pervanadate and Adrenal-Cortex-Neoplasms

Cyclic AMP induces corticosteroid production, differential gene transcription, and cell cycle arrest in adrenal cortex-derived Y1 cells. These responses follow a cAMP-controlled transformation in Y1 cell morphology: the conversion of flat epithelial cells into rounded, highly refractile cells with short processes. Little is known about effector proteins and mechanisms that link activated protein kinase A to the alteration in cell shape. We now report that cAMP causes rapid (

Topics: Actins; Adrenal Cortex Neoplasms; Animals; Cell Adhesion Molecules; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytoskeletal Proteins; Cytoskeleton; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Isoflavones; Mice; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Tyrosine; Vanadates