phenacetin has been researched along with Chemical and Drug Induced Liver Injury in 35 studies
Saridon: contains phenacetin, caffeine, propyphenazone & pyrithyldione
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "10 Phenylbutazone may cause liver injury and other analgesics can cause hypersensitivity reactions in which the liver is involved." | 2.36 | Hepatotoxicity of mild analgesics. ( Prescott, LF, 1980) |
| "Phenacetin metabolism was impaired more severely in 6 rats that died than in 21 living rats (P < 0." | 1.38 | Phenacetin O-deethylation is a useful tool for evaluation of hepatic functional reserve in rats with CCl(4)-induced chronic liver injury. ( Cai, M; He, P; Li, X; Liu, Z; Qu, Z; Wang, X; Xiao, J; Zhou, M, 2012) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "Acetaminophen (APAP) is safe at therapeutic levels but causes liver injury via N-acetyl-p-benzoquinone imine (NAPQI)-induced oxidative stress when overdose." | 1.35 | Prevention of acetaminophen (APAP)-induced hepatotoxicity by leflunomide via inhibition of APAP biotransformation to N-acetyl-p-benzoquinone imine. ( Chan, EC; New, LS; Tan, SC, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (60.00) | 18.7374 |
| 1990's | 1 (2.86) | 18.2507 |
| 2000's | 3 (8.57) | 29.6817 |
| 2010's | 9 (25.71) | 24.3611 |
| 2020's | 1 (2.86) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Liu, Z | 3 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Abe, M | 1 |
| Kumagi, T | 1 |
| Nakanishi, S | 1 |
| Yamagami, T | 1 |
| Michitaka, K | 1 |
| Abe, K | 1 |
| Okura, I | 1 |
| Yamashita, H | 1 |
| Horiike, N | 1 |
| Onji, M | 1 |
| Mizogami, M | 1 |
| Tsuchiya, H | 1 |
| Lin, K | 1 |
| Zhang, Q | 1 |
| Yang, S | 1 |
| Lin, Y | 1 |
| Wen, C | 1 |
| Zheng, Y | 1 |
| Tan, SC | 1 |
| New, LS | 1 |
| Chan, EC | 1 |
| Qu, Z | 1 |
| Li, X | 1 |
| Cai, M | 1 |
| He, P | 1 |
| Zhou, M | 1 |
| Xiao, J | 1 |
| Wang, X | 1 |
| Zhang, Y | 1 |
| Jia, Y | 1 |
| Yang, M | 1 |
| Yang, P | 1 |
| Tian, Y | 1 |
| Xiao, A | 1 |
| Wen, A | 1 |
| EDER, H | 1 |
| Zhang, L | 1 |
| Mu, X | 1 |
| Fu, J | 1 |
| Zhou, Z | 1 |
| de Vries, J | 1 |
| Hanks, GW | 1 |
| Baker, AL | 1 |
| Kotake, AN | 1 |
| Schoeller, DA | 1 |
| Prescott, LF | 2 |
| Nagasaki, Y | 1 |
| Kawasaki, Y | 1 |
| Nishi, S | 1 |
| Yamamoto, H | 1 |
| Shioji, N | 1 |
| Yamamoto, Y | 1 |
| Nishioka, S | 1 |
| Yataka, I | 1 |
| Ikeda, Y | 1 |
| Shima, Y | 1 |
| Miyamoto, C | 1 |
| Tanaka, T | 1 |
| Offerhaus, L | 1 |
| Fischer, W | 1 |
| Scheuer, PJ | 1 |
| Mitchell, JR | 2 |
| Potter, WZ | 1 |
| Kapetanović, IM | 1 |
| Mieyal, JJ | 1 |
| Nelson, SD | 2 |
| Forte, AJ | 1 |
| McMurtry, RJ | 2 |
| Thorgeirsson, SS | 1 |
| Dybing, E | 1 |
| Siegers, CP | 1 |
| Strubelt, O | 1 |
| Schütt, A | 1 |
| Cuthbert, MF | 1 |
| Murray, RM | 1 |
| Klinge, O | 1 |
| Altmann, HW | 1 |
| Berneis, K | 1 |
| Studer, A | 1 |
| Boyd, EM | 2 |
| Hottenroth, SM | 1 |
| Bereczky, GM | 1 |
7 reviews available for phenacetin and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Nonprescription analgesics.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug Induced Liver Inj | 1983 |
Clinical utility of breath tests for the assessment of hepatic function.
Topics: Aminopyrine; Breath Tests; Caffeine; Chemical and Drug Induced Liver Injury; Chronic Disease; Cytoch | 1983 |
Hepatotoxicity of mild analgesics.
Topics: Acetaminophen; Adult; Analgesics; Aspirin; Chemical and Drug Induced Liver Injury; Child; Humans; Ph | 1980 |
Long-term effects on the liver.
