pf-04620110 and Diabetes-Mellitus--Type-2

pf-04620110 has been researched along with Diabetes-Mellitus--Type-2* in 1 studies

Other Studies

1 other study(ies) available for pf-04620110 and Diabetes-Mellitus--Type-2

Article	Year
Model-based pharmacokinetic and pharmacodynamic analysis for acute effects of a small molecule inhibitor of diacylglycerol acyltransferase-1 in the TallyHo/JngJ polygenic mouse. Xenobiotica; the fate of foreign compounds in biological systems, 2019, Volume: 49, Issue:7 The purpose of this study was to evaluate the acute effect of a small molecule inhibitor of DGAT-1 on triglycerides (TG) and cholesterol in polygenic type 2 diabetic TallyHo/JngJ (TH) mice. PF-04620110, a potent and selective DGAT-1 inhibitor, was used as a model compound in this study and which was administered to TH and ICR mice. The concentration of the model compound that produced 50% of maximum lowering of TG level (IC Topics: Animals; Cholesterol; Diabetes Mellitus, Type 2; Diacylglycerol O-Acyltransferase; Mice; Mice, Inbred ICR; Mice, Transgenic; Models, Biological; Oxazepines; Triglycerides	2019

Article

Year

Model-based pharmacokinetic and pharmacodynamic analysis for acute effects of a small molecule inhibitor of diacylglycerol acyltransferase-1 in the TallyHo/JngJ polygenic mouse.

Xenobiotica; the fate of foreign compounds in biological systems, 2019, Volume: 49, Issue:7

The purpose of this study was to evaluate the acute effect of a small molecule inhibitor of DGAT-1 on triglycerides (TG) and cholesterol in polygenic type 2 diabetic TallyHo/JngJ (TH) mice. PF-04620110, a potent and selective DGAT-1 inhibitor, was used as a model compound in this study and which was administered to TH and ICR mice. The concentration of the model compound that produced 50% of maximum lowering of TG level (IC

Topics: Animals; Cholesterol; Diabetes Mellitus, Type 2; Diacylglycerol O-Acyltransferase; Mice; Mice, Inbred ICR; Mice, Transgenic; Models, Biological; Oxazepines; Triglycerides

2019