Page last updated: 2024-11-02

perphenazine and Anesthesia

perphenazine has been researched along with Anesthesia in 22 studies

Perphenazine: An antipsychotic phenothiazine derivative with actions and uses similar to those of CHLORPROMAZINE.
perphenazine : A phenothiazine derivative in which the phenothiazine tricycle carries a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at N-10.

Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.

Research Excerpts

Excerpt	Relevance	Reference
"The effects of dexamethasone and perphenazine on vomiting after tonsillectomy in children were compared in 226 healthy children aged 2-12 yr."	9.08	Prophylaxis for vomiting by children after tonsillectomy: dexamethasone versus perphenazine. ( Roberts, DJ; Splinter, W, 1997)
"The effects of dexamethasone and perphenazine on vomiting after tonsillectomy in children were compared in 226 healthy children aged 2-12 yr."	5.08	Prophylaxis for vomiting by children after tonsillectomy: dexamethasone versus perphenazine. ( Roberts, DJ; Splinter, W, 1997)

Research

Studies (22)

Timeframe	Studies, this research(%)	All Research%
pre-1990	21 (95.45)	18.7374
1990's	1 (4.55)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
HARER, WB	1
NIELSEN, RH	1
GREADY, TG	1
ESTRADA, WJ	1
HADEN, J	1
DOBKIN, AB	4
DONALDSON, H	1
PURKIN, N	1
ALBERT, CA	1
THERGAONKAR, RD	1
RAFII, A	1
HENLEY, EE	1
ALBERT, SN	1
BRAEUTIGAM, HH	1
CANNISTRA, F	1
ABRAMS, AA	1
CHATTERJEE, SS	1
JENNET, S	1
ISRAEL, JS	1
DUNDEE, JW	2
LOVE, WJ	2
MOORE, J	2
PURKIS, IE	1
ISHII, M	1
SZEREDAY, Z	1
KOVACS, L	1
KEMENY, P	1
HODOSI, J	1
SZANTO, I	1
GORDON, EM	1
NELSON, HB	1
NICHOLL, RM	1
CLARKE, RS	1
PHILLIPS, OC	1
LYONS, WB	1
CAMPBELL, C	1
FRAZIER, TM	1
MACHADO, JF	1
SILVA, JC	1
Splinter, W	1
Roberts, DJ	1
Kovalev, MI	1
Brummer, H	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Effect of Steroids on Post-tonsillectomy Morbidities[NCT02401529]			Phase 2	100 participants (Actual)	Interventional	2013-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Average Amount of Meal Per Day

adequacy of meals (inadequate, adequate) (NCT02401529)
Timeframe: 3 days

Intervention	participants (Number)
	inadequate	adequate
IV Dexamethasone and Oral Prednisolone	16	34
Placebo	27	23

Average Frequency of Meals Per Day

average frequency of meals (1 meal, 2 meals, if more specify) (NCT02401529)
Timeframe: average number of meals consumed per day for the 1st three days post-surgery

Intervention	participants (Number)
	1 meal	2 meals	3 meals
IV Dexamethasone and Oral Prednisolone	2	20	28
Placebo	1	34	15

Duration of Post-operative Nausea

Postoperative nausea duration (no nausea,1 day, 2 days, 3 days, 4 days, if more specify) (NCT02401529)
Timeframe: 7 days

Intervention	participants (Number)
	no nausea	one day	two days	three days
IV Dexamethasone and Oral Prednisolone	33	3	14	0
Placebo	21	8	15	6

Duration of Post-operative Pain

4 selections (1 day, 2 days, 3 days, if more specify) (NCT02401529)
Timeframe: number of days at which pain was experienced within the the 1st sevn days post -surgery

Intervention	participants (Number)
	one day	two days	three days
IV Dexamethasone and Oral Prednisolone	36	11	3
Placebo	23	19	8

Maximum Severity of Post-operative Pain

5 grades (pain free, low disability and low intensity, low disability and high intensity, high disability and moderate intensity, high disability and severly limiting) (NCT02401529)
Timeframe: The severest pain grade felt within a week

Intervention	participants (Number)
	Low disability and low intensity	high disability and moderate intensity	high disability and high intensity
IV Dexamethasone and Oral Prednisolone	37	13	0
Placebo	26	21	3

