perphenazine and Complication, Postoperative studies

Perphenazine: An antipsychotic phenothiazine derivative with actions and uses similar to those of CHLORPROMAZINE.
perphenazine : A phenothiazine derivative in which the phenothiazine tricycle carries a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at N-10.

Research Excerpts

Excerpt	Relevance	Reference
"The effects of dexamethasone and perphenazine on vomiting after tonsillectomy in children were compared in 226 healthy children aged 2-12 yr."	9.08	Prophylaxis for vomiting by children after tonsillectomy: dexamethasone versus perphenazine. ( Roberts, DJ; Splinter, W, 1997)
"To test the hypothesis that perphenazine decreases the incidence of vomiting by children after tonsillectomy."	9.08	Perphenazine decreases vomiting by children after tonsillectomy. ( Roberts, DJ; Splinter, WM, 1997)
"We have compared the effects of ondansetron and perphenazine on vomiting after tonsillectomy in 216 healthy children, aged 2-12 yr."	9.08	Prophylaxis for vomiting by children after tonsillectomy: ondansetron compared with perphenazine. ( Rhine, EJ; Splinter, WM, 1998)
"Metoclopramide was ineffective."	6.68	The efficacy of prophylactic ondansetron, droperidol, perphenazine, and metoclopramide in the prevention of nausea and vomiting after major gynecologic surgery. ( Clark, K; Cronin, MK; Darvish, AH; Desilva, PH; McDonald, SM, 1995)
"The effects of dexamethasone and perphenazine on vomiting after tonsillectomy in children were compared in 226 healthy children aged 2-12 yr."	5.08	Prophylaxis for vomiting by children after tonsillectomy: dexamethasone versus perphenazine. ( Roberts, DJ; Splinter, W, 1997)
"To test the hypothesis that perphenazine decreases the incidence of vomiting by children after tonsillectomy."	5.08	Perphenazine decreases vomiting by children after tonsillectomy. ( Roberts, DJ; Splinter, WM, 1997)
"We have compared the effects of ondansetron and perphenazine on vomiting after tonsillectomy in 216 healthy children, aged 2-12 yr."	5.08	Prophylaxis for vomiting by children after tonsillectomy: ondansetron compared with perphenazine. ( Rhine, EJ; Splinter, WM, 1998)
"To compare the prophylactic administration of ondansetron plus droperidol, droperidol plus metoclopramide, and perphenazine to determine effects on postoperative nausea, vomiting, and sedation after laparoscopic cholecystectomy."	5.08	Prophylactic antiemetics for laparoscopic cholecystectomy: a comparison of perphenazine, droperidol plus ondansetron, and droperidol plus metoclopramide. ( Freiberger, D; Gosnell, JL; Steinbrook, RA, 1998)
"An 8-year-old child was given perphenazine to prevent vomiting after surgery and developed an acute dystonic reaction; There were features of both tetany and tetanus without any of the classical features of extrapyramidal disturbance."	3.65	Tetany, tetanus or drug reaction? A case report. ( Smith, WD; Tobias, MA, 1976)
"Metoclopramide was ineffective."	2.68	The efficacy of prophylactic ondansetron, droperidol, perphenazine, and metoclopramide in the prevention of nausea and vomiting after major gynecologic surgery. ( Clark, K; Cronin, MK; Darvish, AH; Desilva, PH; McDonald, SM, 1995)

Research

Studies (17)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Average Amount of Meal Per Day

Average Frequency of Meals Per Day

Timeframe	Studies, this research(%)	All Research%
pre-1990	12 (70.59)	18.7374
1990's	5 (29.41)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
PURKIS, IE	2
ISHII, M	1
Desilva, PH	1
Darvish, AH	1
McDonald, SM	1
Cronin, MK	1
Clark, K	1
Splinter, W	1
Roberts, DJ	2
Splinter, WM	2
Rhine, EJ	1
Steinbrook, RA	1
Gosnell, JL	1
Freiberger, D	1
Boliston, TA	1
Smith, WD	1
Tobias, MA	1
Lind, B	2
Roland, P	1
Grimeland, J	1
Tunstall, ME	1
Ogg, TW	1
Andersen, R	1
Handley, AJ	1
Breivik, H	1
Larrauri, RM	1
Pagliarini, G	1
Pollazzon, G	1
Ridolfi, C	1
Rizzi, R	2
Vacondio, L	1
Cecconello, D	1
Bissanti, A	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Effect of Steroids on Post-tonsillectomy Morbidities[NCT02401529]	Phase 2	100 participants (Actual)	Interventional	2013-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	participants (Number)
	inadequate	adequate
IV Dexamethasone and Oral Prednisolone	16	34
Placebo	27	23

average frequency of meals (1 meal, 2 meals, if more specify) (NCT02401529)
Timeframe: average number of meals consumed per day for the 1st three days post-surgery

