pf-562-271 and Neoplasms

pf-562-271 has been researched along with Neoplasms* in 2 studies

Reviews

1 review(s) available for pf-562-271 and Neoplasms

ArticleYear
Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view.
    European journal of medicinal chemistry, 2017, Jul-07, Volume: 134

    Indoles constitute extensively explored heterocyclic ring systems with wide range of applications in pathophysiological conditions that is, cancer, microbial and viral infections, inflammation, depression, migraine, emesis, hypertension, etc. Presence of indole nucleus in amino acid tryptophan makes it prominent in phytoconstituents such as perfumes, neurotransmitters, auxins (plant hormones), indole alkaloids etc. The interesting molecular architecture of indole makes them suitable candidates for the drug development. This review article provides an overview of the chemistry, biology, and toxicology of indoles focusing on their application as drugs. Our effort is to corroborate the information available on the natural indole alkaloids, indole based FDA approved drugs and clinical trial candidates having diverse therapeutic implementations. This compiled information may serve as a benchmark for the alteration of existing ligands to design novel potent molecules with lesser side effects.

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Antiemetics; Antineoplastic Agents; Bacterial Infections; Chemistry, Pharmaceutical; Cholinergic Antagonists; Drug Discovery; Humans; Indoles; Migraine Disorders; Mycoses; Neoplasms; Virus Diseases

2017

Other Studies

1 other study(ies) available for pf-562-271 and Neoplasms

ArticleYear
Identification of Thieno[3,2-
    Journal of medicinal chemistry, 2021, 08-26, Volume: 64, Issue:16

    Focal adhesion kinase (FAK) is overexpressed in highly invasive and metastatic cancers. To identify novel FAK inhibitors, we designed and synthesized various thieno[3,2-

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; fms-Like Tyrosine Kinase 3; Focal Adhesion Kinase 1; Humans; Mice, Inbred BALB C; Mice, Nude; Molecular Docking Simulation; Molecular Structure; Neoplasm Metastasis; Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Pyrimidines; Structure-Activity Relationship; Thiophenes; Xenograft Model Antitumor Assays

2021