pf-04620110 and Diabetes-Mellitus

pf-04620110 has been researched along with Diabetes-Mellitus* in 1 studies

Other Studies

1 other study(ies) available for pf-04620110 and Diabetes-Mellitus

Article	Year
Synthesis and biological evaluation of aminobenzimidazole derivatives with a phenylcyclohexyl acetic acid group as anti-obesity and anti-diabetic agents. Bioorganic & medicinal chemistry letters, 2013, Aug-15, Volume: 23, Issue:16 A series of benzimidazole derivatives with a phenylcyclohexyl acetic acid group as DGAT-1 inhibitors was developed. Among the benzimidazole series, compound 5k showed submicromolar in vitro activity toward human and mouse DGAT-1, good selectivity toward DGAT-2, human liver metabolic stability, and pharmacokinetic (PK) and safety profiles such as hERG, CYP and acute toxicity. Additionally, 5k showed good in vivo efficacy in 4weeks study with DIO mouse model. Topics: Acetic Acid; Animals; Anti-Obesity Agents; Benzimidazoles; Cells, Cultured; Cyclization; Diabetes Mellitus; Disease Models, Animal; Humans; Hypoglycemic Agents; Liver; Mice; Molecular Structure; Obesity	2013

Article

Year

Synthesis and biological evaluation of aminobenzimidazole derivatives with a phenylcyclohexyl acetic acid group as anti-obesity and anti-diabetic agents.

Bioorganic & medicinal chemistry letters, 2013, Aug-15, Volume: 23, Issue:16

A series of benzimidazole derivatives with a phenylcyclohexyl acetic acid group as DGAT-1 inhibitors was developed. Among the benzimidazole series, compound 5k showed submicromolar in vitro activity toward human and mouse DGAT-1, good selectivity toward DGAT-2, human liver metabolic stability, and pharmacokinetic (PK) and safety profiles such as hERG, CYP and acute toxicity. Additionally, 5k showed good in vivo efficacy in 4weeks study with DIO mouse model.

Topics: Acetic Acid; Animals; Anti-Obesity Agents; Benzimidazoles; Cells, Cultured; Cyclization; Diabetes Mellitus; Disease Models, Animal; Humans; Hypoglycemic Agents; Liver; Mice; Molecular Structure; Obesity

2013