pf-04418948 and Intracranial-Aneurysm

pf-04418948 has been researched along with Intracranial-Aneurysm* in 1 studies

Other Studies

1 other study(ies) available for pf-04418948 and Intracranial-Aneurysm

Article	Year
Prostaglandin E2-EP2-NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms. Science signaling, 2017, 02-07, Volume: 10, Issue:465 Intracranial aneurysms are common but are generally untreated, and their rupture can lead to subarachnoid hemorrhage. Because of the poor prognosis associated with subarachnoid hemorrhage, preventing the progression of intracranial aneurysms is critically important. Intracranial aneurysms are caused by chronic inflammation of the arterial wall due to macrophage infiltration triggered by monocyte chemoattractant protein-1 (MCP-1), macrophage activation mediated by the transcription factor nuclear factor κB (NF-κB), and inflammatory signaling involving prostaglandin E Topics: Animals; Azetidines; Blotting, Western; Chemokine CCL2; Cyclooxygenase 2; Dinoprostone; Gene Expression Profiling; HEK293 Cells; Humans; Intracranial Aneurysm; Macrophages; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microscopy, Confocal; NF-kappa B; NF-KappaB Inhibitor alpha; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E, EP2 Subtype; Signal Transduction; Tumor Necrosis Factor-alpha	2017

Article

Year

Prostaglandin E2-EP2-NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms.

Science signaling, 2017, 02-07, Volume: 10, Issue:465

Intracranial aneurysms are common but are generally untreated, and their rupture can lead to subarachnoid hemorrhage. Because of the poor prognosis associated with subarachnoid hemorrhage, preventing the progression of intracranial aneurysms is critically important. Intracranial aneurysms are caused by chronic inflammation of the arterial wall due to macrophage infiltration triggered by monocyte chemoattractant protein-1 (MCP-1), macrophage activation mediated by the transcription factor nuclear factor κB (NF-κB), and inflammatory signaling involving prostaglandin E

Topics: Animals; Azetidines; Blotting, Western; Chemokine CCL2; Cyclooxygenase 2; Dinoprostone; Gene Expression Profiling; HEK293 Cells; Humans; Intracranial Aneurysm; Macrophages; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microscopy, Confocal; NF-kappa B; NF-KappaB Inhibitor alpha; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E, EP2 Subtype; Signal Transduction; Tumor Necrosis Factor-alpha

2017