perphenazine and Vomiting studies

Perphenazine: An antipsychotic phenothiazine derivative with actions and uses similar to those of CHLORPROMAZINE.
perphenazine : A phenothiazine derivative in which the phenothiazine tricycle carries a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at N-10.

Vomiting: The forcible expulsion of the contents of the STOMACH through the MOUTH.

Research Excerpts

Excerpt	Relevance	Reference
"The effects of dexamethasone and perphenazine on vomiting after tonsillectomy in children were compared in 226 healthy children aged 2-12 yr."	9.08	Prophylaxis for vomiting by children after tonsillectomy: dexamethasone versus perphenazine. ( Roberts, DJ; Splinter, W, 1997)
"To test the hypothesis that perphenazine decreases the incidence of vomiting by children after tonsillectomy."	9.08	Perphenazine decreases vomiting by children after tonsillectomy. ( Roberts, DJ; Splinter, WM, 1997)
"We have compared the effects of ondansetron and perphenazine on vomiting after tonsillectomy in 216 healthy children, aged 2-12 yr."	9.08	Prophylaxis for vomiting by children after tonsillectomy: ondansetron compared with perphenazine. ( Rhine, EJ; Splinter, WM, 1998)
"Metoclopramide was ineffective."	6.68	The efficacy of prophylactic ondansetron, droperidol, perphenazine, and metoclopramide in the prevention of nausea and vomiting after major gynecologic surgery. ( Clark, K; Cronin, MK; Darvish, AH; Desilva, PH; McDonald, SM, 1995)
"The effects of dexamethasone and perphenazine on vomiting after tonsillectomy in children were compared in 226 healthy children aged 2-12 yr."	5.08	Prophylaxis for vomiting by children after tonsillectomy: dexamethasone versus perphenazine. ( Roberts, DJ; Splinter, W, 1997)
"To compare the efficacy of two antiemetic regimens, ondansetron alone versus perphenazine with diphenhydramine, on emesis control in children undergoing conditioning therapy for bone marrow transplantation (BMT)."	5.08	Controlling conditioning-related emesis in children undergoing bone marrow transplantation. ( Kuhlman, C; Mehta, NH; Parsons, SK; Reed, CM; Weinstein, HJ, 1997)
"To test the hypothesis that perphenazine decreases the incidence of vomiting by children after tonsillectomy."	5.08	Perphenazine decreases vomiting by children after tonsillectomy. ( Roberts, DJ; Splinter, WM, 1997)
"We have compared the effects of ondansetron and perphenazine on vomiting after tonsillectomy in 216 healthy children, aged 2-12 yr."	5.08	Prophylaxis for vomiting by children after tonsillectomy: ondansetron compared with perphenazine. ( Rhine, EJ; Splinter, WM, 1998)
"To compare the prophylactic administration of ondansetron plus droperidol, droperidol plus metoclopramide, and perphenazine to determine effects on postoperative nausea, vomiting, and sedation after laparoscopic cholecystectomy."	5.08	Prophylactic antiemetics for laparoscopic cholecystectomy: a comparison of perphenazine, droperidol plus ondansetron, and droperidol plus metoclopramide. ( Freiberger, D; Gosnell, JL; Steinbrook, RA, 1998)
"Metoclopramide was ineffective."	2.68	The efficacy of prophylactic ondansetron, droperidol, perphenazine, and metoclopramide in the prevention of nausea and vomiting after major gynecologic surgery. ( Clark, K; Cronin, MK; Darvish, AH; Desilva, PH; McDonald, SM, 1995)

Research

Studies (50)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Average Amount of Meal Per Day

