pf-3758309 and Colorectal-Neoplasms

pf-3758309 has been researched along with Colorectal-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for pf-3758309 and Colorectal-Neoplasms

ArticleYear
Depletion of p21-activated kinase 1 up-regulates the immune system of APC
    BMC cancer, 2017, Jun-19, Volume: 17, Issue:1

    P21-activated kinase 1 (PAK1) stimulates growth and metastasis of colorectal cancer (CRC) through activation of multiple signalling pathways. Up-regulation of CRC stem cell markers by PAK1 also contributes to the resistance of CRC to 5-fluorouracil. The aim of this study was to investigate the effect of PAK1 depletion and inhibition on the immune system and on intestinal tumour formation in APC. The PAK1 KO APC. Compared to APC. Depletion of active PAK1 up-regulates the immune system of APC

    Topics: Animals; Biomarkers; Cell Line, Tumor; Cell Transformation, Neoplastic; Colorectal Neoplasms; Disease Models, Animal; Genes, APC; Genotype; Immune System; Immunohistochemistry; Immunomodulation; Leukocyte Count; Lymphocytes; Mice; Mice, Knockout; Neutrophils; p21-Activated Kinases; Polycomb Repressive Complex 1; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Pyrazoles; Pyrroles

2017