Page last updated: 2024-09-03

peroxynitrous acid and Acute Liver Injury, Drug-Induced

peroxynitrous acid has been researched along with Acute Liver Injury, Drug-Induced in 38 studies

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (7.89)29.6817
2010's14 (36.84)24.3611
2020's21 (55.26)2.80

Authors

AuthorsStudies
Cheng, D; Gong, X; He, L; Li, W; Peng, R; Shen, Y; Shi, L; Yuan, L1
Chen, D; Fan, Y; Gao, J; Li, A; Li, L; Lin, H; Liu, X1
Chau, JHC; Kwok, RTK; Lam, JWY; Lam, KWK; Lee, MMS; Tang, BZ; Yu, EY; Zhang, R1
Jiang, M; Li, Y; Ma, X; Ma, Z; Peng, C; Wen, L; Yang, J; Yu, H1
Adelusi, OB; Jaeschke, H; Lemasters, JJ; Ramachandran, A1
Gao, MJ; Guo, JS; Kang, YF; Meng, YL; Wang, YH; Wei, R; Xu, JQ1
Gao, MJ; Guo, XH; Kang, YF; Liang, ZS; Sun, JX; Wang, BD; Wang, YH; Wei, R; Xu, JQ; Zhang, CF; Zhou, JT1
Feng, Y; Huang, Y; Jing, C; Liu, W; Liu, Y; Song, X; Wang, Y; Zhang, G1
Chai, X; Chen, C; Han, HH; He, XP; Li, B; Sun, L; Sun, S; Yang, J; Zhang, J; Zhang, W; Zhang, Y1
Lu, X; Wang, H; Wang, J; Wang, N; Zhang, B; Zhang, J; Zhao, W1
Cao, Q; Liang, T; Niu, L; Wang, J; Zhang, T; Zhang, Y1
Pan, Y; Xu, H; Yang, Q; Yuan, Z1
Chen, S; Fu, S; Hou, P; Li, H; Li, Q; Li, S; Liu, X; Liu, Y; Ma, Y; Zhang, H1
Fei, J; Jiang, WL; Li, CY; Li, Y; Wang, WX; Zhao, YT1
Chen, Z; Jiang, J; Liu, S; Meng, X; Tao, P; Zhao, M; Zhao, Q; Zou, L1
Chen, Y; Han, X; Li, B; Wei, P; Yi, T; Yuan, W; Zhang, M; Zhao, M; Zhuang, H1
Cheng, D; Gong, X; Lv, Y; Wu, Q; Yuan, J; Yuan, L; Zhang, X1
Liu, Z; Mao, Z; Wang, Z; Xiong, J; Zhang, F1
Dong, WP; Gao, GQ; Li, Y; Mao, GJ; Su, L; Wang, QQ; Wang, YY; Zhang, G1
Deng, Y; Feng, G1
Jiang, WL; Li, CY; Li, Y; She, ZP; Tian, Y; Zhou, DY1
Cheng, D; Gong, X; Xu, W; Yuan, L; Zhang, XB1
Barnhill, MS; Lewis, JH; Real, M1
Alhoshan, MS; El-Toni, AM; Fan, Y; Lei, Z; Li, D; Sun, C; Wang, S; Zhang, F1
Fan, N; Li, P; Liu, X; Ma, C; Tang, B; Wang, X; Wu, L; Zhang, W; Zhou, Y1
Cui, M; Gu, Y; Li, L; Tong, Y; Wang, P; Xia, L1
Alder, NN; Boelsterli, UA; Chamberland, SR; Imaizumi, N; Lee, KK1
Anraku, M; Hirayama, F; Iohara, D; Irie, T; Ishitsuka, Y; Uekama, K; Umezaki, Y1
Bajt, ML; Du, K; Jaeschke, H; McGill, MR; Xie, Y1
Jaeschke, H; Saito, C; Zwingmann, C1
Hsu, DZ; Li, YH; Liu, MY; Srinivasan, P; Su, SB1
Baines, CP; Jaeschke, H; Lebofsky, M; Lemasters, JJ; Ramachandran, A1
Bajt, ML; Farhood, A; Jaeschke, H; Lebofsky, M; Lemasters, JJ; Ramachandran, A; Yan, HM1
Boelsterli, UA; LoGuidice, A1
Jaeschke, H; McGill, MR; Ramachandran, A1
Farhood, A; Ho, YS; Jaeschke, H; Knight, TR1
Bajt, ML; Cover, C; Jaeschke, H; Knight, TR; Lemasters, JJ; Mansouri, A; Pessayre, D1
Bajt, ML; Farhood, A; Jaeschke, H; Lemasters, JJ1