Average Frequency of Meals Per Day

Timeframe	Studies, this research(%)	All Research%
pre-1990	44 (88.00)	18.7374
1990's	6 (12.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
WEISS, S	1
WEISS, J	1
WEISS, B	1
ERNST, EM	1
SNYDER, AM	1
PREISIG, R	1
LANDMAN, ME	1
SCURR, CF	1
ROBBIE, DS	1
HOMBURGER, F	1
WANG, SC	2
RADAELLI, C	1
BIRNBERG, CH	1
SCHWARTZ, AA	1
WIENER, S	1
MONTGOMERY, RD	1
SUTHERLAND, VL	1
ANDERSON, G	1
ALBERT, C	1
HENLEY, E	1
WITTEN, S	1
WINSHEL, A	1
ALBERT, S	1
STEWART, BL	1
GRAHAM, GK	1
CONGER, CW	1
CLAASSEN, LG	1
HAMELBERG, W	1
LANDEEN, FH	1
LIND, B	3
BAIN, RM	1
CUTOLO, LC	1
KLEPPEL, NH	1
D'AGOSTINO, A	1
BONVINO, G	1
GRAN, L	1
PURKIS, IE	2
ISHII, M	1
PASQUIER, J	1
TISSOT, A	1
WEAVER, LC	1
RAHDERT, E	1
RICHARDS, AB	1
ABREU, BE	1
GORDEICHEVA, NV	1
BJERKELUND, C	1
NITTER-HAUGE, S	1
JAKOBSEN, E	1
MANN, D	1
EL-SHIRBINY, A	1
ROBERTS, H	1
Desilva, PH	1
Darvish, AH	1
McDonald, SM	1
Cronin, MK	1
Clark, K	1
Splinter, W	1
Roberts, DJ	2
Mehta, NH	1
Reed, CM	1
Kuhlman, C	1
Weinstein, HJ	1
Parsons, SK	1
Splinter, WM	2
Rhine, EJ	1
Steinbrook, RA	1
Gosnell, JL	1
Freiberger, D	1
Gralla, EJ	1
Sabo, JP	1
Hayden, DW	1
Yochmowitz, MG	1
Mattsson, JL	1
Chestnutt, WN	1
Dundee, JW	1
Roland, P	1
Grimeland, J	1
Bellman, MH	1
Frigerio, G	1
Handley, AJ	1
Breivik, H	1
McGarry, JM	1
Papp, RH	1
Hawkins, HB	1
Share, NN	1
Larrauri, RM	1
Barron, CN	1
Murchison, TE	1
Rubin, LF	1
Rubin, ML	1
Herron, W	1
Muscarella, M	1
Birkhead, H	1
Schorscher, E	1
Sommer, S	1
Wild, AJ	1
Rizzi, R	1
Cecconello, D	1
Bissanti, A	1
Bradshaw, RB	1
Morpurgo, C	1
Theobald, W	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Effect of Steroids on Post-tonsillectomy Morbidities[NCT02401529]	Phase 2	100 participants (Actual)	Interventional	2013-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	participants (Number)
	inadequate	adequate
IV Dexamethasone and Oral Prednisolone	16	34
Placebo	27	23

average frequency of meals (1 meal, 2 meals, if more specify) (NCT02401529)
Timeframe: average number of meals consumed per day for the 1st three days post-surgery

Duration of Post-operative Nausea

Intervention	participants (Number)
	1 meal	2 meals	3 meals
IV Dexamethasone and Oral Prednisolone	2	20	28
Placebo	1	34	15

Postoperative nausea duration (no nausea,1 day, 2 days, 3 days, 4 days, if more specify) (NCT02401529)
Timeframe: 7 days

Duration of Post-operative Pain

Intervention	participants (Number)
	no nausea	one day	two days	three days
IV Dexamethasone and Oral Prednisolone	33	3	14	0
Placebo	21	8	15	6

4 selections (1 day, 2 days, 3 days, if more specify) (NCT02401529)
Timeframe: number of days at which pain was experienced within the the 1st sevn days post -surgery

Maximum Severity of Post-operative Pain

Intervention	participants (Number)
	one day	two days	three days
IV Dexamethasone and Oral Prednisolone	36	11	3
Placebo	23	19	8

5 grades (pain free, low disability and low intensity, low disability and high intensity, high disability and moderate intensity, high disability and severly limiting) (NCT02401529)
Timeframe: The severest pain grade felt within a week

Occurence of Post-operative Nausea

Occurence of Postoperative Vomiting

Onset of 1st Post-operative Oral Intake

Intervention	participants (Number)
	Low disability and low intensity	high disability and moderate intensity	high disability and high intensity
IV Dexamethasone and Oral Prednisolone	37	13	0
Placebo	26	21	3

