotoxin-induced fever on phenacetin O-deethylation by rat liver microsomes. ( Breckenridge, AM; Edwards, G; Glazier, AP; Kokwaro, GO; Ward, SA, 1993) |
| "Phenacetin metabolism was impaired more severely in 6 rats that died than in 21 living rats (P < 0." | 1.38 | Phenacetin O-deethylation is a useful tool for evaluation of hepatic functional reserve in rats with CCl(4)-induced chronic liver injury. ( Cai, M; He, P; Li, X; Liu, Z; Qu, Z; Wang, X; Xiao, J; Zhou, M, 2012) |
| " We previously applied a toxicogenomic approach to the toxicity by analyzing microarray data of the liver of rats dosed with two hemolytic agents: phenylhydrazine and phenacetin." | 1.34 | Toxicogenomics of drug-induced hemolytic anemia by analyzing gene expression profiles in the spleen. ( Araki, A; Furukawa, N; Imura, K; Ishizaki, J; Itoh, F; Kato, I; Miyazaki, M; Okada, M; Omi, K; Rokushima, M; Torii, M; Yamamoto, J, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 3 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xue, ST | 1 |
| Zhang, L | 1 |
| Xie, ZS | 1 |
| Jin, J | 1 |
| Guo, HF | 1 |
| Yi, H | 1 |
| Liu, ZY | 1 |
| Li, ZR | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Chen, LZ | 1 |
| Shu, HY | 1 |
| Wu, J | 1 |
| Yu, YL | 1 |
| Ma, D | 1 |
| Huang, X | 1 |
| Liu, MM | 1 |
| Liu, XH | 1 |
| Shi, JB | 1 |
| Prasad, VG | 1 |
| Vivek, Ch | 1 |
| Anand Kumar, P | 1 |
| Ravi Kumar, P | 1 |
| Rao, GS | 1 |
| Liu, Z | 1 |
| Qu, Z | 1 |
| Li, X | 1 |
| Cai, M | 1 |
| He, P | 1 |
| Zhou, M | 1 |
| Xiao, J | 1 |
| Wang, X | 1 |
| Zhang, Y | 1 |
| Jia, Y | 1 |
| Yang, M | 1 |
| Yang, P | 1 |
| Tian, Y | 1 |
| Xiao, A | 1 |
| Wen, A | 1 |
| Cruz-Antonio, L | 1 |
| Flores-Murrieta, FJ | 1 |
| García-Löpez, P | 1 |
| Guízar-Sahagún, G | 1 |
| Castañeda-Hernández, G | 1 |
| Rokushima, M | 2 |
| Omi, K | 1 |
| Imura, K | 1 |
| Araki, A | 1 |
| Furukawa, N | 1 |
| Itoh, F | 1 |
| Miyazaki, M | 1 |
| Yamamoto, J | 1 |
| Okada, M | 1 |
| Torii, M | 1 |
| Kato, I | 1 |
| Ishizaki, J | 1 |
| Cohen, SM | 1 |
| Greenfield, RE | 1 |
| Friedell, GH | 1 |
| Kokwaro, GO | 1 |
| Glazier, AP | 1 |
| Ward, SA | 1 |
| Breckenridge, AM | 1 |
| Edwards, G | 1 |
1 review available for phenacetin and Disease Models, Animal
| Article | Year |
|---|---|
Urinary bladder carcinogenesis.
Topics: Amines; Aniline Compounds; Animals; Carcinogens; Carcinoma; Carcinoma, Squamous Cell; Disease Models | 1982 |
9 other studies available for phenacetin and Disease Models, Animal
| Article | Year |
|---|---|
Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic Protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model, and ADME properties.
Topics: Animals; Benzofurans; Bone Morphogenetic Protein 2; Caco-2 Cells; Disease Models, Animal; Dose-Respo | 2020 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Discovery and development of novel pyrimidine and pyrazolo/thieno-fused pyrimidine derivatives as potent and orally active inducible nitric oxide synthase dimerization inhibitor with efficacy for arthritis.
Topics: Administration, Oral; Animals; Arthritis; Cells, Cultured; Dimerization; Disease Models, Animal; Dos | 2021 |
Turpentine oil induced inflammation decreases absorption and increases distribution of phenacetin without altering its elimination process in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biotransformation; Chromatography, High Pressure L | 2015 |
Phenacetin O-deethylation is a useful tool for evaluation of hepatic functional reserve in rats with CCl(4)-induced chronic liver injury.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chronic Disease; | 2012 |
The impaired disposition of probe drugs is due to both liver and kidney dysfunctions in CCl(4)-model rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Arylsulfotransferase; Carbon Tetrachloride Poisoni | 2012 |
Understanding drug disposition alterations induced by acute spinal cord injury: role of injury level and route of administration for agents submitted to extensive liver metabolism.
Topics: Acetaminophen; Administration, Oral; Animals; Denervation; Disease Models, Animal; Female; Hepatic A | 2006 |
Toxicogenomics of drug-induced hemolytic anemia by analyzing gene expression profiles in the spleen.
Topics: Anemia, Hemolytic; Animals; Biomarkers, Pharmacological; Cluster Analysis; Disease Models, Animal; F | 2007 |
Effect of malaria infection and endotoxin-induced fever on phenacetin O-deethylation by rat liver microsomes.
Topics: Acetaminophen; Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Disease Models, Ani | 1993 |