Page last updated: 2024-09-03

perospirone and Schizophrenia

perospirone has been researched along with Schizophrenia in 38 studies

*Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior. [MeSH]

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.63)18.7374
1990's0 (0.00)18.2507
2000's21 (55.26)29.6817
2010's15 (39.47)24.3611
2020's1 (2.63)2.80

Authors

AuthorsStudies
Chau-Wong, M; Seeman, P; Tedesco, J; Wong, K1
Chen, Y; Cui, X; Ding, J; Gong, Y; Hu, J; Meng, Z; Tian, M; Wei, B; Yang, L1
Higuchi, Y; Ito, T; Sumiyoshi, T; Suzuki, M1
Suzuki, M; Takahashi, S; Uchiyama, M1
Iwata, N; Kishi, T1
Iwata, N; Kishi, T; Matsuda, Y1
Fabbri, C; Kato, M; Kinoshita, T; Koshikawa, Y; Nonen, S; Okugawa, G; Sakai, S; Serretti, A; Sunada, N; Takekita, Y; Wakeno, M3
Arai, H; Higuchi, Y; Itoh, T; Kawasaki, Y; Kurachi, M; Matsui, M; Sumiyoshi, C; Sumiyoshi, T; Suzuki, M1
Kato, M; Kinoshita, T; Kishimoto, T; Koh, J; Matsumoto, N; Morikawa, M; Okugawa, G; Shinosaki, K; Wakeno, M; Yoneda, H1
Arakawa, R; Ito, H; Okubo, Y; Okumura, M; Suhara, T; Takahashi, H; Takano, A; Takano, H1
Fukui, N; Inoue, Y; Ono, S; Sawamura, K; Someya, T; Sugai, T; Suzuki, Y; Tsuneyama, N; Watanabe, J1
Fujii, A; Furukori, H; Inoue, Y; Kaneko, S; Sugawara, N; Tsuchimine, S; Yasui-Furukori, N1
Hori, H; Nakamura, J; Okamoto, T; Umene-Nakano, W; Yoshimura, R1
Gen, K; Inoue, Y; Suzuki, H1
Fukui, N; Ono, S; Saito, M; Someya, T; Sugai, T; Suzuki, Y; Tsuneyama, N; Watanabe, J1
Fujiki, R; Matsuoka, T; Mori, K; Morita, K; Shoji, Y; Uchimura, N1
Kato, M; Kinoshita, T; Nishida, K; Okugawa, G; Sakai, S; Suwa, A; Takekita, Y; Wakeno, M1
Iseki, E; Kase, A; Katsuse, O; Kosaka, K; Oyama, I; Shoji, M; Togo, T; Uchikado, H1
Nishikawa, T; Takeuchi, T1
Honma, H; Iwasaki, S; Kondo, C; Masui, T; Matsubara, S; Osawa, T1
Kawai, M; Minabe, Y; Mori, N; Takei, N; Tani, K; Yokoshima, T1
Nakamura, M; Nishida, M1
Furukori, H; Inoue, Y; Kaneko, S; Nakagami, T; Saito, M; Tateishi, T; Yasui-Furukori, N1
Mori, K; Morinobu, S; Nagao, M; Okamoto, Y; Yamashita, H; Yamawaki, S2
Abekawa, T; Kitaichi, Y; Koyama, T; Matsuyama, T1
Araki, T; Iwanami, A; Kasai, K; Kato, N; Kuwabara, H; Suga, M; Sumiyoshi, T; Yamasue, H1
Araki, T; Iwanami, A; Kasai, K; Kato, N; Rogers, MA1
Asai, K; Shimada, Y; Tanaka, Y; Ueda, H; Yoshida, S1
Hamanaka, S; Kamijo, Y1
Ishii, E; Ishimatsu, S; Kizu, J; Otani, N; Tsuchiya, M1
Arai, H; Higuchi, Y; Kurachi, M; Matsui, M; Meltzer, HY; Sumiyoshi, T; Takamiya, C1
Koyama, T; Kusumi, I; Masui, T1
Ohno, Y1
McClellan, K; Onrust, SV1
de Paulis, T1

Reviews

6 review(s) available for perospirone and Schizophrenia

ArticleYear
Efficacy and tolerability of perospirone in schizophrenia: a systematic review and meta-analysis of randomized controlled trials.
    CNS drugs, 2013, Volume: 27, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Female; Humans; Isoindoles; Male; Middle Aged; Randomized Controlled Trials as Topic; Schizophrenia; Thiazoles; Young Adult