Intervention	participants (Number)
	yes	no
IV Dexamethasone and Oral Prednisolone	17	33
Placebo	29	21

Intervention	participants (Number)
	yes	no
IV Dexamethasone and Oral Prednisolone	25	25
Placebo	36	14

feeding onset (1st day i. surgery day, 2nd day, 3rd day) (NCT02401529)
Timeframe: Onset of 1st post-operative oral intake recorded within the 1st 3days post-surgery

Onset of Post-operative Nausea

Intervention	participants (Number)
	surgery day	1st day after surgery
IV Dexamethasone and Oral Prednisolone	46	4
Placebo	37	13

Postoperative nausea onset (no nausea, immediate, 1st day, 2nd day, 3rd day, 4th day, 5th day, 6th day, 7th day) (NCT02401529)
Timeframe: onset of 1st ocurence of nausea attack within the 1st week post-surgery

Total Number of Post-operative Vomiting Episodes

Intervention	participants (Number)
	no nausea	immediately	1st day	immediately and 1st day
IV Dexamethasone and Oral Prednisolone	33	10	4	3
Placebo	21	8	11	10

Postoperative vomiting number of attacks (no vomiting,1, 2, 3, if more specify) (NCT02401529)
Timeframe: total number of post-operative vomiting episodes which were experienced within the 1st week post-surgery

Article	Year
The efficacy of prophylactic ondansetron, droperidol, perphenazine, and metoclopramide in the prevention of nausea and vomiting after major gynecologic surgery. Anesthesia and analgesia, 1995, Volume: 81, Issue:1 Topics: Akathisia, Drug-Induced; Consciousness; Double-Blind Method; Droperidol; Female; Humans; Hypotension	1995
Prophylaxis for vomiting by children after tonsillectomy: dexamethasone versus perphenazine. Anesthesia and analgesia, 1997, Volume: 85, Issue:3 Topics: Anesthesia; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, I	1997
Controlling conditioning-related emesis in children undergoing bone marrow transplantation. Oncology nursing forum, 1997, Volume: 24, Issue:9 Topics: Adolescent; Antiemetics; Bone Marrow Transplantation; Child; Child, Preschool; Cross-Over Studies; D	1997
Perphenazine decreases vomiting by children after tonsillectomy. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1997, Volume: 44, Issue:12 Topics: Antiemetics; Child; Child, Preschool; Double-Blind Method; Humans; Perphenazine; Postoperative Compl	1997
Prophylaxis for vomiting by children after tonsillectomy: ondansetron compared with perphenazine. British journal of anaesthesia, 1998, Volume: 80, Issue:2 Topics: Ambulatory Surgical Procedures; Anesthesia, Inhalation; Anesthesia, Intravenous; Antiemetics; Child;	1998
Prophylactic antiemetics for laparoscopic cholecystectomy: a comparison of perphenazine, droperidol plus ondansetron, and droperidol plus metoclopramide. Journal of clinical anesthesia, 1998, Volume: 10, Issue:6 Topics: Adult; Aged; Antiemetics; Cholecystectomy, Laparoscopic; Double-Blind Method; Droperidol; Female; Hu	1998
The influence of cyclizine and perphenazine on the emetic effect of meptazinol. European journal of anaesthesiology, 1986, Volume: 3, Issue:1 Topics: Azepines; Clinical Trials as Topic; Cyclizine; Double-Blind Method; Female; Humans; Meptazinol; Mino	1986
[Control of postoperative vomiting with thioproperazine (Majeptil)]. Der Anaesthesist, 1970, Volume: 19, Issue:6 Topics: Adult; Antiemetics; Blood Pressure; Female; Humans; Nausea; Perphenazine; Phenothiazines; Postoperat	1970
Metoclopramide in the prevention of post-operative nausea and vomiting. The British journal of clinical practice, 1967, Sep-09, Volume: 21, Issue:9 Topics: Adult; Antiemetics; Clinical Trials as Topic; Female; Humans; Nausea; Perphenazine; Postoperative Co	1967
Metoclopramide and perphenazine in the prevention of postoperative nausea and vomiting. British journal of anaesthesia, 1970, Volume: 42, Issue:7 Topics: Amides; Benzoates; Blood Pressure; Clinical Trials as Topic; Female; Humans; Laparotomy; Nausea; Per	1970
A double-blind comparison of the anti-emetic effect during labour of metoclopramide and perphenazine. British journal of anaesthesia, 1971, Volume: 43, Issue:6 Topics: Amides; Antiemetics; Apgar Score; Benzoates; Clinical Trials as Topic; Female; Humans; Labor, Obstet	1971
Benzquinamide parenteral for the treatment of post-operative nausea and vomiting. Current therapeutic research, clinical and experimental, 1969, Volume: 11, Issue:3 Topics: Amides; Clinical Trials as Topic; Female; Humans; Injections; Male; Nausea; Perphenazine; Postoperat	1969
The action of thiethylperazine (Torecan), a new anti-emetic, compared with perphenazine (Trilafon), trimethobenzamide (Tigan), and a placebo in the suppression of postanaesthetic nausea and vomiting. Canadian Anaesthetists' Society journal, 1965, Volume: 12, Issue:6 Topics: Benzamides; Clinical Trials as Topic; Humans; Perphenazine; Placebos; Postoperative Complications; T	1965

