perphenazine has been researched along with Acute Confusional Senile Dementia in 7 studies
Perphenazine: An antipsychotic phenothiazine derivative with actions and uses similar to those of CHLORPROMAZINE.
perphenazine : A phenothiazine derivative in which the phenothiazine tricycle carries a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at N-10.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study of 45 elderly patients suffering from dementia and treated with perphenazine, 5 patients who were prospectively identified as poor P450 2D6 metabolizers had significantly greater side effects than the 40 extensive metabolizers." | 3.69 | Prospective cytochrome P450 phenotyping for neuroleptic treatment in dementia. ( Altieri, LP; Mulsant, BH; Perel, JM; Pollock, BG; Rosen, J; Sweet, RA, 1995) |
| "Alzheimer's disease is imposing a growing social and economic burden worldwide, and effective therapies are urgently required." | 1.91 | Perphenazine-Macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid. ( Adamson, JSP; Ball, SR; Jiang, X; Kassiou, M; Knowles, TPJ; Kwan, AH; Lo, V; McKenzie, ADJ; Meisl, G; Rutledge, PJ; Sanz-Hernandez, M; Sullivan, MA; Sunde, M; Todd, MH; Werry, EL; Zimmermann, MR, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Necula, M | 1 |
| Kayed, R | 1 |
| Milton, S | 1 |
| Glabe, CG | 1 |
| Ball, SR | 1 |
| Adamson, JSP | 1 |
| Sullivan, MA | 1 |
| Zimmermann, MR | 1 |
| Lo, V | 1 |
| Sanz-Hernandez, M | 1 |
| Jiang, X | 1 |
| Kwan, AH | 1 |
| McKenzie, ADJ | 1 |
| Werry, EL | 1 |
| Knowles, TPJ | 1 |
| Kassiou, M | 1 |
| Meisl, G | 1 |
| Todd, MH | 1 |
| Rutledge, PJ | 1 |
| Sunde, M | 1 |
| Zhu, L | 1 |
| Song, Y | 1 |
| Cheng, PN | 1 |
| Moore, JS | 1 |
| Pollock, BG | 2 |
| Mulsant, BH | 2 |
| Sweet, RA | 2 |
| Rosen, J | 2 |
| Altieri, LP | 1 |
| Perel, JM | 1 |
| Lo, KH | 1 |
| Yao, JK | 1 |
| Henteleff, RA | 1 |
| Mazumdar, S | 1 |
| Levkovitz, Y | 1 |
| Bloch, Y | 1 |
| Kaplan, D | 1 |
| Diskin, A | 1 |
| Abramovitchi, I | 1 |
| Baumann, P | 1 |
| Eap, CB | 1 |
| Zullino, DF | 1 |
2 trials available for perphenazine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Association of plasma homovanillic acid with behavioral symptoms in patients diagnosed with dementia: a preliminary report.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antipsychotic Agents; Behavior; Dyskinesia, Drug-Induced | 1997 |
Fluvoxamine for psychosis in Alzheimer's disease.
Topics: Acute Disease; Aged; Alzheimer Disease; Ambulatory Care; Antipsychotic Agents; Brief Psychiatric Rat | 2001 |
5 other studies available for perphenazine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Humans; Plaque, Amyloid; Protein Structu | 2007 |
Perphenazine-Macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Amyloidogenic Proteins; Humans; Peptide Fragments | 2023 |
Molecular Design for Dual Modulation Effect of Amyloid Protein Aggregation.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Circular Dichroism; Drug Des | 2015 |
Prospective cytochrome P450 phenotyping for neuroleptic treatment in dementia.
Topics: Aged; Alzheimer Disease; Cytochrome P-450 Enzyme System; Dementia; Female; Humans; Male; Middle Aged | 1995 |
Fluvoxamine and perphenazine for psychosis in Alzheimer's disease: pharmacokinetic considerations.
Topics: Aged; Alzheimer Disease; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Interactio | 2001 |