Occurence of Post-operative Nausea

Postoperative nausea occurence (yes, no) (NCT02401529)
Timeframe: 7 days

Intervention	participants (Number)
	yes	no
IV Dexamethasone and Oral Prednisolone	17	33
Placebo	29	21

Occurence of Postoperative Vomiting

Postoperative vomiting occurrence (yes, no) (NCT02401529)
Timeframe: 7 days

Intervention	participants (Number)
	yes	no
IV Dexamethasone and Oral Prednisolone	25	25
Placebo	36	14

Onset of 1st Post-operative Oral Intake

feeding onset (1st day i. surgery day, 2nd day, 3rd day) (NCT02401529)
Timeframe: Onset of 1st post-operative oral intake recorded within the 1st 3days post-surgery

Intervention	participants (Number)
	surgery day	1st day after surgery
IV Dexamethasone and Oral Prednisolone	46	4
Placebo	37	13

Onset of Post-operative Nausea

Postoperative nausea onset (no nausea, immediate, 1st day, 2nd day, 3rd day, 4th day, 5th day, 6th day, 7th day) (NCT02401529)
Timeframe: onset of 1st ocurence of nausea attack within the 1st week post-surgery

Intervention	participants (Number)
	no nausea	immediately	1st day	immediately and 1st day
IV Dexamethasone and Oral Prednisolone	33	10	4	3
Placebo	21	8	11	10

Total Number of Post-operative Vomiting Episodes

Postoperative vomiting number of attacks (no vomiting,1, 2, 3, if more specify) (NCT02401529)
Timeframe: total number of post-operative vomiting episodes which were experienced within the 1st week post-surgery

Intervention	participants (Number)
	no vomiting	once	twice	three times	more than 3 times
IV Dexamethasone and Oral Prednisolone	25	13	7	4	1
Placebo	14	9	19	8	0

Trials

1 trial available for perphenazine and Anesthesia

Article	Year
Prophylaxis for vomiting by children after tonsillectomy: dexamethasone versus perphenazine. Anesthesia and analgesia, 1997, Volume: 85, Issue:3 Topics: Anesthesia; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, I	1997