Topics: Anabolic Agents; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Cholestasis; Chr | 1975 |
Drug metabolism in the production of liver injury.
Topics: Acetaminophen; Acetanilides; Alkylating Agents; Bromobenzenes; Chemical and Drug Induced Liver Injur | 1975 |
The third Lilly Prize Lecture. University of London, January, 1979. The nephrotoxicity and hepatotoxicity of antipyretic analgesics.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug Induced Liver Inj | 1979 |
Metabolic activation: biochemical basis for many drug-induced liver injuries.
Topics: Acetaminophen; Animals; Binding Sites; Carcinogens; Chemical and Drug Induced Liver Injury; Drug Hyp | 1976 |
28 other studies available for phenacetin and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Drug-induced hepatitis with hepatic granuloma due to saridon.
Topics: Adult; Antipyrine; Biopsy, Needle; Caffeine; Chemical and Drug Induced Liver Injury; Dose-Response R | 2002 |
Acetaminophen Has Lipid Composition-Dependent Membrane Interactivity That Could Be Related to Nephrotoxicity but Not to Analgesic Activity and Hepatotoxicity.
Topics: Acetaminophen; Analgesics; Chemical and Drug Induced Liver Injury; Humans; Phenacetin; Phospholipids | 2022 |
Effects of suberoylanilide hydroxamic acid on rat cytochrome P450 enzyme activities.
Topics: Administration, Oral; Animals; Bupropion; Chemical and Drug Induced Liver Injury; Chromatography, Li | 2015 |
Prevention of acetaminophen (APAP)-induced hepatotoxicity by leflunomide via inhibition of APAP biotransformation to N-acetyl-p-benzoquinone imine.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antirheumatic Agents; Benzoquinones; Biotransforma | 2008 |
Phenacetin O-deethylation is a useful tool for evaluation of hepatic functional reserve in rats with CCl(4)-induced chronic liver injury.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chronic Disease; | 2012 |
The impaired disposition of probe drugs is due to both liver and kidney dysfunctions in CCl(4)-model rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Arylsulfotransferase; Carbon Tetrachloride Poisoni | 2012 |
CHRONIC TOXICITY STUDIES ON PHENACETIN, N-ACETYL-P-AMINOPHENOL (NAPA) AND ACETYLSALICYLIC ACID ON CATS.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Aspirin; Cats; Chemical and Drug | 1964 |
In vitro cytotoxicity assay with selected chemicals using human cells to predict target-organ toxicity of liver and kidney.
Topics: Acetaminophen; Aristolochic Acids; Cadmium Chloride; Cell Line; Cell Survival; Chemical and Drug Ind | 2007 |
Hepatotoxic metabolic activation of paracetamol and its derivatives phenacetin and benorilate: oxygenation or electron transfer?
Topics: Acetaminophen; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Electron Transpor | 1981 |
[A case of black liver induced by phenacetin abuse (author's transl)].
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Diseases; Phenacetin; Su | 1981 |
[Phenacetin or paracetamol?].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Drug Prescriptions; Humans; Kidney Papillary | 1980 |
[H. U. Zollinger: 25 years of phenacetin abuse].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Kidney Diseases; Legislation, Drug; P | 1980 |
Inhibition of acetaminophen-induced hepatotoxicity by phenacetin and its alkoxy analogs.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Isocitrate Dehydrogenas | 1979 |
Decreased toxicity of the N-methyl analogs of acetaminophen and phenacetin.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cricetinae; Male; Mesocricetus; Meth | 1978 |
[Antipyretic analgesics derived from para-aminophenol].
Topics: Acetaminophen; Aminophenols; Chemical and Drug Induced Liver Injury; Kidney; Phenacetin | 1990 |
Proceedings: Hepatotoxicity and metabolism of paracetamol in rats and mice.
Topics: Acetaminophen; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Chromatography | 1974 |
Adverse reactions to non-steroidal antirheumatic drugs.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Benzophenones; Chemical and Drug Induced Liv | 1974 |
Dependance on analgesics in analgesic nephropathy.
Topics: Adult; Aged; Analgesics; Aspirin; Caffeine; Chemical and Drug Induced Liver Injury; Codeine; Female; | 1973 |
[Morphology of toxic hepatoses].
Topics: Alcoholism; Chemical and Drug Induced Liver Injury; Cholestasis; Diagnosis, Differential; Endoplasmi | 1971 |
[Comparative studies on lipofuscin of various origin from human and animal liver].
Topics: Animals; Centrifugation, Density Gradient; Chemical and Drug Induced Liver Injury; Dogs; Female; Hum | 1968 |
The toxicity of phenacetin at the range of the oral LD50(100 days) in albino rats.
Topics: Animals; Asthenia; Ataxia; Caffeine; Chemical and Drug Induced Liver Injury; Cyanosis; Dehydration; | 1968 |
Liver necrosis from paracetamol.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Male; Necrosis; Organ Size; Phenacet | 1966 |