Page last updated: 2024-11-02

perphenazine and Weight Gain

perphenazine has been researched along with Weight Gain in 8 studies

Perphenazine: An antipsychotic phenothiazine derivative with actions and uses similar to those of CHLORPROMAZINE.
perphenazine : A phenothiazine derivative in which the phenothiazine tricycle carries a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at N-10.

Weight Gain: Increase in BODY WEIGHT over existing weight.

Research Excerpts

ExcerptRelevanceReference
" Further, fewer preclinical adverse events were noted with 17m compared with risperidone in assays that measured prolactin secretion and weight gain."3.79Synthesis and biological investigation of coumarin piperazine (piperidine) derivatives as potential multireceptor atypical antipsychotics. ( Chen, Y; Liu, BF; Liu, S; Liu, X; Qiu, Y; Wang, S; Xu, X; Yu, M; Zhang, G; Zhang, T; Zhao, S, 2013)
" An association between weight gain, obstructive sleep apnea, and lithium treatment is also illustrated."3.68Four cases of obstructive sleep apnea associated with treatment-resistant mania. ( Alpert, JE; Frankenburg, FR; Hudson, JI; Keck, PE; Strakowski, SM; Teschke, GC; Tohen, M; Wilson, DR, 1991)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's3 (37.50)29.6817
2010's4 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kroeze, WK1
Hufeisen, SJ1
Popadak, BA1
Renock, SM1
Steinberg, S1
Ernsberger, P1
Jayathilake, K1
Meltzer, HY1
Roth, BL1
Chen, Y1
Wang, S1
Xu, X1
Liu, X1
Yu, M1
Zhao, S1
Liu, S1
Qiu, Y1
Zhang, T1
Liu, BF1
Zhang, G1
Bellavia, A1
Centorrino, F1
Jackson, JW1
Fitzmaurice, G1
Valeri, L1
Ramsey, TL1
Brennan, MD1
Robinson, LA1
Penzner, JB1
Arkow, S1
Kahn, DA1
Berman, JA1
Lieberman, JA1
Stroup, TS1
McEvoy, JP1
Swartz, MS1
Rosenheck, RA1
Perkins, DO1
Keefe, RS1
Davis, SM1
Davis, CE1
Lebowitz, BD1
Severe, J1
Hsiao, JK1
Strassnig, M1
Miewald, J1
Keshavan, M1
Ganguli, R1
Strakowski, SM1
Hudson, JI1
Keck, PE1
Wilson, DR1
Frankenburg, FR1
Alpert, JE1
Teschke, GC1
Tohen, M1

Clinical Trials (10)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Orally-Disintegrating vs. Regular Olanzapine Tablets: Effects on Weight and GI Hormones[NCT00384332]Phase 420 participants (Actual)Interventional2007-01-31Completed
Relative Effectiveness of Schizophrenia Therapy (REST) Study[NCT01245348]1,110 participants (Actual)Observational2010-12-31Completed
Comparative Effectiveness of Antipsychotic Medications in Patients With Schizophrenia (CATIE Schizophrenia Trial)[NCT00014001]Phase 41,600 participants Interventional2000-12-31Completed
Feasibility of Using Holographic Memory Resolution® (HMR) in Patients/Clients With Pain[NCT05001399]60 participants (Actual)Interventional2021-10-25Completed
Clinical Utility of Pharmacogenomics of Psychotropic Medications[NCT03907124]Phase 40 participants (Actual)Interventional2019-06-03Withdrawn (stopped due to PI left institution prior to recruitment.)
A Phase IIA, Prospective, Randomized, Double-blind, Multiple-dose Study of NW-3509A in Chronic Schizoprhenia Patients Not Responding to Their Current Anti-psychotic Medication[NCT02624167]Phase 290 participants (Actual)Interventional2015-12-31Completed
1/2-MC4R Genotype and Pediatric Antipsychotic Drug- Induced Weight Gain[NCT01844700]Phase 414 participants (Actual)Interventional2013-07-31Terminated (stopped due to very slow recruitment, no sufficient results)
Pharmacologic Augmentation of Neurocognition and Cognitive Training in Psychosis[NCT02634684]Phase 282 participants (Actual)Interventional2014-07-01Completed
Reducing Cardiovascular Risk in Adults With Serious Mental Illness Using an Electronic Medical Record-based Clinical Decision Support[NCT02451670]10,347 participants (Actual)Interventional2016-01-20Completed
A Randomized, Double-Blind, Active-Controlled, Multicenter Study to Evaluate Efficacy and Safety Study of Iloperidone Virus Risperidone to Treat Schizophrenia[NCT01623713]Phase 2260 participants (Actual)Interventional2012-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change From Baseline Montgomery Asberg Depression Rating Scale