Reviews

2 review(s) available for peroxynitrous acid and Acute Liver Injury, Drug-Induced

ArticleYear
Latest advances in diagnosing and predicting DILI: what was new in 2017?
    Expert review of gastroenterology & hepatology, 2018, Volume: 12, Issue:10

    Topics: Algorithms; Biomarkers; Chemical and Drug Induced Liver Injury; Computer Simulation; HLA Antigens; Humans; MicroRNAs; Optical Imaging; Peroxynitrous Acid; Prognosis; Risk Factors

2018
Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity.
    Drug metabolism reviews, 2012, Volume: 44, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antioxidants; Apoptosis; Cell Death; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Humans; Inflammation; Liver; Mitochondria; Necrosis; Oxidants; Oxidative Stress; Peroxynitrous Acid; Reactive Oxygen Species

2012

Other Studies

36 other study(ies) available for peroxynitrous acid and Acute Liver Injury, Drug-Induced

ArticleYear
A highly selective ratiometric molecular probe for imaging peroxynitrite during drug-induced acute liver injury.
    Journal of materials chemistry. B, 2021, 10-13, Volume: 9, Issue:39

    Topics: Animals; Chemical and Drug Induced Liver Injury; Fluorescent Dyes; Hepatocytes; Humans; Mice; Mitochondria; Peroxynitrous Acid; RAW 264.7 Cells

2021
Deep-tissue real-time imaging of drug-induced liver injury with peroxynitrite-responsive
    Chemical communications (Cambridge, England), 2021, Sep-21, Volume: 57, Issue:75

    Topics: Animals; Cell Line; Chemical and Drug Induced Liver Injury; Fluorine-19 Magnetic Resonance Imaging; Lipopolysaccharides; Mice; Peroxynitrous Acid; Time Factors

2021
A ratiometric theranostic system for visualization of ONOO
    Biomaterials science, 2022, Feb-15, Volume: 10, Issue:4

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Liver; Mice; Mice, Inbred C57BL; Peroxynitrous Acid; Pharmaceutical Preparations; Precision Medicine

2022
A New Ratiometric Design Strategy Based on Modulation of π-Conjugation Unit for Developing Fluorescent Probe and Imaging of Cellular Peroxynitrite.
    Analytical chemistry, 2022, 03-22, Volume: 94, Issue:11

    Topics: Chemical and Drug Induced Liver Injury; Fluorescent Dyes; Humans; Mitochondria; Optical Imaging; Peroxynitrous Acid

2022
The role of Iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice.
    Toxicology and applied pharmacology, 2022, 06-15, Volume: 445

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Deferoxamine; Hepatocytes; Iron; Lipid Peroxidation; Liver; Male; Mice; Mice, Inbred C57BL; Minocycline; Mitochondria, Liver; Oxidative Stress; Peroxynitrous Acid

2022
A highly selective probe for ratiometric imaging peroxynitrite in living cells and in vivo.
    Bioorganic chemistry, 2022, Volume: 128

    Topics: Chemical and Drug Induced Liver Injury; Fluorescent Dyes; Humans; Optical Imaging; Peroxynitrous Acid

2022
Development of peroxynitrite-responsive fluorescence probe for recognition of drug-induced liver injury.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2022, Dec-15, Volume: 283

    Topics: Animals; Chemical and Drug Induced Liver Injury; Fluorescence; Fluorescent Dyes; Peroxynitrous Acid; Zebrafish

