pf 5901 has been researched along with Pancreatic Neoplasms in 3 studies
alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol: structure given in first source; platelet activating factor antagonist
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pancreatic cancer has an abysmal prognosis because of late diagnosis." | 1.33 | 5-Lipoxygenase, a marker for early pancreatic intraepithelial neoplastic lesions. ( Adrian, TE; Bell, RH; Buchler, MW; Ding, XZ; Friess, H; Grippo, P; Hennig, R; Rao, SM; Talamonti, MS, 2005) |
| "Apoptosis of pancreatic cancer cells induced by LOX inhibitors (including the nonselective LOX inhibitor nordihydroguaiaretic acid, the 5-LOX inhibitor Rev-5901, and the 12-LOX inhibitor baicalein) was confirmed by growth inhibition, annexin V binding, and terminal deoxynucleotidyl transferase-mediated nick end labeling assay in MiaPaCa-2 and AsPC-1 human pancreatic cancer cells." | 1.31 | Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway. ( Adrian, TE; Ding, XZ; Tong, WG; Witt, RC, 2002) |
| "Four human pancreatic cancer cell lines, PANC-1, MiaPaca2, Capan2, and HPAF, were used." | 1.30 | Lipoxygenase inhibition induced apoptosis, morphological changes, and carbonic anhydrase expression in human pancreatic cancer cells. ( Adrian, TE; Ding, XZ; El-Metwally, TH; Kuszynski, CA, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tong, WG | 1 |
| Ding, XZ | 3 |
| Witt, RC | 1 |
| Adrian, TE | 3 |
| Hennig, R | 1 |
| Grippo, P | 1 |
| Rao, SM | 1 |
| Buchler, MW | 1 |
| Friess, H | 1 |
| Talamonti, MS | 1 |
| Bell, RH | 1 |
| Kuszynski, CA | 1 |
| El-Metwally, TH | 1 |
3 other studies available for pf 5901 and Pancreatic Neoplasms
| Article | Year |
|---|---|
Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway.
Topics: Animals; Annexin A5; Apoptosis; Arachidonate 12-Lipoxygenase; Arachidonate 5-Lipoxygenase; Arachidon | 2002 |
5-Lipoxygenase, a marker for early pancreatic intraepithelial neoplastic lesions.
Topics: Adenocarcinoma; Animals; Arachidonate 5-Lipoxygenase; Biomarkers, Tumor; Carcinogens; Carcinoma in S | 2005 |
Lipoxygenase inhibition induced apoptosis, morphological changes, and carbonic anhydrase expression in human pancreatic cancer cells.
Topics: Apoptosis; Carbonic Anhydrases; Cell Differentiation; Cell Division; Cell Size; DNA Fragmentation; F | 1999 |