Montgomery Asberg Depression Rating Scale (MADRS) total score. Construct: Depression severity. Scores below represent mean change scores, endpoint minus baseline. Minimum total score: 0 (no depression). Maximum total score: 60 (severe depression). Lower (more negative) scores indicate a better outcome. There are no subscales. (NCT00384332)
Timeframe: 10 weeks

Interventionunits on a scale (Mean)
Arm 1-15.5
Arm 2-15.5

Weight in Kilograms at Baseline, Weeks 1, 4, 6, and 8

Change in weight from baseline to endpoint in kilograms. Reported as weight in Kilograms at Baseline, Weeks 1, 4, 6, and 8 (NCT00384332)
Timeframe: 10 weeks

,
Interventionkilograms (Mean)
BaselineWeek 1Week 4Week 6Week 8
Arm 1- ODT76.077.477.878.979.1
Arm 2- SOT76.177.678.379.480.1

Percent Weight Change Compared to Baseline Weight

(NCT01844700)
Timeframe: baseline to week 12

Interventionpercentage of weight change (Mean)
Ziprasidone11.58
Aripiprazole, Quetiapine, Risperidone5.66

BMI Percentile

(NCT01844700)
Timeframe: baseline to week 12

,
InterventionBMI percentile (Mean)
baselineweek 12 (n=1, n=2)
Aripiprazole, Quetiapine, Risperidone37.6762.5
Ziprasidone3259

BMI Z-scores

(NCT01844700)
Timeframe: baseline to week 12

,
InterventionBMI z-score (Mean)
baselineweek 12 (n=1, n=2)
Aripiprazole, Quetiapine, Risperidone-0.370.38
Ziprasidone-0.510.22

Weight Change

(NCT01844700)
Timeframe: baseline to week 12

,
Interventionlbs (Mean)
baselineweek 12 (n=1,2)
Aripiprazole, Quetiapine, Risperidone118.5141
Ziprasidone120.5151

MATRICS Consensus Cognitive Battery Performance (MCCB)

The T-score indicates the performance on a neurocognitive battery of tests. Higher score reflects better performance. (NCT02634684)
Timeframe: two visits, 1 week apart, each visit lasting approximately 6 hours

,,,
Interventionstandardized T-score (Mean)
placeboamphetamine
Healthy Subjects: 10 mg Amphetamine 1st, Then Placebo57.87056.000
Healthy Subjects: Placebo 1st, Then 10 mg Amphetamine54.47655.476
Subjects With Schizophrenia: 10 mg Amphetamine 1st, Then Placebo39.89538.105
Subjects With Schizophrenia: Placebo 1st, Then 10 mg Amphetamine31.89533.842

Prepulse Inhibition (PPI)

"PPI was assessed with 42 trials of 6 types: 118 dB 40 ms pulse alone (P) & the same P preceded 10, 20, 30, 60, or 120 ms by a prepulse (pp) 16 dB over background. Startle magnitude (SM), habituation, latency & latency facilitation were measured to interpret changes in PPI.~%PPI = 100 x [(SM on P trials) - (SM on pp+P trials)] / SM on P trials. Example:~SM on P trials = 80 units SM on pp+P trials = 30 units %PPI = 100 x (80-30)/80 = 100 x 50/80 = 62.5%~Greater %PPI mean the reflex has been inhibited to a greater extent in the presence of a pp.~%PPI can't exceed 100: when SM on pp+P trials = 0, then %PPI = 100 x (SM on P trials - 0)/SM on P trials = 100 x 1 = 100%.~However, %PPI can theoretically be infinitely negative since SM on pp+P trials could be infinitely large (prepulse facilitiation (PPF)), i.e. SM is potentiated in the presence of a pp. PPF is normal at very short & very long pp intervals, but not within a species-specific physiological range of intervals." (NCT02634684)
Timeframe: two visits, 1 week apart, each visit lasting approximately 6 hours

,,,
Intervention% inhibition of startle (Mean)
PlaceboAmphetamine
Healthy Subjects: 10 mg Amphetamine 1st, Then Placebo50.62653.029
Healthy Subjects: Placebo 1st, Then 10 mg Amphetamine50.62645.822
Subjects With Schizophrenia: 10 mg Amphetamine 1st, Then Placebo41.16239.545
Subjects With Schizophrenia: Placebo 1st, Then 10 mg Amphetamine22.62932.656

Targeted Cognitive Training (TCT): PositScience, Inc.