2013
Cardiometabolic risks of blonanserin and perospirone in the management of schizophrenia: a systematic review and meta-analysis of randomized controlled trials.
    PloS one, 2014, Volume: 9, Issue:2

    Topics: Adult; Antipsychotic Agents; Blood Glucose; Double-Blind Method; Glycated Hemoglobin; Heart; Humans; Isoindoles; Piperazines; Piperidines; Randomized Controlled Trials as Topic; Risk; Schizophrenia; Thiazoles; Weight Gain

2014
[An introduction to antipsychotics].
    Ryoikibetsu shokogun shirizu, 2003, Issue:38

    Topics: Antipsychotic Agents; Benzodiazepines; Dibenzothiazepines; Dopamine Antagonists; Humans; Indoles; Isoindoles; Olanzapine; Pirenzepine; Quetiapine Fumarate; Receptors, Dopamine; Receptors, Serotonin; Risperidone; Schizophrenia; Serotonin Antagonists; Thiazoles

2003
[Pharmacological characteristics of perospirone hydrochloride, a novel antipsychotic agent].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2000, Volume: 116, Issue:4

    Topics: Animals; Antipsychotic Agents; Basal Ganglia Diseases; Clinical Trials as Topic; Humans; Indoles; Isoindoles; Schizophrenia; Serotonin Antagonists; Thiazoles

2000
Perospirone.
    CNS drugs, 2001, Volume: 15, Issue:4

    Topics: Animals; Antipsychotic Agents; Clinical Trials as Topic; Humans; Indoles; Isoindoles; Psychiatric Status Rating Scales; Schizophrenia; Thiazoles; Treatment Outcome

2001
Perospirone (Sumitomo Pharmaceuticals).
    Current opinion in investigational drugs (London, England : 2000), 2002, Volume: 3, Issue:1

    Topics: Animals; Clinical Trials as Topic; Dopamine Antagonists; Humans; Indoles; Isoindoles; Schizophrenia; Serotonin Antagonists; Technology, Pharmaceutical; Thiazoles

2002

Trials

13 trial(s) available for perospirone and Schizophrenia

ArticleYear
HTR1A Gene Polymorphisms and 5-HT1A Receptor Partial Agonist Antipsychotics Efficacy in Schizophrenia.
    Journal of clinical psychopharmacology, 2015, Volume: 35, Issue:3

    Topics: Adult; Antipsychotic Agents; Aripiprazole; Female; Haplotypes; Humans; Isoindoles; Male; Middle Aged; Polymorphism, Single Nucleotide; Receptor, Serotonin, 5-HT1A; Schizophrenia; Serotonin 5-HT1 Receptor Agonists; Thiazoles; Treatment Outcome

2015
Antagonist and partial agonist at the dopamine D2 receptors in drug-naïve and non-drug-naïve schizophrenia: a randomized, controlled trial.
    European archives of psychiatry and clinical neuroscience, 2015, Volume: 265, Issue:7

    Topics: Adult; Aged; Akathisia, Drug-Induced; Antipsychotic Agents; Aripiprazole; Basal Ganglia Diseases; Dopamine Agonists; Dopamine D2 Receptor Antagonists; Drug Partial Agonism; Female; Humans; Isoindoles; Male; Middle Aged; Receptors, Dopamine D2; Schizophrenia; Schizophrenic Psychology; Thiazoles; Treatment Outcome; Young Adult

2015
Serotonin 7 Receptor Variants Are Not Associated with Response to Second-Generation Antipsychotics in Japanese Schizophrenia Patients.
    Neuropsychobiology, 2015, Volume: 72, Issue:2

    Topics: Adult; Antipsychotic Agents; Aripiprazole; Asian People; Female; Humans; Isoindoles; Japan; Linkage Disequilibrium; Male; Middle Aged; Polymorphism, Single Nucleotide; Precision Medicine; Psychiatric Status Rating Scales; Receptors, Serotonin; Schizophrenia; Thiazoles; Treatment Outcome

2015
Effect of perospirone on P300 electrophysiological activity and social cognition in schizophrenia: a three-dimensional analysis with sloreta.
    Psychiatry research, 2009, Jun-30, Volume: 172, Issue:3

    Topics: Adult; Antipsychotic Agents; Brain Mapping; Cognition; Event-Related Potentials, P300; Female; Frontal Lobe; Functional Laterality; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Isoindoles; Magnetoencephalography; Male; Memory; Middle Aged; Neuropsychological Tests; Outpatients; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Social Perception; Thiazoles; Verbal Learning; Young Adult

