perphenazine has been researched along with Depressive Disorder, Major in 15 studies
Perphenazine: An antipsychotic phenothiazine derivative with actions and uses similar to those of CHLORPROMAZINE.
perphenazine : A phenothiazine derivative in which the phenothiazine tricycle carries a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at N-10.
Depressive Disorder, Major: Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with DSM-IV-defined schizophrenia (N = 1,460) were assigned to treatment with a first-generation antipsychotic (perphenazine) or one of 4 second-generation drugs (olanzapine, quetiapine, risperidone, or ziprasidone) and followed for up to 18 months (phase 1)." | 9.15 | Impact of second-generation antipsychotics and perphenazine on depressive symptoms in a randomized trial of treatment for chronic schizophrenia. ( Addington, DE; Davis, SM; Lieberman, JA; McEvoy, JP; Mohamed, S; Rosenheck, RA; Stroup, TS; Swartz, MS, 2011) |
| "A 51 year old woman sustained ventricular fibrillation while receiving perphenazine and protriptyline." | 7.66 | Electrophysiologic studies of perphenazine and protriptyline in a patient with psychotropic drug-induced ventricular fibrillation. ( Jewell, GM; Leier, CV; Magorien, RD; Schaal, SF, 1979) |
| "Patients with DSM-IV-defined schizophrenia (N = 1,460) were assigned to treatment with a first-generation antipsychotic (perphenazine) or one of 4 second-generation drugs (olanzapine, quetiapine, risperidone, or ziprasidone) and followed for up to 18 months (phase 1)." | 5.15 | Impact of second-generation antipsychotics and perphenazine on depressive symptoms in a randomized trial of treatment for chronic schizophrenia. ( Addington, DE; Davis, SM; Lieberman, JA; McEvoy, JP; Mohamed, S; Rosenheck, RA; Stroup, TS; Swartz, MS, 2011) |
| "A 51 year old woman sustained ventricular fibrillation while receiving perphenazine and protriptyline." | 3.66 | Electrophysiologic studies of perphenazine and protriptyline in a patient with psychotropic drug-induced ventricular fibrillation. ( Jewell, GM; Leier, CV; Magorien, RD; Schaal, SF, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (80.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Addington, DE | 1 |
| Mohamed, S | 1 |
| Rosenheck, RA | 1 |
| Davis, SM | 1 |
| Stroup, TS | 1 |
| McEvoy, JP | 1 |
| Swartz, MS | 1 |
| Lieberman, JA | 1 |
| HARDI, I | 1 |
| Castrioto, A | 1 |
| Tambasco, N | 1 |
| Rossi, A | 1 |
| Calabresi, P | 1 |
| Ross, J | 1 |
| Jaquith, WL | 1 |
| Nail, HR | 1 |
| Smith, BS | 1 |
| Taylor, MR | 1 |
| Bourgeois, M | 1 |
| Magorien, RD | 1 |
| Jewell, GM | 1 |
| Schaal, SF | 1 |
| Leier, CV | 1 |
| Loeb, C | 1 |
| Roccatagliatà, G | 1 |
| Besio, G | 1 |
| Kamen, S | 1 |
| Savitsky, E | 1 |
| Svestka, J | 2 |
| Rodovà, A | 3 |
| Nàhunek, K | 3 |
| Hádlík, J | 2 |
| Misurec, J | 1 |
| Vanýsek, J | 1 |
| Fracchia, J | 1 |
| Sheppard, C | 1 |
| Merlis, S | 1 |
| Radzuweit, H | 1 |
| Knorr, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparative Effectiveness of Antipsychotic Medications in Patients With Schizophrenia (CATIE Schizophrenia Trial)[NCT00014001] | Phase 4 | 1,600 participants | Interventional | 2000-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for perphenazine and Depressive Disorder, Major
| Article | Year |
|---|---|
Discontinuation of lithium augmentation in geriatric patients with unipolar depression: a systematic review.
Topics: Aged; Antidepressive Agents; Antipsychotic Agents; Depressive Disorder, Major; Drug Therapy, Combina | 2008 |
6 trials available for perphenazine and Depressive Disorder, Major
| Article | Year |
|---|---|
Impact of second-generation antipsychotics and perphenazine on depressive symptoms in a randomized trial of treatment for chronic schizophrenia.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Chronic Disease; Comorbidity; Depression; Depressive | 2011 |
Psychopharmacology in the aged. Discussion.
Topics: Age Factors; Aged; Amitriptyline; Antipsychotic Agents; Bipolar Disorder; Brain Damage, Chronic; Dep | 1974 |
Comparison of the short-term therapeutic effect of oxyprothepine and perphenazine in schizophrenic patients. A controlled study.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Depressive Disorder, Major; Dibenzothiepins; Huma | 1973 |
[Comparison of triperidol with perphenazine in schizophrenic psychoses. Effect on the photomyoclonic threshold].
Topics: Adolescent; Adult; Antidepressive Agents; Butyrophenones; Clinical Trials as Topic; Depressive Disor | 1970 |
[Controlled studies with thiothixene and perphenazine in schizophrenic psychoses].
Topics: Adult; Affective Symptoms; Clinical Trials as Topic; Depressive Disorder, Major; Female; Humans; Mal | 1970 |
Combination medications in psychiatric treatment: patterns in a group of elderly hospital patients.
Topics: Age Factors; Aged; Amitriptyline; Antidepressive Agents; Antihypertensive Agents; Antisocial Persona | 1971 |
8 other studies available for perphenazine and Depressive Disorder, Major
| Article | Year |
|---|---|
[DYNAMIC STUDIES ON DRAWING IN THE COURSE OF TREATMENT WITH PSYCHOTROPIC AGENTS].
Topics: Antisocial Personality Disorder; Bipolar Disorder; Depressive Disorder, Major; Imipramine; Mental Di | 1964 |
Acute dystonia induced by the combination of midodrine and perphenazine.
Topics: Acute Disease; Adrenergic alpha-1 Receptor Agonists; Antipsychotic Agents; Cytochrome P-450 CYP2D6; | 2008 |
Perphenazine therapy among outpatients.
Topics: Bipolar Disorder; Brain Damage, Chronic; Depressive Disorder, Major; Female; Humans; Intellectual Di | 1967 |
[Study of an antidepressive agent in psychiatry: Mutabon F].
Topics: Adjustment Disorders; Adolescent; Adult; Aged; Amitriptyline; Anxiety Disorders; Bipolar Disorder; D | 1967 |
Electrophysiologic studies of perphenazine and protriptyline in a patient with psychotropic drug-induced ventricular fibrillation.
Topics: Depressive Disorder, Major; Dibenzocycloheptenes; Electrocardiography; Female; Heart Conduction Syst | 1979 |
[Variations in the urinary level of MHPG in depressive syndromes].
Topics: Adult; Age Factors; Aged; Antidepressive Agents, Tricyclic; Anxiety; Depression; Depressive Disorder | 1979 |
Tardive dyskinesia. A significant syndrome for geriatric dentistry.
Topics: Aged; Arteriosclerosis; Bruxism; Chlorpromazine; Dementia; Denture, Complete; Depression; Depressive | 1975 |
[Influencing of biological and immunologic pregnancy reactions by psychotropic drugs].
Topics: Adolescent; Adult; Aged; Butyrophenones; Chlorpromazine; Dementia; Depressive Disorder, Major; Dysau | 1969 |