2022
Dual-targetable fluorescent probe for mapping the fluctuation of peroxynitrite in drug-induced liver injury model.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2023, Feb-05, Volume: 286

    Topics: Chemical and Drug Induced Liver Injury; Fluorescence; Fluorescent Dyes; Humans; Peroxynitrous Acid

2023
A Highly Sensitive and Selective Near-Infrared Fluorescent Probe for Imaging Peroxynitrite in Living Cells and Drug-Induced Liver Injury Mice.
    Analytical chemistry, 2023, 04-04, Volume: 95, Issue:13

    Topics: Animals; Biphenyl Compounds; Chemical and Drug Induced Liver Injury; Fluorescent Dyes; Mice; Optical Imaging; Peroxynitrous Acid

2023
Quasi-LD-Targeted and ONOO
    Analytical chemistry, 2023, 04-11, Volume: 95, Issue:14

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Fluorescent Dyes; Humans; Lipid Droplets; Mice; Non-alcoholic Fatty Liver Disease; Peroxynitrous Acid

2023
Simultaneous detection of mitochondrial viscosity and peroxynitrite in livers from subjects with drug-induced fatty liver disease using a novel fluorescent probe.
    Talanta, 2023, Aug-01, Volume: 260

    Topics: Animals; Chemical and Drug Induced Liver Injury; Fluorescent Dyes; Mice; Mitochondria; Peroxynitrous Acid; Viscosity

2023
Screening and optimization of a water-soluble near-infrared fluorescent probe for drug-induced liver injury monitoring.
    Analytica chimica acta, 2023, Oct-02, Volume: 1276

    Topics: Animals; Chemical and Drug Induced Liver Injury; Fluorescent Dyes; Optical Imaging; Peroxynitrous Acid; Zebrafish

2023
Near-infrared molecular sensor for visualizing and tracking ONOO
    Analytical and bioanalytical chemistry, 2023, Volume: 415, Issue:29-30

    Topics: Animals; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Fluorescent Dyes; HeLa Cells; Humans; Isoniazid; Mice; Peroxynitrous Acid; Pyrazinamide; Zebrafish

2023
A hepatocyte-targeting near-infrared ratiometric fluorescent probe for monitoring peroxynitrite during drug-induced hepatotoxicity and its remediation.
    Chemical communications (Cambridge, England), 2019, Nov-26, Volume: 55, Issue:95

    Topics: Acetaminophen; Animals; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Fluorescent Dyes; Hepatocytes; Humans; Infrared Rays; Mice; Mice, Inbred BALB C; Molecular Structure; Optical Imaging; Peroxynitrous Acid

2019
A Dual-Emissive Phosphorescent Polymeric Probe for Exploring Drug-Induced Liver Injury via Imaging of Peroxynitrite Elevation In Vivo.
    ACS applied materials & interfaces, 2020, Mar-18, Volume: 12, Issue:11

    Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Iridium; Liver; Luminescent Agents; Mice; Mice, Nude; Optical Imaging; Peroxynitrous Acid; Polymers

2020
Real-time monitoring and accurate diagnosis of drug-induced hepatotoxicity in vivo by ratio-fluorescence and photoacoustic imaging of peroxynitrite.
    Nanoscale, 2020, May-14, Volume: 12, Issue:18

    Topics: Acetaminophen; Animals; Carbocyanines; Chemical and Drug Induced Liver Injury; Female; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Infrared Rays; Liver; Metal Nanoparticles; Mice; Mice, Inbred BALB C; Peroxynitrous Acid; Photoacoustic Techniques; Up-Regulation

2020
High-Selectivity Fluorescent Reporter toward Peroxynitrite in a Coexisting Nonalcoholic Fatty Liver and Drug-Induced Liver Diseases Model.
    Analytical chemistry, 2020, 08-18, Volume: 92, Issue:16