Article	Year
Symptomatic relief of nausea and vomiting with trilafon (perphenazine); a preliminary report. The American journal of gastroenterology, 1958, Volume: 29, Issue:2 Topics: Humans; Nausea; Perphenazine; Phenothiazines; Vomiting	1958
Perphenazine in nausea and vomiting, and anxiety states. Pennsylvania medical journal (1928), 1958, Volume: 61, Issue:3 Topics: Anxiety; Nausea; Perphenazine; Phenothiazines; Vomiting	1958
Use of perphenazine in anxiety states and hyperemesis; report of 135 cases. American practitioner and digest of treatment, 1958, Volume: 9, Issue:5 Topics: Anxiety; Female; Hyperemesis Gravidarum; Perphenazine; Phenothiazines; Pregnancy; Vomiting	1958
Trials of perphenazine in the prevention of postoperative vomiting. British medical journal, 1958, Apr-19, Volume: 1, Issue:5076 Topics: Biomedical Research; Perphenazine; Phenothiazines; Postoperative Nausea and Vomiting; Surgical Proce	1958
Perphenazine as an antiemetic agent in cancer and other chronic diseases. Journal of the American Medical Association, 1958, Jul-05, Volume: 167, Issue:10 Topics: Antiemetics; Chronic Disease; Neoplasms; Perphenazine; Phenothiazines; Vomiting	1958
Perphenazine, a potent and effective antiemetic. The Journal of pharmacology and experimental therapeutics, 1958, Volume: 123, Issue:4 Topics: Antiemetics; Perphenazine; Phenothiazines; Vomiting	1958
[The use of perphenazine in several obstetrico-gynecological disorders]. Minerva medica, 1958, May-16, Volume: 49, Issue:39, Suppl. Topics: Female; Humans; Menstruation Disturbances; Pelvic Inflammatory Disease; Perphenazine; Pre-Eclampsia;	1958
Perphenazine suppositories in nausea and vomiting of pregnancy. American journal of obstetrics and gynecology, 1959, Volume: 77, Issue:2 Topics: Nausea; Perphenazine; Phenothiazines; Pregnancy; Pregnancy Complications; Suppositories; Vomiting	1959
Acute dystonic reaction to perphenazine. British medical journal, 1959, Jan-24, Volume: 1, Issue:5116 Topics: Disease; Female; Humans; Hypersensitivity; Muscles; Muscular Diseases; Perphenazine; Phenothiazines;	1959
Effect of trilafon on nausea and vomiting during labor. Obstetrics and gynecology, 1959, Volume: 13, Issue:4 Topics: Female; Humans; Nausea; Obstetric Labor Complications; Perphenazine; Phenothiazines; Pregnancy; Vomi	1959
Perphenazine in urology and surgery. American practitioner and digest of treatment, 1959, Volume: 10, Issue:5 Topics: Hiccup; Humans; Nausea; Perphenazine; Phenothiazines; Urinary Tract; Urologic Diseases; Urology; Vom	1959
Severe side reaction to therapeutic dosage of perphenazine. The New England journal of medicine, 1959, May-28, Volume: 260, Issue:22 Topics: Perphenazine; Phenothiazines; Pregnancy; Pregnancy Complications; Vomiting	1959
Control of postoperative nausea and vomiting. A double blind study of perphenazine (Trilafon) in two hundred and thirty-six patients. The Ohio State medical journal, 1961, Volume: 57 Topics: Double-Blind Method; Humans; Nausea; Perphenazine; Postoperative Care; Postoperative Nausea and Vomi	1961
