pevonedistat and Liver-Cirrhosis

pevonedistat has been researched along with Liver-Cirrhosis* in 1 studies

Other Studies

1 other study(ies) available for pevonedistat and Liver-Cirrhosis

Article	Year
Deregulated neddylation in liver fibrosis. Hepatology (Baltimore, Md.), 2017, Volume: 65, Issue:2 Hepatic fibrosis is a global health problem currently without effective therapeutic approaches. Even though the ubiquitin-like posttranslational modification of neddylation, that conjugates Nedd8 (neural precursor cell expressed developmentally downregulated) to specific targets, is aberrant in many pathologies, its relevance in liver fibrosis (LF) remained unexplored. Our results show deregulated neddylation in clinical fibrosis and both in mouse bileductligation- and CCl. Neddylation inhibition reduces fibrosis, suggesting neddylation as a potential and attractive therapeutic target in liver fibrosis. (Hepatology 2017;65:694-709). Topics: Aging; Analysis of Variance; Animals; Apoptosis; Biopsy, Needle; Cell Proliferation; Cell Survival; Cells, Cultured; Chemokine CCL4; Chemokines; Cyclopentanes; Disease Models, Animal; Hepatic Stellate Cells; Humans; Immunohistochemistry; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; NEDD8 Protein; Pyrimidines; Random Allocation; Signal Transduction; Ubiquitins	2017

Article

Year

Deregulated neddylation in liver fibrosis.

Hepatology (Baltimore, Md.), 2017, Volume: 65, Issue:2

Hepatic fibrosis is a global health problem currently without effective therapeutic approaches. Even though the ubiquitin-like posttranslational modification of neddylation, that conjugates Nedd8 (neural precursor cell expressed developmentally downregulated) to specific targets, is aberrant in many pathologies, its relevance in liver fibrosis (LF) remained unexplored. Our results show deregulated neddylation in clinical fibrosis and both in mouse bileductligation- and CCl. Neddylation inhibition reduces fibrosis, suggesting neddylation as a potential and attractive therapeutic target in liver fibrosis. (Hepatology 2017;65:694-709).

Topics: Aging; Analysis of Variance; Animals; Apoptosis; Biopsy, Needle; Cell Proliferation; Cell Survival; Cells, Cultured; Chemokine CCL4; Chemokines; Cyclopentanes; Disease Models, Animal; Hepatic Stellate Cells; Humans; Immunohistochemistry; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; NEDD8 Protein; Pyrimidines; Random Allocation; Signal Transduction; Ubiquitins

2017