pf-877423 has been researched along with Cognitive-Dysfunction* in 1 studies
1 other study(ies) available for pf-877423 and Cognitive-Dysfunction
| Article | Year |
|---|---|
Design, synthesis and in vivo study of novel pyrrolidine-based 11β-HSD1 inhibitors for age-related cognitive dysfunction.
Recent findings suggest that treatment with 11β-HSD1 inhibitors provides a novel approach to deal with age-related cognitive dysfunctions, including Alzheimer's disease. In this work we report potent 11β-HSD1 inhibitors featuring unexplored pyrrolidine-based polycyclic substituents. A selected candidate administered to 12-month-old SAMP8 mice for four weeks prevented memory deficits and displayed a neuroprotective action. This is the first time that 11β-HSD1 inhibitors have been studied in this broadly-used mouse model of accelerated senescence and late-onset Alzheimer's disease. Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Age Factors; Animals; Cognitive Dysfunction; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; HEK293 Cells; Humans; Male; Mice; Microsomes, Liver; Models, Molecular; Molecular Structure; Pyrrolidines; Structure-Activity Relationship | 2017 |