Duration of Post-operative Nausea

Intervention	participants (Number)
	1 meal	2 meals	3 meals
IV Dexamethasone and Oral Prednisolone	2	20	28
Placebo	1	34	15

Postoperative nausea duration (no nausea,1 day, 2 days, 3 days, 4 days, if more specify) (NCT02401529)
Timeframe: 7 days

Duration of Post-operative Pain

Intervention	participants (Number)
	no nausea	one day	two days	three days
IV Dexamethasone and Oral Prednisolone	33	3	14	0
Placebo	21	8	15	6

4 selections (1 day, 2 days, 3 days, if more specify) (NCT02401529)
Timeframe: number of days at which pain was experienced within the the 1st sevn days post -surgery

Maximum Severity of Post-operative Pain

Intervention	participants (Number)
	one day	two days	three days
IV Dexamethasone and Oral Prednisolone	36	11	3
Placebo	23	19	8

5 grades (pain free, low disability and low intensity, low disability and high intensity, high disability and moderate intensity, high disability and severly limiting) (NCT02401529)
Timeframe: The severest pain grade felt within a week

Occurence of Post-operative Nausea

Occurence of Postoperative Vomiting

Onset of 1st Post-operative Oral Intake

Intervention	participants (Number)
	Low disability and low intensity	high disability and moderate intensity	high disability and high intensity
IV Dexamethasone and Oral Prednisolone	37	13	0
Placebo	26	21	3

Intervention	participants (Number)
	yes	no
IV Dexamethasone and Oral Prednisolone	17	33
Placebo	29	21

Intervention	participants (Number)
	yes	no
IV Dexamethasone and Oral Prednisolone	25	25
Placebo	36	14

feeding onset (1st day i. surgery day, 2nd day, 3rd day) (NCT02401529)
Timeframe: Onset of 1st post-operative oral intake recorded within the 1st 3days post-surgery

Onset of Post-operative Nausea

Intervention	participants (Number)
	surgery day	1st day after surgery
IV Dexamethasone and Oral Prednisolone	46	4
Placebo	37	13

Postoperative nausea onset (no nausea, immediate, 1st day, 2nd day, 3rd day, 4th day, 5th day, 6th day, 7th day) (NCT02401529)
Timeframe: onset of 1st ocurence of nausea attack within the 1st week post-surgery

Total Number of Post-operative Vomiting Episodes

Intervention	participants (Number)
	no nausea	immediately	1st day	immediately and 1st day
IV Dexamethasone and Oral Prednisolone	33	10	4	3
Placebo	21	8	11	10

Postoperative vomiting number of attacks (no vomiting,1, 2, 3, if more specify) (NCT02401529)
Timeframe: total number of post-operative vomiting episodes which were experienced within the 1st week post-surgery

