Page last updated: 2024-10-21

phaclofen and Obesity

phaclofen has been researched along with Obesity in 1 studies

phaclofen: peripheral & central baclofen & GABA antagonist; structure given in first source

Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).

Research Excerpts

ExcerptRelevanceReference
" Minute ventilation (Ve), tidal volume (Vt), and breathing frequency (f) during room air breathing and in response to 10 min of hypercapnia (8% CO(2)) and 30 min of hypoxia (10% O(2)) were measured by the barometric method, and peak oxygen consumption (Vo(2 peak)) was measured by an enclosed metabolic treadmill following the randomized blinded subcutaneous administration of equal volumes of DMSO (vehicle), bicuculline (selective GABA(A) receptor antagonist, 1 mg/kg), and phaclofen (selective GABA(B) receptor antagonist, 1 mg/kg)."3.74GABA(A) and GABA(B) receptors differentially modulate volume and frequency in ventilatory compensation in obese Zucker rats. ( Chen, JS; Huang, CY; Lee, SD; Lo, MJ; Ting, H; Yang, AL, 2007)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yang, AL1
Lo, MJ1
Ting, H1
Chen, JS1
Huang, CY1
Lee, SD1

Other Studies

1 other study available for phaclofen and Obesity

ArticleYear
GABA(A) and GABA(B) receptors differentially modulate volume and frequency in ventilatory compensation in obese Zucker rats.
    Journal of applied physiology (Bethesda, Md. : 1985), 2007, Volume: 102, Issue:1

    Topics: Animals; Baclofen; Bicuculline; Dimethyl Sulfoxide; GABA Antagonists; Hypercapnia; Hypoxia; Male; Ob

2007