perphenazine has been researched along with Dementia in 9 studies
Perphenazine: An antipsychotic phenothiazine derivative with actions and uses similar to those of CHLORPROMAZINE.
perphenazine : A phenothiazine derivative in which the phenothiazine tricycle carries a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at N-10.
Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study of 45 elderly patients suffering from dementia and treated with perphenazine, 5 patients who were prospectively identified as poor P450 2D6 metabolizers had significantly greater side effects than the 40 extensive metabolizers." | 3.69 | Prospective cytochrome P450 phenotyping for neuroleptic treatment in dementia. ( Altieri, LP; Mulsant, BH; Perel, JM; Pollock, BG; Rosen, J; Sweet, RA, 1995) |
| "Citalopram was found to be more efficacious than placebo in the short-term hospital treatment of psychotic symptoms and behavioral disturbances in nondepressed, demented patients." | 2.70 | Comparison of citalopram, perphenazine, and placebo for the acute treatment of psychosis and behavioral disturbances in hospitalized, demented patients. ( Bharucha, A; Chew, ML; Huber, KA; Jacob, NJ; Kastango, KB; Marin, R; Mazumdar, S; Mulsant, BH; Pollock, BG; Rosen, J; Sweet, RA, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (66.67) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| AYD, FJ | 1 |
| ANDERSEN, E | 1 |
| HANSEN, G | 1 |
| SOULAIRAC, A | 1 |
| GEIER, S | 1 |
| MOREL, P | 1 |
| FILLIOZAT, AM | 1 |
| FILLIOZAT, R | 1 |
| CHAVANNES, N | 1 |
| Bourgeois, M | 1 |
| Pollock, BG | 3 |
| Mulsant, BH | 3 |
| Sweet, RA | 3 |
| Rosen, J | 3 |
| Altieri, LP | 1 |
| Perel, JM | 1 |
| Sorisio, D | 1 |
| Kirshner, M | 1 |
| Henteleff, R | 1 |
| DeMichele, MA | 1 |
| Mazumdar, S | 1 |
| Bharucha, A | 1 |
| Marin, R | 1 |
| Jacob, NJ | 1 |
| Huber, KA | 1 |
| Kastango, KB | 1 |
| Chew, ML | 1 |
| Kamen, S | 1 |
| Radzuweit, H | 1 |
| Knorr, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Continuation Pharmacotherapy for Agitation of Dementia[NCT00073658] | Phase 2 | 137 participants | Interventional | 2000-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for perphenazine and Dementia
| Article | Year |
|---|---|
Comparison of citalopram, perphenazine, and placebo for the acute treatment of psychosis and behavioral disturbances in hospitalized, demented patients.
Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Behavioral Symptoms; Citalopram; Dementia; Donepezil; | 2002 |
8 other studies available for perphenazine and Dementia
| Article | Year |
|---|---|
The treatment of anxiety, agitation and excitement in the aged; a preliminary report on trilafon.
Topics: Aged; Anxiety; Dementia; Humans; Mental Disorders; Perphenazine; Psychomotor Agitation; Psychotic Di | 1957 |
[Trilafon & states of excitement in aged psychotics].
Topics: Dementia; Humans; Mental Disorders; Perphenazine; Phenothiazines; Psychotic Disorders | 1958 |
[A neuroleptic derivative of phenothiazine: perphenazine].
Topics: Alcoholism; Antipsychotic Agents; Character; Delusions; Dementia; Humans; Perphenazine; Phenothiazin | 1963 |
[Study of an antidepressive agent in psychiatry: Mutabon F].
Topics: Adjustment Disorders; Adolescent; Adult; Aged; Amitriptyline; Anxiety Disorders; Bipolar Disorder; D | 1967 |
Prospective cytochrome P450 phenotyping for neuroleptic treatment in dementia.
Topics: Aged; Alzheimer Disease; Cytochrome P-450 Enzyme System; Dementia; Female; Humans; Male; Middle Aged | 1995 |
Pharmacologic profile of perphenazine's metabolites.
Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Biotransformation; Brain; Cell Line, Transformed; Cyt | 2000 |
Tardive dyskinesia. A significant syndrome for geriatric dentistry.
Topics: Aged; Arteriosclerosis; Bruxism; Chlorpromazine; Dementia; Denture, Complete; Depression; Depressive | 1975 |
[Influencing of biological and immunologic pregnancy reactions by psychotropic drugs].
Topics: Adolescent; Adult; Aged; Butyrophenones; Chlorpromazine; Dementia; Depressive Disorder, Major; Dysau | 1969 |