Other Studies

21 other studies available for perphenazine and Anesthesia

Article	Year
Tranquilizers in obstetrics and gynecology; studies with trilafon. Obstetrics and gynecology, 1958, Volume: 11, Issue:3 Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Female; Genital Diseases, Female; Gynecology; Human	1958
The use of perphenazine in ocular surgery: a preliminary report. American journal of ophthalmology, 1958, Volume: 46, Issue:3 Pt 1 Topics: Anesthesia; Eye; Humans; Ophthalmologic Surgical Procedures; Perphenazine; Phenothiazines	1958
Intramuscular perphenazine in labor; a study of 700 patients. American journal of obstetrics and gynecology, 1959, Volume: 77, Issue:2 Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Female; Humans; Labor, Obstetric; Perphenazine; Phe	1959
The effect of perphenazine on epinephrine-induced cardiac arrhythmias in dogs. II. Anaesthesia with cyclopropane, chloroform, and trichlorethylene. Canadian Anaesthetists' Society journal, 1959, Volume: 6, Issue:3 Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Animals; Arrhythmias, Cardiac; Chloroform; Cyclopro	1959
Potentiation of thiopentone anaesthesia. Comparison of promethazine, chlorpromazine, perphenazine, fluphenazine, thiopropazate, pipamazine and triflupromazine. British journal of anaesthesia, 1960, Volume: 32 Topics: Aged; Analgesia; Anesthesia; Anesthesia and Analgesia; Antiemetics; Chlorpromazine; Fluphenazine; Hi	1960
The place of perphenazine (trilafon) in anesthesia. The Medical annals of the District of Columbia, 1959, Volume: 28 Topics: Anesthesia; Anesthesiology; Perphenazine	1959
[On the use of a neuroleptic in obsterical twilight sleep]. Zentralblatt fur Gynakologie, 1959, Dec-19, Volume: 81 Topics: Anesthesia; Anesthesia, Obstetrical; Anesthesiology; Antipsychotic Agents; Obstetrics; Perphenazine	1959
Perphenazine in obstetrics; evaluation of its use to replace an analgesic. Obstetrics and gynecology, 1959, Volume: 14 Topics: Analgesics; Anesthesia; Anesthesia, Obstetrical; Obstetrics; Perphenazine; Scopolamine	1959
Perphenazine in clinical anaesthesia. Canadian Anaesthetists' Society journal, 1959, Volume: 6 Topics: Anesthesia; Anesthesiology; Perphenazine	1959
Perphenazine premedication for bronchospirometry. British journal of anaesthesia, 1961, Volume: 33 Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Anesthesiology; Bronchospirometry; Pain Management;	1961
The effect of SA 97, perphenazine, and hydroxyzine on epinephrine-induced cardiac arrhythmias during methoxyflurane anaesthesia in dogs. Canadian Anaesthetists' Society journal, 1962, Volume: 9 Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Animals; Anti-Allergic Agents; Arrhythmias, Cardiac	1962
ALTERATIONS IN RESPONSE TO SOMATIC PAIN ASSOCIATED WITH ANAESTHESIA. XV. FURTHER STUDIES WITH PHENOTHIAZINE DERIVATIVES AND SIMILAR DRUGS. British journal of anaesthesia, 1963, Volume: 35 Topics: Analgesics; Analgesics, Non-Narcotic; Anesthesia; Antiemetics; Antipyretics; Chlorpromazine; Chlorpr	1963
THE EFFECTIVENESS OF ANTI-EMETIC AGENTS: A COMPARISON OF THE ANTI-EMETIC ACTIVITY OF TRIFLUOPROMAZINE (VESPRIN), PERPHENAZINE (TRILAFON), AND TRIFLUOPERAZINE (STELAZINE) WITH THAT OF DIMENHYDRINATE (GRAVOL) IN POSTANESTHETIC VOMITING. Canadian Anaesthetists' Society journal, 1963, Volume: 10 Topics: Anesthesia; Anesthesiology; Antiemetics; Dimenhydrinate; Humans; Perphenazine; Postoperative Complic	1963
PRAEMEDICATION TO GYNAECOLOGICAL OPERATIONS. Therapia Hungarica (English edition), 1963, Volume: 11 Topics: Anesthesia; Anesthesia, Endotracheal; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthesia, L	1963
[TREATMENT OF SUSTAINED CONVULSIONS IN CHILDHOOD WITH N2O ANESTHESIA. (PRELIMINARY REPORT)]. Orvosi hetilap, 1964, Apr-12, Volume: 105 Topics: Adolescent; Anesthesia; Anesthesia, Inhalation; Bronchopneumonia; Child; Encephalitis; Enterocolitis	1964
A DOUBLE BLIND STUDY OF THE EFFECT OF TRANQUILIZERS DURING LABOR. American journal of obstetrics and gynecology, 1965, Jun-01, Volume: 92 Topics: Anesthesia; Anesthesia, Obstetrical; Biomedical Research; Double-Blind Method; Drug Therapy; Female;	1965
STUDIES OF DRUGS GIVEN BEFORE ANAESTHESIA. VI. THE PHENOTHIAZINE DERIVATIVES. British journal of anaesthesia, 1965, Volume: 37 Topics: Anesthesia; Anesthesia, General; Atropine; Chlorpromazine; Chlorprothixene; Fluphenazine; Humans; Me	1965
Trilafon analgesia during labor. Obstetrics and gynecology, 1960, Volume: 15 Topics: Anesthesia; Anesthesia, Obstetrical; Female; Humans; Labor, Obstetric; Perphenazine; Pregnancy	1960
[Perphenazine in surgery]. Anais paulistas de medicina e cirurgia, 1961, Volume: 82 Topics: Anesthesia; Anesthesiology; Perphenazine	1961
[Use of etaperazine]. Veterinariia, 1979, Issue:1 Topics: Anesthesia; Anesthetics; Animals; Castration; Cattle; Dogs; Dose-Response Relationship, Drug; Drug E	1979
[Relief of coprostasis in a leopard using Decentan-Thiogenal anesthesia]. Berliner und Munchener tierarztliche Wochenschrift, 1969, Oct-15, Volume: 82, Issue:20 Topics: Anesthesia; Anesthetics; Animals; Carnivora; Cats; Enema; Fecal Impaction; Perphenazine	1969