Article	Year
The efficacy of prophylactic ondansetron, droperidol, perphenazine, and metoclopramide in the prevention of nausea and vomiting after major gynecologic surgery. Anesthesia and analgesia, 1995, Volume: 81, Issue:1 Topics: Akathisia, Drug-Induced; Consciousness; Double-Blind Method; Droperidol; Female; Humans; Hypotension	1995
Prophylaxis for vomiting by children after tonsillectomy: dexamethasone versus perphenazine. Anesthesia and analgesia, 1997, Volume: 85, Issue:3 Topics: Anesthesia; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, I	1997
Perphenazine decreases vomiting by children after tonsillectomy. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1997, Volume: 44, Issue:12 Topics: Antiemetics; Child; Child, Preschool; Double-Blind Method; Humans; Perphenazine; Postoperative Compl	1997
Prophylaxis for vomiting by children after tonsillectomy: ondansetron compared with perphenazine. British journal of anaesthesia, 1998, Volume: 80, Issue:2 Topics: Ambulatory Surgical Procedures; Anesthesia, Inhalation; Anesthesia, Intravenous; Antiemetics; Child;	1998
Prophylactic antiemetics for laparoscopic cholecystectomy: a comparison of perphenazine, droperidol plus ondansetron, and droperidol plus metoclopramide. Journal of clinical anesthesia, 1998, Volume: 10, Issue:6 Topics: Adult; Aged; Antiemetics; Cholecystectomy, Laparoscopic; Double-Blind Method; Droperidol; Female; Hu	1998
[Control of postoperative vomiting with thioproperazine (Majeptil)]. Der Anaesthesist, 1970, Volume: 19, Issue:6 Topics: Adult; Antiemetics; Blood Pressure; Female; Humans; Nausea; Perphenazine; Phenothiazines; Postoperat	1970
Piritramide and pethidine. A comparison of their use as supplements in general anaesthesia. Anaesthesia, 1974, Volume: 29, Issue:6 Topics: Anesthesia, General; Female; Humans; Hypotension; Isonipecotic Acids; Meperidine; Nitriles; Pain, Po	1974
Metoclopramide in the prevention of post-operative nausea and vomiting. The British journal of clinical practice, 1967, Sep-09, Volume: 21, Issue:9 Topics: Adult; Antiemetics; Clinical Trials as Topic; Female; Humans; Nausea; Perphenazine; Postoperative Co	1967
Metoclopramide and perphenazine in the prevention of postoperative nausea and vomiting. British journal of anaesthesia, 1970, Volume: 42, Issue:7 Topics: Amides; Benzoates; Blood Pressure; Clinical Trials as Topic; Female; Humans; Laparotomy; Nausea; Per	1970
Benzquinamide parenteral for the treatment of post-operative nausea and vomiting. Current therapeutic research, clinical and experimental, 1969, Volume: 11, Issue:3 Topics: Amides; Clinical Trials as Topic; Female; Humans; Injections; Male; Nausea; Perphenazine; Postoperat	1969
The action of thiethylperazine (Torecan), a new anti-emetic, compared with perphenazine (Trilafon), trimethobenzamide (Tigan), and a placebo in the suppression of postanaesthetic nausea and vomiting. Canadian Anaesthetists' Society journal, 1965, Volume: 12, Issue:6 Topics: Benzamides; Clinical Trials as Topic; Humans; Perphenazine; Placebos; Postoperative Complications; T	1965
[Clinico-statistical pluricentral study of postoperative pain]. Minerva anestesiologica, 1968, Volume: 34, Issue:5 Topics: Aminopyrine; Analgesics; Barbiturates; Chlordiazepoxide; Female; Humans; Imidazoles; Italy; Ketones;	1968

Article	Year
THE EFFECTIVENESS OF ANTI-EMETIC AGENTS: A COMPARISON OF THE ANTI-EMETIC ACTIVITY OF TRIFLUOPROMAZINE (VESPRIN), PERPHENAZINE (TRILAFON), AND TRIFLUOPERAZINE (STELAZINE) WITH THAT OF DIMENHYDRINATE (GRAVOL) IN POSTANESTHETIC VOMITING. Canadian Anaesthetists' Society journal, 1963, Volume: 10 Topics: Anesthesia; Anesthesiology; Antiemetics; Dimenhydrinate; Humans; Perphenazine; Postoperative Complic	1963
Letter: Side-effects of perphenazine. Lancet (London, England), 1975, Jul-12, Volume: 2, Issue:7924 Topics: Atropine; Humans; Nausea; Perphenazine; Postoperative Complications	1975
Tetany, tetanus or drug reaction? A case report. British journal of anaesthesia, 1976, Volume: 48, Issue:7 Topics: Antiemetics; Basal Ganglia Diseases; Child, Preschool; Diagnosis, Differential; Diazepam; Humans; Pe	1976
[Postoperative pain and nausea]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1973, Jun-30, Volume: 93, Issue:18 Topics: Adolescent; Adult; Child; Female; Humans; Male; Meperidine; Middle Aged; Nausea; Pain, Postoperative	1973
[Postoperative vomiting and pain]. Acta anaesthesiologica, 1968, Volume: 19 Topics: Chlordiazepoxide; Female; Humans; Hypnotics and Sedatives; Male; Pain; Perphenazine; Postoperative C	1968

Intervention	participants (Number)
	no vomiting	once	twice	three times	more than 3 times
IV Dexamethasone and Oral Prednisolone	25	13	7	4	1
Placebo	14	9	19	8	0

perphenazine and Complication, Postoperative