"Auditory discrimination learning: Subjects identify direction (up vs. down) of 2 consecutive sound sweeps. Parameters (e.g. inter-sweep interval, sweep duration) are established for subjects to maintain 80% correct responses. On screen and test days, subjects complete 1h of TCT. Analytic software yields the key measures: auditory processing speed (APS) and APS learning. APS is the shortest inter-stimulus interval at which a subject performs to criteria and APS learning is the difference (ms) between the first APS and the best APS of the subsequent trials. A smaller APS reflects better discrimination (i.e., subject correctly identified frequency sweep direction despite a smaller ms gap between stimuli) and a larger ms value for APS learning reflects more learning, i.e., faster APS with repeated trials. Limits for APS are capped at 0-to-1000 ms; values for APS learning are capped at (-) 1000-to-APS." (NCT02634684)
Timeframe: two visits, 1 week apart, each visit lasting approximately 6 hours

,,,
Interventionmsec (Mean)
placeboamphetamine
Healthy Subjects: 10 mg Amphetamine 1st, Then Placebo-2.11329.190
Healthy Subjects: Placebo 1st, Then 10 mg Amphetamine5.91135.905
Subjects With Schizophrenia: 10 mg Amphetamine 1st, Then Placebo-50.158101.000
Subjects With Schizophrenia: Placebo 1st, Then 10 mg Amphetamine-15.11852.647

Predicted Annual Rate of Change in 10 Year Risk of Fatal or Nonfatal Heart Attack or Stroke

A modifiable risk component for each cardiovascular risk factor not at optimal goal at the time of each encounter was calculated as the difference between total 10-year atherosclerotic cardiovascular disease risk with the patient's actual values and the goal value. Total modifiable cardiovascular risk was calculated by summing the modifiable cardiovascula risk components across cardiovascular risk factors not at optimal goal at the time of the encounter, and was calculated for each enrolled patient at the index visit and each subsequent encounter during the intervention period. Annual rate of change in modifiable cardiovascular risk was estimated from all patient encounters. A comparison of the difference in model-estimated rate of change in modifiable cardiovascular risk at 12 months post-index tested the primary efficacy hypothesis. (NCT02451670)
Timeframe: Index to 12 months post index visit

Interventionpercentage of annual rate of change (Number)
Prioritized Clinical Decision Support14.2
Usual Care20.8

Trials

3 trials available for perphenazine and Weight Gain

ArticleYear
The role of weight gain in explaining the effects of antipsychotic drugs on positive and negative symptoms: An analysis of the CATIE schizophrenia trial.
    Schizophrenia research, 2019, Volume: 206

    Topics: Adult; Antipsychotic Agents; Body-Weight Trajectory; Female; Humans; Male; Middle Aged; Olanzapine;

2019
Glucagon-like peptide 1 receptor (GLP1R) haplotypes correlate with altered response to multiple antipsychotics in the CATIE trial.
    Schizophrenia research, 2014, Volume: 160, Issue:1-3

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Biomarkers, Pharmacological; Dibenzothiazepines; Femal

2014
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
    The New England journal of medicine, 2005, Sep-22, Volume: 353, Issue:12

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Dibenzothiazepines; Double-Blind Meth

2005

Other Studies

5 other studies available for perphenazine and Weight Gain

ArticleYear
H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:3

    Topics: Animals; Antipsychotic Agents; Discriminant Analysis; Drug Evaluation, Preclinical; Forecasting; Hum

2003
Synthesis and biological investigation of coumarin piperazine (piperidine) derivatives as potential multireceptor atypical antipsychotics.
    Journal of medicinal chemistry, 2013, Jun-13, Volume: 56, Issue:11

    Topics: Animals; Antipsychotic Agents; Avoidance Learning; Biological Availability; Coumarins; ERG1 Potassiu

2013
Electroconvulsive therapy for the treatment of refractory mania.
    Journal of psychiatric practice, 2011, Volume: 17, Issue:1

    Topics: Antipsychotic Agents; Bipolar Disorder; Electroconvulsive Therapy; Female; Follow-Up Studies; Humans

2011
Weight gain in newly diagnosed first-episode psychosis patients and healthy comparisons: one-year analysis.
    Schizophrenia research, 2007, Volume: 93, Issue:1-3

    Topics: Adult; Affective Disorders, Psychotic; Antipsychotic Agents; Benzodiazepines; Body Mass Index; Dose-

2007
Four cases of obstructive sleep apnea associated with treatment-resistant mania.
    The Journal of clinical psychiatry, 1991, Volume: 52, Issue:4

    Topics: Adult; Bipolar Disorder; Clonazepam; Female; Follow-Up Studies; Hospitalization; Humans; Lithium; Mi

1991