periplocin and Heart-Failure

periplocin has been researched along with Heart-Failure* in 2 studies

Other Studies

2 other study(ies) available for periplocin and Heart-Failure

ArticleYear
Periplocin Alleviates Cardiac Remodeling in DOCA-Salt-Induced Heart Failure Rats.
    Journal of cardiovascular translational research, 2023, Volume: 16, Issue:1

    Heart failure with preserved ejection fraction (HFpEF) is a common public health problem associated with increased morbidity and long-term mortality. However, effective treatment for HFpEF was not discovered yet. In the present study, we aimed to decipher the effects of Periplocin on DOCA-induced heart failure rats and explore the possible underlying mechanisms. We demonstrated that Periplocin could significantly attenuate cardiac structural remodeling and improve cardiac diastolic function. Of note, Periplocin significantly inhibited the recruitment of inflammatory and immune cells and decreased the expression of serum inflammatory cytokines. Meanwhile, Periplocin had the effect of cardiac glycosides to improve cardiomyocyte contractility and calcium transient amplitude. These findings indicate that Periplocin might be a potential medicine to treat HFpEF in patients.

    Topics: Animals; Desoxycorticosterone Acetate; Heart Failure; Myocytes, Cardiac; Rats; Stroke Volume; Ventricular Remodeling

2023
[Comparative evaluation of the effect of periplocin and other cardiac drugs in patients with circulatory insufficency].
    Sovetskaia meditsina, 1961, Volume: 25

    Topics: Cardiac Glycosides; Cardiotonic Agents; Diuretics; Glycosides; Heart Failure; Humans; Saponins

1961