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Coumarins; Cytochrome P-450 CYP2E1; Diet, High-Fat; Fatty Acids; Fluorescent Dyes; Hep G2 Cells; Humans; Limit of Detection; Liver; Mice; Microscopy, Fluorescence; Mitochondria; Non-alcoholic Fatty Liver Disease; Peroxynitrous Acid

2020
Investigations of drug-induced liver injury by a peroxynitrite activatable two-photon fluorescence probe.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2021, Feb-05, Volume: 246

    Topics: Animals; Chemical and Drug Induced Liver Injury; Fluorescence; Fluorescent Dyes; Humans; Mice; Peroxynitrous Acid; Photons

2021
A two-photon excited near-infrared fluorescent probe for imaging peroxynitrite during drug-induced hepatotoxicity and its remediation.
    Talanta, 2021, Jan-01, Volume: 221

    Topics: Animals; Chemical and Drug Induced Liver Injury; Fluorescent Dyes; Mice; Peroxynitrous Acid; Pharmaceutical Preparations; Photons

2021
Visualization of ONOO
    Analytical chemistry, 2020, 11-03, Volume: 92, Issue:21

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Electron Transport; Fluorescent Dyes; HeLa Cells; Humans; Liver; Mice; Optical Imaging; Peroxynitrous Acid; Signal-To-Noise Ratio; Viscosity

2020
Novel near-infrared fluorescence probe with large Stokes shift for monitoring CCl
    Talanta, 2021, Feb-01, Volume: 223, Issue:Pt 1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Fluorescent Dyes; Mice; Optical Imaging; Peroxynitrous Acid

2021
Design Strategy of Fluorescent Probes for Live Drug-Induced Acute Liver Injury Imaging.
    Accounts of chemical research, 2021, 01-19, Volume: 54, Issue:2

    Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Design; Fluorescent Dyes; Hep G2 Cells; Humans; Hydrogen Sulfide; Mice; Microscopy, Fluorescence; Monoamine Oxidase; Nanoparticles; Optical Imaging; Peroxynitrous Acid; Reactive Nitrogen Species; Reactive Oxygen Species; Spectroscopy, Near-Infrared

2021
Peroxynitrite Activatable NIR-II Fluorescent Molecular Probe for Drug-Induced Hepatotoxicity Monitoring.
    Analytical chemistry, 2019, 04-02, Volume: 91, Issue:7

    Topics: Acetaminophen; Animals; Biosensing Techniques; Cell Line, Tumor; Cell Survival; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Fluorescence; Fluorescent Dyes; Humans; Infrared Rays; Mice; Mice, Nude; Peroxynitrous Acid

2019
In situ visualization of peroxisomal peroxynitrite in the livers of mice with acute liver injury induced by carbon tetrachloride using a new two-photon fluorescent probe.
    Chemical communications (Cambridge, England), 2019, Jun-06, Volume: 55, Issue:47

    Topics: Amino Acid Sequence; Animals; Carbon Tetrachloride; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Fluorescent Dyes; Humans; Liver; Mice; Microscopy, Fluorescence, Multiphoton; Peroxisomes; Peroxynitrous Acid

2019
A selective fluorescent turn-on probe for imaging peroxynitrite in living cells and drug-damaged liver tissues.
    Talanta, 2019, Nov-01, Volume: 204

    Topics: Animals; Benzothiazoles; Boronic Acids; Chemical and Drug Induced Liver Injury; Coumarins; Fluorescence; Fluorescent Dyes; Hep G2 Cells; Humans; Limit of Detection; Liver; Male; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Peroxynitrous Acid

2019
Targeting mitochondria with methylene blue protects mice against acetaminophen-induced liver injury.
    Hepatology (Baltimore, Md.), 2015, Volume: 61, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Cell Death; Cells, Cultured; Chemical and Drug Induced Liver Injury; Drug Evaluation, Preclinical; Electron Transport Complex II; Enzyme Inhibitors; Hepatocytes; Imines; Liver; Male; Methylene Blue; Mice, Inbred C57BL; Mitochondria, Liver; Necrosis; Peroxynitrous Acid; Succinate Dehydrogenase

