Page last updated: 2024-11-03

pf 5901 and Pancreatic Neoplasms

pf 5901 has been researched along with Pancreatic Neoplasms in 3 studies

alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol: structure given in first source; platelet activating factor antagonist

Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).

Research Excerpts

ExcerptRelevanceReference
"Pancreatic cancer has an abysmal prognosis because of late diagnosis."1.335-Lipoxygenase, a marker for early pancreatic intraepithelial neoplastic lesions. ( Adrian, TE; Bell, RH; Buchler, MW; Ding, XZ; Friess, H; Grippo, P; Hennig, R; Rao, SM; Talamonti, MS, 2005)
"Apoptosis of pancreatic cancer cells induced by LOX inhibitors (including the nonselective LOX inhibitor nordihydroguaiaretic acid, the 5-LOX inhibitor Rev-5901, and the 12-LOX inhibitor baicalein) was confirmed by growth inhibition, annexin V binding, and terminal deoxynucleotidyl transferase-mediated nick end labeling assay in MiaPaCa-2 and AsPC-1 human pancreatic cancer cells."1.31Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway. ( Adrian, TE; Ding, XZ; Tong, WG; Witt, RC, 2002)
"Four human pancreatic cancer cell lines, PANC-1, MiaPaca2, Capan2, and HPAF, were used."1.30Lipoxygenase inhibition induced apoptosis, morphological changes, and carbonic anhydrase expression in human pancreatic cancer cells. ( Adrian, TE; Ding, XZ; El-Metwally, TH; Kuszynski, CA, 1999)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's2 (66.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tong, WG1
Ding, XZ3
Witt, RC1
Adrian, TE3
Hennig, R1
Grippo, P1
Rao, SM1
Buchler, MW1
Friess, H1
Talamonti, MS1
Bell, RH1
Kuszynski, CA1
El-Metwally, TH1

Other Studies

3 other studies available for pf 5901 and Pancreatic Neoplasms

ArticleYear
Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway.
    Molecular cancer therapeutics, 2002, Volume: 1, Issue:11

    Topics: Animals; Annexin A5; Apoptosis; Arachidonate 12-Lipoxygenase; Arachidonate 5-Lipoxygenase; Arachidon

2002
5-Lipoxygenase, a marker for early pancreatic intraepithelial neoplastic lesions.
    Cancer research, 2005, Jul-15, Volume: 65, Issue:14

    Topics: Adenocarcinoma; Animals; Arachidonate 5-Lipoxygenase; Biomarkers, Tumor; Carcinogens; Carcinoma in S

2005
Lipoxygenase inhibition induced apoptosis, morphological changes, and carbonic anhydrase expression in human pancreatic cancer cells.
    Biochemical and biophysical research communications, 1999, Dec-20, Volume: 266, Issue:2

    Topics: Apoptosis; Carbonic Anhydrases; Cell Differentiation; Cell Division; Cell Size; DNA Fragmentation; F

1999