perphenazine has been researched along with Parkinson Disease in 15 studies
Perphenazine: An antipsychotic phenothiazine derivative with actions and uses similar to those of CHLORPROMAZINE.
perphenazine : A phenothiazine derivative in which the phenothiazine tricycle carries a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at N-10.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (93.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stegmeier-Petroianu, A | 1 |
| Petroianu, GA | 1 |
| GOLDSCHMIDT, D | 1 |
| MOTOSUGI, M | 1 |
| SATO, K | 1 |
| Sheppard, C | 1 |
| Merlis, S | 1 |
| Hale, MS | 1 |
| Bellizzi, J | 1 |
| Birkmayer, W | 1 |
| Bruck, H | 1 |
| Gerstenbrand, F | 1 |
| Gnad, H | 1 |
| Gründig, E | 1 |
| Prosenz, P | 1 |
| Turunen, S | 1 |
| Achté, KA | 1 |
| Pakkenberg, H | 1 |
| Bottcher, J | 1 |
| Patni, SK | 1 |
| Dandiya, PC | 2 |
| Brown, DM | 1 |
| Hughes, BO | 1 |
| Marsden, CD | 1 |
| Meadows, JC | 1 |
| Spicer, B | 1 |
| Bhargava, LP | 1 |
| Hader, M | 1 |
| Salzberger, GJ | 1 |
| Ekdawi, MY | 1 |
| Fowke, R | 1 |
1 trial available for perphenazine and Parkinson Disease
| Article | Year |
|---|---|
Some initial animal and human pharmacological studies with benapryzine (BRL 1288).
Topics: Acetylcholine; Aged; Animals; Antiparkinson Agents; Benzilates; Clinical Trials as Topic; Dose-Respo | 1973 |
14 other studies available for perphenazine and Parkinson Disease
| Article | Year |
|---|---|
Hiccups and dopamine.
Topics: Amantadine; Antiparkinson Agents; Benzothiazoles; Dopamine Agonists; Dopamine Antagonists; Hiccup; H | 2008 |
[Experiences and conclusions in regard to the use of hirepin. Part I].
Topics: Chlorpromazine; Parkinson Disease; Perphenazine; Reserpine | 1960 |
[A case report showing side effect of perphenazine in short term therapy].
Topics: Humans; Parkinson Disease; Perphenazine | 1962 |
Drug-induced extrapyramidal symptoms: their incidence and treatment.
Topics: Chlorpromazine; Chlorprothixene; Extrapyramidal Tracts; Female; Fluphenazine; Humans; Male; Parasymp | 1967 |
Low dose perphenazine and levodopa/carbidopa therapy in a patient with Parkinsonism and a psychotic illness.
Topics: Carbidopa; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Levodopa; Male; Midd | 1980 |
[Experimental findings and new aspects in extrapyramidal diseases].
Topics: 5-Hydroxytryptophan; Blood Pressure; Body Temperature Regulation; Chorea; Dihydroxyphenylalanine; Do | 1966 |
[Comparative biochemical studies in organic parkinsonian syndromes and drug induced parkinsonian syndromes].
Topics: Alanine Transaminase; Aspartate Aminotransferases; Biochemical Phenomena; Biochemistry; Chlorpromazi | 1966 |
The bucco-linguo-masticatory syndrome as a side-effect of neuroleptics therapy.
Topics: Adult; Aged; Brain Damage, Chronic; Cheek; Chlorpromazine; Chlorprothixene; Clopenthixol; Female; Ha | 1967 |
Corpus striatum in paralysis agitans and in perphenazine-injected rats.
Topics: Aged; Amphetamine; Amphetamines; Animals; Basal Ganglia; Caudate Nucleus; Chlorpromazine; Corpus Str | 1974 |
The influence of monoamine oxidase inhibitors and some other antidepressants on the anti-parkinsonian activity of sub-effective doses of diphenylhydramine in rats and mice.
Topics: Animals; Antidepressive Agents; Catatonia; Diphenhydramine; Humans; Mice; Monoamine Oxidase Inhibito | 1972 |
The antiparkinsonian activity of monoamine oxidase inhibitors and other agents in rats and mice.
Topics: Animals; Dextroamphetamine; Diphenhydramine; Imipramine; Iproniazid; Isocarboxazid; Mice; Monoamine | 1968 |
Antiparkinsonism medication for the phenothiazine-induced pyramidal-extrapyramidal syndrome in elderly brain-damaged patients.
Topics: Aged; Brain Damage, Chronic; Chlorpromazine; Female; Humans; Male; Parkinson Disease; Perphenazine; | 1965 |
Control of agitation in institutionalized aged females.
Topics: Aged; Female; Humans; Hypertension; Mental Disorders; Middle Aged; Parkinson Disease; Perphenazine | 1966 |
A controlled trial of anti-Parkinson drugs in drug-induced Parkinsonism.
Topics: Adolescent; Adult; Chlorpromazine; Haloperidol; Humans; Middle Aged; Orphenadrine; Parasympatholytic | 1966 |