pexidartinib has been researched along with Cocaine-Related-Disorders* in 1 studies
1 other study(ies) available for pexidartinib and Cocaine-Related-Disorders
| Article | Year |
|---|---|
Inhibition of CSF1R, a receptor involved in microglia viability, alters behavioral and molecular changes induced by cocaine.
Different data suggest that microglia may participate in the drug addiction process as these cells respond to neurochemical changes induced by the administration of these substances. In order to study the role of microglia in drug abuse, Swiss mice aged 8-9 weeks were treated with the CSF1R inhibitor PLX3397 (40 mg/kg, p.o.) and submitted to behavioral sensitization or conditioned place preference (CPP) induced by cocaine (15 mg/kg, i.p.). Thereafter, brains were used to evaluate the effects of CSF1R inhibition and cocaine administration on morphological, biochemical and molecular changes. CSF1R inhibition attenuated behavioral sensitization, reduced the number of Iba-1 Topics: Aminopyridines; Animals; Behavior, Animal; Brain; Chemokine CX3CL1; Cocaine; Cocaine-Related Disorders; Conditioning, Classical; Dopamine Uptake Inhibitors; Hippocampus; Inhibition, Psychological; Male; Mice; Microglia; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor | 2021 |