Perphenazine as a prophylactic antiemetic in surgery. A double-blind study among 580 patients. The American surgeon, 1961, Volume: 27 Topics: Antiemetics; Biomedical Research; Double-Blind Method; Perphenazine; Surgical Procedures, Operative;	1961
Control of postoperative vomiting with perphenazine (Trilafon). A double-blind study. Acta anaesthesiologica Scandinavica, 1960, Volume: 4 Topics: Biomedical Research; Double-Blind Method; Humans; Perphenazine; Postoperative Care; Postoperative Na	1960
Reaction to trilafon. Texas state journal of medicine, 1959, Volume: 55 Topics: Hypersensitivity; Perphenazine; Phenothiazines; Vomiting	1959
Effect of perphenazine on postoperative emesis. Archives of surgery (Chicago, Ill. : 1960), 1959, Volume: 79 Topics: Perphenazine; Postoperative Nausea and Vomiting; Surgical Procedures, Operative; Vomiting	1959
[The use of perphenazine in treatment of postoperative vomiting]. Minerva chirurgica, 1960, Mar-31, Volume: 15 Topics: Perphenazine; Postoperative Nausea and Vomiting; Surgical Procedures, Operative; Vomiting	1960
[Clonic cramps after consumption of a small dose of perphenazine (Trilafon) for emesis gravidarum]. Nederlandsch tijdschrift voor verloskunde en gynaecologie, 1961, Volume: 61 Topics: Biological Phenomena; Female; Gastrointestinal Contents; Humans; Hyperemesis Gravidarum; Muscle Cram	1961
[Perphenazine (Trilafon) in postanesthetic vomiting]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1962, Jun-15, Volume: 82 Topics: Perphenazine; Surgical Procedures, Operative; Vomiting	1962
THE EFFECTIVENESS OF ANTI-EMETIC AGENTS: A COMPARISON OF THE ANTI-EMETIC ACTIVITY OF TRIFLUOPROMAZINE (VESPRIN), PERPHENAZINE (TRILAFON), AND TRIFLUOPERAZINE (STELAZINE) WITH THAT OF DIMENHYDRINATE (GRAVOL) IN POSTANESTHETIC VOMITING. Canadian Anaesthetists' Society journal, 1963, Volume: 10 Topics: Anesthesia; Anesthesiology; Antiemetics; Dimenhydrinate; Humans; Perphenazine; Postoperative Complic	1963
[THE ANTIEMETIC EFFECT OF PERPHENAZINE. CLINICAL STUDY IN GENERAL MEDICINE]. Lyon medical, 1963, Dec-15, Volume: 210 Topics: Alcoholism; Antiemetics; Drug Hypersensitivity; Gastroenterology; Humans; Peptic Ulcer; Perphenazine	1963
EFFECT OF ANTIEMETICS AND OTHER COMPOUNDS ON PROTOVERATRINE INDUCED EMESIS IN DOGS. Journal of pharmaceutical sciences, 1964, Volume: 53 Topics: Antiemetics; Atropine; Benzamides; Dogs; Haloperidol; Meclizine; Niacin; Perphenazine; Pharmacology;	1964
[ANTIEMETIC EFFECT OF ETAPERAZINE IN COMBINED THERAPY OF VOMITING IN PREGNANCY]. Sovetskaia meditsina, 1964, Volume: 28 Topics: Antiemetics; Drug Therapy; Female; Humans; Perphenazine; Pregnancy; Pregnancy Complications; Psychot	1964
PERPHENAZIN (TRILAFON) IN THE PROPHYLAXIS OF NAUSEA AND VOMITING FOLLOWING ACUTE MYOCARDIAL INFARCT. Acta medica Scandinavica, 1965, Volume: 177 Topics: Drug Therapy; Humans; Myocardial Infarction; Myocardium; Nausea; Perphenazine; Vomiting	1965
