perphenazine has been researched along with Huntington Disease in 7 studies
Perphenazine: An antipsychotic phenothiazine derivative with actions and uses similar to those of CHLORPROMAZINE.
perphenazine : A phenothiazine derivative in which the phenothiazine tricycle carries a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at N-10.
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| SHTERNBERG, EIa | 1 |
| SMULEVICH, AB | 1 |
| LASCELLES, CF | 1 |
| MERSKEY, H | 1 |
| RICE, T | 1 |
| TROUPE, A | 1 |
| Rosin, AJ | 1 |
| Shoulson, I | 1 |
| Chase, TN | 1 |
| Fahn, S | 1 |
| Mattsson, B | 1 |
| Persson, SA | 1 |
1 review available for perphenazine and Huntington Disease
| Article | Year |
|---|---|
Huntington's disease.
Topics: Adult; Child; Chlordiazepoxide; Diazepam; Dopamine; Female; Genetic Counseling; Haloperidol; Humans; | 1975 |
1 trial available for perphenazine and Huntington Disease
| Article | Year |
|---|---|
Treatment of choreic movements with perphenazine.
Topics: Adult; Aged; Chorea; Clinical Trials as Topic; Evaluation Studies as Topic; Female; Follow-Up Studie | 1972 |
5 other studies available for perphenazine and Huntington Disease
| Article | Year |
|---|---|
[Experience in the use of neuroleptic substances in chronic progressive chorea (Huntington's chorea)].
Topics: Antipsychotic Agents; Chorea; Humans; Huntington Disease; Perphenazine; Reserpine | 1963 |
HUNTINGTON'S CHOREA.
Topics: Barbiturates; Cerebral Cortex; Chlorpromazine; Chorea; Drug Therapy; Huntington Disease; Pathology; | 1964 |
An investigation of some therapeutic and physiological effects of perphenazine in Huntington's chorea.
Topics: Chorea; Humans; Huntington Disease; Perphenazine | 1961 |
Treatment of dyskinetic and choreatic movement disorders in adults.
Topics: Adult; Aged; Athetosis; Chorea; Dose-Response Relationship, Drug; Drug Therapy, Combination; Dyskine | 1978 |
Cerebrospinal homovanillic acid and 5-hydroxyindoleacetic acid in huntington's chorea.
Topics: Adult; Chlormethiazole; Chlorpromazine; Female; Fluphenazine; Haloperidol; Homovanillic Acid; Humans | 1974 |