pervanadate has been researched along with Pulmonary-Fibrosis* in 1 studies
1 other study(ies) available for pervanadate and Pulmonary-Fibrosis
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Interstitial lung disease in polymyositis and dermatomyositis.
To assess prevalence, characteristics, and long-term outcome of interstitial lung disease (ILD) in polymyositis (PM) and dermatomyositis (DM). To determine predictive variables of ILD course in PM/DM, and to define both clinical and biochemical features associated with ILD onset in PM/DM.. The medical records of 156 consecutive PM/DM patients in 3 medical centers were reviewed.. Thirty-six PM/DM patients (23.1%) developed ILD. We observed that 19.4% of patients with ILD had resolution of pulmonary disorders, whereas 25% experienced ILD deterioration. Morbidity and mortality rates were as high as 13.9% and 36.4%, respectively, in PM/DM patients with ILD. Parameters of PM/DM that related to ILD poor outcome were identified as follows: Hamman-Rich-like pattern, initial diffusing capacity of carbon monoxide <45%, neutrophil alveolitis, and histologic usual interstitial pneumonia. Additionally, for the group with ILD, polyarthritis, higher values of erythrocyte sedimentation rate and C-reactive protein, presence of anti-Jo-1 antibody, and characteristic microangiopathy were significantly more frequent.. Our series underlines the high frequency of ILD in PM/DM patients, resulting in increased morbidity and mortality rates. It also indicates that PM/DM patients should routinely be screened for ILD, even those patients without anti-Jo-1 antibody, because 69% of our ILD patients were seronegative for the anti-Jo-1 antibody. Our findings further suggest that PM/DM patients presenting with factors predictive of ILD poor outcome may require more aggressive therapy. Topics: Antibodies, Antinuclear; Biopsy; Blood Sedimentation; C-Reactive Protein; Dermatomyositis; Female; Humans; Lung Diseases, Interstitial; Male; Middle Aged; Polymyositis; Predictive Value of Tests; Pulmonary Fibrosis; Retrospective Studies; Risk Factors; Survival Analysis; Vanadates | 2002 |