2015
Preparation of hydrophilic C60(OH)10/2-hydroxypropyl-β-cyclodextrin nanoparticles for the treatment of a liver injury induced by an overdose of acetaminophen.
    Biomaterials, 2015, Volume: 45

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Acetaminophen; Animals; Antioxidants; Benzothiazoles; beta-Cyclodextrins; Biphenyl Compounds; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Overdose; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Fullerenes; Glutathione; Hydrophobic and Hydrophilic Interactions; Hydroxylation; Liver; Male; Mice, Inbred C57BL; Nanoparticles; Nitric Oxide; Oxidative Stress; Particle Size; Peroxynitrous Acid; Picrates; Protective Agents; Solubility; Static Electricity; Sulfonic Acids; Tyrosine

2015
Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2015, Volume: 81

    Topics: Acetaminophen; Animals; Apoptosis Inducing Factor; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Drug Overdose; Endonucleases; Hepatocytes; JNK Mitogen-Activated Protein Kinases; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria; Oxidative Stress; Peroxynitrous Acid; Protein Binding; Resveratrol; Stilbenes; Tyrosine

2015
Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine.
    Hepatology (Baltimore, Md.), 2010, Volume: 51, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Drug Overdose; Energy Metabolism; Glutathione; Male; Mice; Mice, Inbred C3H; Mitochondria, Liver; Peroxynitrous Acid; Reactive Oxygen Species; Up-Regulation

2010
Ostensibly ineffectual doses of cadmium and lipopolysaccharide causes liver damage in rats.
    Human & experimental toxicology, 2011, Volume: 30, Issue:7

    Topics: Animals; Cadmium Chloride; Chemical and Drug Induced Liver Injury; Drug Synergism; Glutathione Peroxidase; Interleukin-1beta; Lipid Peroxidation; Lipopolysaccharides; Liver; Liver Function Tests; Male; Metallothionein; Nitrites; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Wistar; Specific Pathogen-Free Organisms

2011
Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury.
    Free radical research, 2011, Volume: 45, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cyclophilins; Cytochrome P-450 Enzyme System; DNA Fragmentation; Glutathione; Humans; Immunohistochemistry; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Liver; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Necrosis; Oxidative Stress; Peptidyl-Prolyl Isomerase F; Peroxynitrous Acid

2011
Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity.
    Toxicological sciences : an official journal of the Society of Toxicology, 2011, Volume: 122, Issue:2

    Topics: Acetaminophen; Animals; Apoptosis Inducing Factor; Blotting, Western; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Drug Overdose; Glutathione Disulfide; Hepatocytes; Immunohistochemistry; In Situ Nick-End Labeling; Liver; Male; Mice; Mitochondria, Liver; Necrosis; Oxidative Stress; Peroxynitrous Acid; Reactive Oxygen Species

2011
Acetaminophen overdose-induced liver injury in mice is mediated by peroxynitrite independently of the cyclophilin D-regulated permeability transition.
    Hepatology (Baltimore, Md.), 2011, Sep-02, Volume: 54, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cyclophilins; Drug Overdose; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Peptidyl-Prolyl Isomerase F; Peroxynitrous Acid; Porphyrins

2011
Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Glutathione; Immunohistochemistry; Injections, Intravenous; Liver; Male; Mice; Mice, Inbred C3H; Mitochondria, Liver; Necrosis; Peroxynitrous Acid; Serum Albumin, Bovine; Tyrosine

2002
Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 315, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Cell Nucleus; Chemical and Drug Induced Liver Injury; DNA Damage; DNA Fragmentation; DNA, Mitochondrial; Endonucleases; In Situ Hybridization; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C3H; Mitochondria, Liver; Peroxynitrous Acid; Subcellular Fractions; Tumor Necrosis Factor-alpha

2005
Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity.
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 324, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; bcl-2-Associated X Protein; Chemical and Drug Induced Liver Injury; Disease Models, Animal; DNA Fragmentation; Liver Diseases; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Liver; Necrosis; Peroxynitrous Acid

2008