2009
Randomized clinical comparison of perospirone and risperidone in patients with schizophrenia: Kansai Psychiatric Multicenter Study.
    Psychiatry and clinical neurosciences, 2009, Volume: 63, Issue:3

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Basal Ganglia Diseases; Female; Humans; Isoindoles; Male; Middle Aged; Psychiatric Status Rating Scales; Risperidone; Schizophrenia; Schizophrenic Psychology; Thiazoles

2009
An unblinded comparison of the clinical and cognitive effects of switching from first-generation antipsychotics to aripiprazole, perospirone or olanzapine in patients with chronic schizophrenia.
    Progress in neuro-psychopharmacology & biological psychiatry, 2011, Jan-15, Volume: 35, Issue:1

    Topics: Adult; Aged; Antipsychotic Agents; Aripiprazole; Attention; Benzodiazepines; Chronic Disease; Cognition Disorders; Dose-Response Relationship, Drug; Drug Substitution; Executive Function; Female; Humans; Isoindoles; Longitudinal Studies; Male; Memory; Middle Aged; Neuropsychological Tests; Olanzapine; Piperazines; Psychiatric Status Rating Scales; Quinolones; Schizophrenia; Single-Blind Method; Thiazoles; Time Factors; Verbal Learning

2011
A 12-week randomized, open-label study of perospirone versus aripiprazole in the treatment of Japanese schizophrenia patients.
    Progress in neuro-psychopharmacology & biological psychiatry, 2013, Jan-10, Volume: 40

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Aripiprazole; Female; Humans; Isoindoles; Japan; Male; Middle Aged; Piperazines; Quinolones; Schizophrenia; Severity of Illness Index; Thiazoles; Treatment Outcome

2013
Prolactin levels in schizophrenic patients receiving perospirone in comparison to risperidone.
    Journal of pharmacological sciences, 2003, Volume: 91, Issue:3

    Topics: Antipsychotic Agents; Dose-Response Relationship, Drug; Female; Humans; Indoles; Isoindoles; Male; Middle Aged; Prolactin; Risperidone; Schizophrenia; Thiazoles

2003
Steady-state pharmacokinetics of a new antipsychotic agent perospirone and its active metabolite, and its relationship with prolactin response.
    Therapeutic drug monitoring, 2004, Volume: 26, Issue:4

    Topics: Adult; Aged; Antipsychotic Agents; Area Under Curve; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Humans; Immunoenzyme Techniques; Indoles; Isoindoles; Male; Middle Aged; Prolactin; Schizophrenia; Thiazoles; Time Factors

2004
Effects of changing from typical to atypical antipsychotic drugs on subjective sleep quality in patients with schizophrenia in a Japanese population.
    The Journal of clinical psychiatry, 2004, Volume: 65, Issue:11

    Topics: Adult; Aged; Antipsychotic Agents; Benzodiazepines; Dibenzothiazepines; Drug Administration Schedule; Female; Health Status; Hospitalization; Humans; Indoles; Isoindoles; Japan; Male; Middle Aged; Olanzapine; Psychiatric Status Rating Scales; Quetiapine Fumarate; Regression Analysis; Risperidone; Schizophrenia; Schizophrenic Psychology; Severity of Illness Index; Sleep; Thiazoles

2004
Influence of aging on the improvement of subjective sleep quality by atypical antipsychotic drugs in patients with schizophrenia: comparison of middle-aged and older adults.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2005, Volume: 13, Issue:5

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antipsychotic Agents; Benzodiazepines; Dibenzothiazepines; Female; Humans; Indoles; Isoindoles; Male; Middle Aged; Olanzapine; Polysomnography; Psychiatric Status Rating Scales; Quetiapine Fumarate; Risperidone; Schizophrenia; Schizophrenic Psychology; Sleep Initiation and Maintenance Disorders; Sleep Stages; Thiazoles

2005
Perospirone in the treatment of schizophrenia: effect on verbal memory organization.
    Progress in neuro-psychopharmacology & biological psychiatry, 2006, Volume: 30, Issue:2

    Topics: Adult; Aged; Antipsychotic Agents; Female; Humans; Indoles; Isoindoles; Male; Memory; Middle Aged; Neuropsychological Tests; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Statistics, Nonparametric; Thiazoles; Verbal Learning

