phaclofen has been researched along with Anesthesia in 5 studies
phaclofen: peripheral & central baclofen & GABA antagonist; structure given in first source
Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Muscimol was without effect in pylorus-ligated rats, whereas baclofen produced a significant decrease in acid secretion, which was fully prevented by phaclofen." | 1.28 | Central GABAA excitatory and GABAB inhibitory receptors regulate gastric acid secretion in rats. ( Bernardini, MC; Blandizzi, C; Del Tacca, M, 1990) |
| "Pretreatment with bicuculline, a GABAA-receptor antagonist, in the doses of 1 and 3 mg/kg, subcutaneously, had no influence on the gastric acid response to baclofen." | 1.28 | Effects of GABA antagonists and structural GABA analogues on baclofen stimulated gastric acid secretion in the rat. ( Goto, Y; Hara, N; Hara, Y, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blandizzi, C | 2 |
| Colucci, R | 1 |
| Carignani, D | 1 |
| Natale, G | 1 |
| Lazzeri, G | 1 |
| Crema, F | 1 |
| Del Tacca, M | 2 |
| Bernardini, MC | 1 |
| Kaneko, T | 1 |
| Hicks, TP | 1 |
| Hara, N | 1 |
| Hara, Y | 1 |
| Goto, Y | 1 |
5 other studies available for phaclofen and Anesthesia
| Article | Year |
|---|---|
Role of peripheral GABAB receptors in the regulation of pepsinogen secretion in anaesthetized rats.
Topics: Anesthesia; Animals; Baclofen; Capsaicin; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; | 1995 |
Potentiation by baclofen of gastric acid secretion stimulated by secretagogues in vagotomized rats under anesthesia.
Topics: Anesthesia; Animals; Baclofen; Bethanechol Compounds; Body Temperature; Dose-Response Relationship, | 1996 |
Central GABAA excitatory and GABAB inhibitory receptors regulate gastric acid secretion in rats.
Topics: Anesthesia; Animals; Baclofen; Bicuculline; Central Nervous System; Dose-Response Relationship, Drug | 1990 |
GABA(B)-related activity involved in synaptic processing of somatosensory information in S1 cortex of the anaesthetized cat.
Topics: Anesthesia; Animals; Baclofen; Bicuculline; Cats; Electric Stimulation; Electrodes; Female; gamma-Am | 1990 |
Effects of GABA antagonists and structural GABA analogues on baclofen stimulated gastric acid secretion in the rat.
Topics: Amino Acids; Anesthesia; Animals; Baclofen; Bethanechol Compounds; Bicuculline; GABA Antagonists; ga | 1990 |