phaclofen has been researched along with Seizures in 7 studies
phaclofen: peripheral & central baclofen & GABA antagonist; structure given in first source
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Effects of the GABA(B) receptor agonist ((+/-)-baclofen), antagonist (phaclofen), and their combination were tested against clonic seizures induced by cocaine (75 mg/kg)." | 7.72 | Pharmacological modulation of GABA(B) receptors affects cocaine-induced seizures in mice. ( Gasior, M; Kaminski, R; Witkin, JM, 2004) |
| "Effects of the GABA(B) receptor agonist ((+/-)-baclofen), antagonist (phaclofen), and their combination were tested against clonic seizures induced by cocaine (75 mg/kg)." | 3.72 | Pharmacological modulation of GABA(B) receptors affects cocaine-induced seizures in mice. ( Gasior, M; Kaminski, R; Witkin, JM, 2004) |
| "Our findings indicated that PTZ-induced seizure showed not only decrease in GABABR expression but also cause neuronal apoptosis in the developing rat brain." | 1.39 | Decreased GABABR expression and increased neuronal cell death in developing rat brain after PTZ-induced seizure. ( Al-Qahtani, MH; Ansari, SA; Bibi, F; Karim, S; Kim, MO; Naseer, MI; Ullah, I; Ullah, N, 2013) |
| "P(2)X(7) receptor immunoreactivity in seizure-resistant (SR) gerbils was similar to that in pre-seizure group of seizure-sensitive (SS) gerbils." | 1.32 | GABA(B) receptor-mediated regulation of P2X7 receptor expression in the gerbil hippocampus. ( An, SJ; Hwang, IK; Kang, TC; Park, SK; Won, MH, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Naseer, MI | 1 |
| Ullah, I | 1 |
| Al-Qahtani, MH | 1 |
| Karim, S | 1 |
| Ullah, N | 1 |
| Ansari, SA | 1 |
| Kim, MO | 1 |
| Bibi, F | 1 |
| Kang, TC | 2 |
| Park, SK | 1 |
| Hwang, IK | 1 |
| An, SJ | 1 |
| Won, MH | 2 |
| Gasior, M | 1 |
| Kaminski, R | 1 |
| Witkin, JM | 1 |
| Kwak, SE | 1 |
| Kim, JE | 1 |
| Kim, DS | 1 |
| Jung, JY | 1 |
| Kwon, OS | 1 |
| Choi, SY | 1 |
| Humeniuk, RE | 1 |
| White, JM | 1 |
| Ong, J | 1 |
| Snead, OC | 1 |
| Mehta, AK | 1 |
| Ticku, MK | 1 |
7 other studies available for phaclofen and Seizures
| Article | Year |
|---|---|
Decreased GABABR expression and increased neuronal cell death in developing rat brain after PTZ-induced seizure.
Topics: Animals; Animals, Newborn; Baclofen; Caspase 3; Cell Death; Disease Models, Animal; Electroencephalo | 2013 |
GABA(B) receptor-mediated regulation of P2X7 receptor expression in the gerbil hippocampus.
Topics: Analysis of Variance; Animals; Baclofen; Bicuculline; Cell Count; GABA Agonists; GABA Antagonists; G | 2004 |
Pharmacological modulation of GABA(B) receptors affects cocaine-induced seizures in mice.
Topics: Animals; Baclofen; Cocaine; Dopamine Uptake Inhibitors; GABA-A Receptor Agonists; GABA-A Receptor An | 2004 |
Effects of GABAergic transmissions on the immunoreactivities of calcium binding proteins in the gerbil hippocampus.
Topics: Animals; Baclofen; Bicuculline; Calbindin 2; Calbindins; Calcium-Binding Proteins; Cell Count; GABA | 2005 |
The effects of GABAB ligands on alcohol withdrawal in mice.
Topics: Animals; Baclofen; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Ethanol; Female; GA | 1994 |
Relation of the [3H] gamma-hydroxybutyric acid (GHB) binding site to the gamma-aminobutyric acidB (GABAB) receptor in rat brain.
Topics: Animals; Autoradiography; Baclofen; Benzocycloheptenes; Binding Sites; Brain; GABA Agonists; GABA An | 1996 |
Are GABAB receptors involved in the pharmacological effects of ethanol?
Topics: Animals; Baclofen; Cells, Cultured; Chlorine; Diazepam; Ethanol; gamma-Aminobutyric Acid; Male; Mice | 1990 |