phaclofen has been researched along with Rett Syndrome in 1 studies
phaclofen: peripheral & central baclofen & GABA antagonist; structure given in first source
Rett Syndrome: An inherited neurological developmental disorder that is associated with X-LINKED INHERITANCE and may be lethal in utero to hemizygous males. The affected female is normal until the age of 6-25 months when progressive loss of voluntary control of hand movements and communication skills; ATAXIA; SEIZURES; autistic behavior; intermittent HYPERVENTILATION; and HYPERAMMONEMIA appear. (From Menkes, Textbook of Child Neurology, 5th ed, p199)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rett syndrome is an autism spectrum disorder resulting from defects in the gene encoding the methyl-CpG-binding protein 2 (MeCP2)." | 1.39 | GABAergic synaptic inputs of locus coeruleus neurons in wild-type and Mecp2-null mice. ( Cui, N; Jiang, C; Jin, X; Jin, XT; Zhong, W, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jin, X | 1 |
| Cui, N | 1 |
| Zhong, W | 1 |
| Jin, XT | 1 |
| Jiang, C | 1 |
1 other study available for phaclofen and Rett Syndrome
| Article | Year |
|---|---|
GABAergic synaptic inputs of locus coeruleus neurons in wild-type and Mecp2-null mice.
Topics: Animals; Baclofen; Female; GABA Antagonists; GABA-A Receptor Agonists; GABA-B Receptor Agonists; GAB | 2013 |