[On clinical experiences in the control of the symptom complex vertigo-nausea-emesis]. Therapie der Gegenwart, 1959, Volume: 98 Topics: Dizziness; Humans; Nausea; Perphenazine; Vertigo; Vomiting	1959
Value of perphenazine in control of postanaesthetic vomiting. The Journal of the Egyptian Medical Association, 1959, Volume: 42 Topics: Biomedical Research; Perphenazine; Surgical Procedures, Operative; Vomiting	1959
Postoperative nausea and vomiting: the response to anti-emetic drugs with special reference to cyclizine and perphenazine. Canadian Anaesthetists' Society journal, 1960, Volume: 7 Topics: Anti-Allergic Agents; Antiemetics; Cyclizine; Histamine H1 Antagonists; Humans; Perphenazine; Postop	1960
The effect of selected drugs on first-stage radioemesis in beagle dogs. Radiation research, 1979, Volume: 78, Issue:2 Topics: Amifostine; Amphetamine; Animals; Antiemetics; Body Weight; Chlorpromazine; Dimenhydrinate; Diphenhy	1979
Treatment of phenothiazine drug intoxication with benztropine. Archives of disease in childhood, 1974, Volume: 49, Issue:8 Topics: Antiparkinson Agents; Benztropine; Child; Female; Humans; Infant; Injections, Intravenous; Male; Mov	1974
[Phentonium plus perphenazine?]. Minerva medica, 1974, May-02, Volume: 65, Issue:33 Topics: Adolescent; Adult; Affective Symptoms; Analysis of Variance; Anxiety; Atropine; Biphenyl Compounds;	1974
Emesis induced by the intracerebroventricular administration of hydergine and mechlorethamine hydrochloride. The Journal of pharmacology and experimental therapeutics, 1966, Volume: 154, Issue:2 Topics: Animals; Cerebral Ventricles; Chlorpromazine; Dogs; Emetics; Ergoloid Mesylates; Mechlorethamine; Pe	1966
Chlorpromazine and the eye of the dog. VI. A comparison of phenothiazine tranquilizers. Experimental and molecular pathology, 1972, Volume: 16, Issue:2 Topics: Administration, Oral; Animals; Chlorpromazine; Cornea; Corneal Opacity; Cytoplasmic Granules; Depres	1972
[Enteral effect of peruvoside]. Arzneimittel-Forschung, 1968, Volume: 18, Issue:12 Topics: Animals; Bile; Cardiac Glycosides; Cats; Dogs; Dosage Forms; Methods; Perphenazine; Vomiting	1968
[Postoperative vomiting and pain]. Acta anaesthesiologica, 1968, Volume: 19 Topics: Chlordiazepoxide; Female; Humans; Hypnotics and Sedatives; Male; Pain; Perphenazine; Postoperative C	1968
Perphenazine dystonia presenting as recurrent dislocation of the jaw. The Journal of laryngology and otology, 1969, Volume: 83, Issue:1 Topics: Adult; Female; Humans; Joint Dislocations; Mandible; Masticatory Muscles; Muscular Diseases; Parasym	1969
Influence of antiparkinson drugs and amphetamine on some pharmacological effects of phenothiazine derivatives used as neuroleptics. Psychopharmacologia, 1964, Sep-11, Volume: 6, Issue:3 Topics: Amphetamine; Animals; Apomorphine; Avoidance Learning; Behavior, Animal; Body Temperature; Catalepsy	1964

Intervention	participants (Number)
	no vomiting	once	twice	three times	more than 3 times
IV Dexamethasone and Oral Prednisolone	25	13	7	4	1
Placebo	14	9	19	8	0

perphenazine and Vomiting