pexidartinib and Neurodegenerative-Diseases

Chronic activation of brain innate immunity is a prominent feature of Alzheimer's disease (AD) and primary tauopathies. However, to what degree innate immunity contributes to neurodegeneration as compared with pathological protein-induced neurotoxicity, and the requirement of a particular glial cell type in neurodegeneration, are still unclear. Here we demonstrate that microglia-mediated damage, rather than pathological tau-induced direct neurotoxicity, is the leading force driving neurodegeneration in a tauopathy mouse model. Importantly, the progression of ptau pathology is also driven by microglia. In addition, we found that

Topics: Alzheimer Disease; Aminopyridines; Animals; Apolipoproteins E; Brain; Dietary Supplements; Disease Models, Animal; Humans; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microglia; Neurodegenerative Diseases; Pyrroles; tau Proteins; Tauopathies