2006
The effect of perospirone on auditory P300 in schizophrenia: a preliminary study.
    Progress in neuro-psychopharmacology & biological psychiatry, 2006, Aug-30, Volume: 30, Issue:6

    Topics: Adult; Antipsychotic Agents; Cognition Disorders; Data Interpretation, Statistical; Electrophysiology; Event-Related Potentials, P300; Evoked Potentials, Auditory; Female; Humans; Indoles; Isoindoles; Male; Middle Aged; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Thiazoles

2006

Other Studies

19 other study(ies) available for perospirone and Schizophrenia

ArticleYear
Brain receptors for antipsychotic drugs and dopamine: direct binding assays.
    Proceedings of the National Academy of Sciences of the United States of America, 1975, Volume: 72, Issue:11

    Topics: Animals; Binding Sites; Corpus Striatum; Dopamine; Haloperidol; Humans; Male; Rats; Receptors, Drug; Schizophrenia; Synaptosomes; Tranquilizing Agents

1975
Therapeutic drug monitoring of perospirone: The lowest effective plasma concentration in patients with schizophrenia.
    Asian journal of psychiatry, 2023, Volume: 90

    Topics: Antipsychotic Agents; Drug Monitoring; Female; Humans; Indoles; Male; Retrospective Studies; Schizophrenia

2023
Perospirone normalized P300 and cognitive function in a case of early psychosis.
    Journal of clinical psychopharmacology, 2013, Volume: 33, Issue:2

    Topics: Adolescent; Antipsychotic Agents; Cognition Disorders; Event-Related Potentials, P300; Humans; Isoindoles; Male; Schizophrenia; Thiazoles; Treatment Outcome

2013
A case of schizophrenia with meige syndrome induced by perospirone successfully treated with biperiden.
    The Journal of neuropsychiatry and clinical neurosciences, 2013,Winter, Volume: 25, Issue:1

    Topics: Adult; Antiparkinson Agents; Antipsychotic Agents; Biperiden; Female; Humans; Isoindoles; Lymphedema; Schizophrenia; Thiazoles

2013
Dopamine D2 receptor occupancy by perospirone: a positron emission tomography study in patients with schizophrenia and healthy subjects.
    Psychopharmacology, 2010, Volume: 209, Issue:4

    Topics: Adult; Antipsychotic Agents; Binding, Competitive; Brain; Case-Control Studies; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Female; Humans; Isoindoles; Magnetic Resonance Imaging; Male; Positron-Emission Tomography; Raclopride; Receptors, Dopamine D2; Schizophrenia; Thiazoles; Time Factors

2010
The wide variability of perospirone metabolism and the effect of perospirone on prolactin in psychiatric patients.
    Progress in neuro-psychopharmacology & biological psychiatry, 2010, Aug-16, Volume: 34, Issue:6

    Topics: Adult; Aged; Antipsychotic Agents; Chromatography, High Pressure Liquid; Female; Humans; Immunoenzyme Techniques; Individuality; Indoles; Isoindoles; Male; Middle Aged; Prolactin; Schizophrenia; Thiazoles

2010
Prolactin fluctuation over the course of a day during treatments with three atypical antipsychotics in schizophrenic patients.
    Human psychopharmacology, 2010, Volume: 25, Issue:3

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Circadian Rhythm; Drug Administration Schedule; Drug Monitoring; Female; Humans; Hyperprolactinemia; Isoindoles; Male; Middle Aged; Olanzapine; Prolactin; Risperidone; Schizophrenia; Thiazoles; Time Factors; Treatment Outcome

2010
A case of schizophrenia with Meige syndrome induced by long-term aripiprazole successfully treated with perospirone.
    Progress in neuro-psychopharmacology & biological psychiatry, 2011, Jan-15, Volume: 35, Issue:1

    Topics: Antipsychotic Agents; Aripiprazole; Female; Humans; Isoindoles; Meige Syndrome; Piperazines; Quinolones; Schizophrenia; Thiazoles; Young Adult

2011
Improvement in QTc prolongation induced by zotepine following a switch to perospirone.
    Psychiatry and clinical neurosciences, 2012, Volume: 66, Issue:3

    Topics: Antipsychotic Agents; Dibenzothiepins; Electrocardiography; Female; Haloperidol; Heart Rate; Humans; Isoindoles; Long QT Syndrome; Middle Aged; Schizophrenia; Thiazoles; Water-Electrolyte Imbalance

