pevonedistat and Fish-Diseases

Neddylation is a type of post-translational protein modifications, in which neural precursor cell expressed developmentally downregulated protein 8 (NEDD8) is covalently conjugated to the lysine residues of target substrates. The best characterized principal substrates of neddylation are the cullin-RING ligases (CRLs). In addition, neddylation also modifies non-cullin proteins to affect gene regulation, cell survival, organ development, and stress response. However, the role of neddylation in antiviral innate immunity remain largely unknown. Here, we found that when neddylation was blocked by the NEDD8 activating enzyme E1 (NAE) inhibitor, MLN4924, the cellular and organismal antiviral response was suppressed. Moreover, the disruption of

Topics: Animals; Cell Line; Cyclopentanes; Fish Diseases; NEDD8 Protein; Pyrimidines; Rhabdoviridae; Rhabdoviridae Infections; Signal Transduction; Ubiquitination; Zebrafish; Zebrafish Proteins