2012
State and trait markers of emotionally charged visual event-related potentials (P300) in drug-naïve schizophrenia.
    Psychiatry and clinical neurosciences, 2012, Volume: 66, Issue:4

    Topics: Adolescent; Adult; Antipsychotic Agents; Benzodiazepines; Case-Control Studies; Emotions; Event-Related Potentials, P300; Evoked Potentials, Visual; Facial Expression; Female; Humans; Isoindoles; Male; Olanzapine; Photic Stimulation; Psychomotor Performance; Reaction Time; Risperidone; Schizophrenia; Schizophrenic Psychology; Thiazoles

2012
[Perospirone therapy in elderly patients with schizophrenia].
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 2003, Volume: 105, Issue:10

    Topics: Aged; Antipsychotic Agents; Female; Humans; Indoles; Isoindoles; Male; Schizophrenia; Thiazoles

2003
Two cases of perospirone-induced mania in schizophrenia.
    The Journal of clinical psychiatry, 2004, Volume: 65, Issue:1

    Topics: Adolescent; Adult; Antipsychotic Agents; Bipolar Disorder; Female; Humans; Indoles; Isoindoles; Male; Schizophrenia; Thiazoles

2004
Use of perospirone for obesity and diabetes mellitus in patients with schizophrenia: three case reports.
    International clinical psychopharmacology, 2004, Volume: 19, Issue:1

    Topics: Adult; Antipsychotic Agents; Diabetes Mellitus, Type 2; Humans; Indoles; Isoindoles; Male; Middle Aged; Obesity; Schizophrenia; Thiazoles; Weight Gain

2004
[Treatment of "the premonitory state of schizophrenia" with atypical antipsychotics].
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 2004, Volume: 106, Issue:11

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Female; Humans; Indoles; Isoindoles; Male; Middle Aged; Olanzapine; Risperidone; Schizophrenia; Thiazoles

2004
Alteration in serum neural cell adhesion molecule in patients of schizophrenia.
    Human psychopharmacology, 2007, Volume: 22, Issue:2

    Topics: Adult; Age Factors; Antipsychotic Agents; Benzodiazepines; Blotting, Western; Chronic Disease; Dibenzothiazepines; Female; Humans; Indoles; Isoindoles; Male; Middle Aged; Molecular Weight; Neural Cell Adhesion Molecules; Olanzapine; Protein Isoforms; Quetiapine Fumarate; Risperidone; Schizophrenia; Thiazoles

2007
New-onset diabetic ketoacidosis induced by the addition of perospirone hydrochloride in a patient treated with risperidone.
    Internal medicine (Tokyo, Japan), 2007, Volume: 46, Issue:4

    Topics: Adult; Diabetic Ketoacidosis; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Follow-Up Studies; Humans; Indoles; Isoindoles; Male; Risk Assessment; Risperidone; Schizophrenia; Severity of Illness Index; Thiazoles; Treatment Outcome

2007
[Pharmacokinetics of perospirone hydrochloride at an excessive dose and changes in the serum prolactin level].
    Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology, 2007, Volume: 20, Issue:1

    Topics: Adult; Antipsychotic Agents; Chromatography, High Pressure Liquid; Consciousness Disorders; Enzyme-Linked Immunosorbent Assay; Female; Humans; Indoles; Isoindoles; Prolactin; Schizophrenia; Thiazoles; Time Factors

2007
Effective adjunctive use of tandospirone with perospirone for enhancing verbal memory and quality of life in schizophrenia.
    Progress in neuro-psychopharmacology & biological psychiatry, 2007, May-09, Volume: 31, Issue:4

    Topics: Adult; Anti-Anxiety Agents; Antipsychotic Agents; Follow-Up Studies; Humans; Indoles; Isoindoles; Male; Memory; Piperazines; Pyrimidines; Quality of Life; Schizophrenia; Schizophrenic Psychology; Thiazoles; Verbal Behavior

2007
Long-term perospirone treatment with a single dose at bedtime in schizophrenia: relevant to intermittent dopamine D2 receptor antagonism.
    Progress in neuro-psychopharmacology & biological psychiatry, 2008, Feb-15, Volume: 32, Issue:2

    Topics: Adult; Ambulatory Care; Antipsychotic Agents; Chromatography, High Pressure Liquid; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Indoles; Isoindoles; Longitudinal Studies; Male; Middle Aged; Schizophrenia; Schizophrenic Psychology; Secondary Prevention; Thiazoles; Treatment Outcome

2008