Compounds > perifosine
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perifosine and Prostatic Neoplasms

perifosine has been researched along with Prostatic Neoplasms in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (80.00)29.6817
2010's2 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Adhami, VM; Ateeq, B; Choudhry, H; Hamid, A; Khan, MI; Khan, Q; Mukhtar, H; Rath, S; Siddiqui, IA; Zamzami, MA1
Ayala, G; Ding, Y; Frolov, A; Harper, JW; Hayes, TG; Ittmann, MM; Kadmon, D; Li, R; Lynch, RG; MacDonnell, V; Miles, BJ; Mims, MP; Thompson, TC; Tsai, MJ; Wheeler, TM; Yan, J1
Cerna, D; Coleman, CN; Falduto, MT; John-Aryankalayil, M; Magnuson, SR; Palayoor, ST; Simone, CB1
Dasmahapatra, GP; Kondapaka, SB; Roy, KK; Sausville, EA; Singh, SS1
Alley, MC; Dasmahapatra, GP; Didolkar, P; Ghosh, S; Roy, KK; Sausville, EA1
Arlen, PM; Chen, C; Chung, EJ; Dahut, WL; Daniels, A; Figg, WD; Gulley, J; Jones, E; Lee, MJ; Parnes, HL; Posadas, EM; Sparreboom, A; Steinberg, SM; Trepel, JB; Trout, A; Wright, J1
de Vere White, RW; Ghosh, P; Hwa, K; Lara, PN; Pan, CX; Vinall, RL1
Cambio, A; Chatta, G; Chee, KG; Evans, CP; Gandara, DR; Lara, PN; Longmate, J; Pan, CX; Pinski, J; Quinn, DI; Twardowski, P1
Bologna, M; Dolo, V; Festuccia, C; Gravina, GL; Millimaggi, D; Muzi, P; Vicentini, C1
Floryk, D; Thompson, TC1

Trials

3 trial(s) available for perifosine and Prostatic Neoplasms

ArticleYear
Bortezomib-mediated inhibition of steroid receptor coactivator-3 degradation leads to activated Akt.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Nov-15, Volume: 14, Issue:22

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Flow Cytometry; Histone Acetyltransferases; Humans; Immunohistochemistry; Male; Middle Aged; Neoadjuvant Therapy; NF-kappa B; Nuclear Receptor Coactivator 3; Phosphorylcholine; Prostate-Specific Antigen; Prostatectomy; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Pyrazines; RNA Interference; Trans-Activators

2008
A phase II study of perifosine in androgen independent prostate cancer.
    Cancer biology & therapy, 2005, Volume: 4, Issue:10

    Topics: Aged; Aged, 80 and over; Androgens; Antineoplastic Agents; Disease Progression; Drug Administration Schedule; Humans; Leukapheresis; Male; Middle Aged; Neoplasm Metastasis; Phosphorylcholine; Prostate-Specific Antigen; Prostatic Neoplasms; Time Factors; Treatment Outcome

2005
The AKT inhibitor perifosine in biochemically recurrent prostate cancer: a phase II California/Pittsburgh cancer consortium trial.
    Clinical genitourinary cancer, 2007, Volume: 5, Issue:7

    Topics: Aged; Androgen Antagonists; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Phosphorylcholine; Prostatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt

2007

Other Studies

7 other study(ies) available for perifosine and Prostatic Neoplasms

ArticleYear
AKT Inhibition Modulates H3K4 Demethylase Levels in PTEN-Null Prostate Cancer.
    Molecular cancer therapeutics, 2019, Volume: 18, Issue:2

    Topics: Acetylation; Animals; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Humans; Jumonji Domain-Containing Histone Demethylases; Male; Methylation; Mice; MicroRNAs; Nuclear Proteins; Phosphorylcholine; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Repressor Proteins; Xenograft Model Antitumor Assays

2019
Fractionated radiation therapy can induce a molecular profile for therapeutic targeting.
    Radiation research, 2010, Volume: 174, Issue:4

    Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Dose Fractionation, Radiation; Gene Expression Profiling; Histones; Humans; Male; Oligonucleotide Array Sequence Analysis; Phenotype; Phosphorylation; Phosphorylcholine; Prostatic Neoplasms; Radiotherapy Dosage; Reproducibility of Results; Time Factors

2010
Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation.
    Molecular cancer therapeutics, 2003, Volume: 2, Issue:11

    Topics: Cell Division; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Growth Substances; Humans; Male; Molecular Structure; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphorylcholine; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Up-Regulation

2003
In vitro combination treatment with perifosine and UCN-01 demonstrates synergism against prostate (PC-3) and lung (A549) epithelial adenocarcinoma cell lines.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Aug-01, Volume: 10, Issue:15

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Bromodeoxyuridine; Cell Cycle; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Humans; Immunoblotting; Lung Neoplasms; Male; Phosphorylcholine; Prostatic Neoplasms; Signal Transduction; Staurosporine; Time Factors

2004
Combination treatment of prostate cancer cell lines with bioactive soy isoflavones and perifosine causes increased growth arrest and/or apoptosis.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Oct-15, Volume: 13, Issue:20

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Glycine max; Humans; Inhibitory Concentration 50; Isoflavones; Male; Phosphorylation; Phosphorylcholine; Poly(ADP-ribose) Polymerases; Polysaccharides; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Receptors, Androgen; RNA, Small Interfering; Transfection

2007
Akt down-modulation induces apoptosis of human prostate cancer cells and synergizes with EGFR tyrosine kinase inhibitors.
    The Prostate, 2008, Jun-15, Volume: 68, Issue:9

    Topics: Apoptosis; Blotting, Western; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Drug Synergism; Enzyme Activation; Epidermal Growth Factor; Erlotinib Hydrochloride; Flow Cytometry; Humans; Male; Morpholines; Neoplasms, Hormone-Dependent; Phosphorylcholine; Prostatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Quinazolines

2008
Perifosine induces differentiation and cell death in prostate cancer cells.
    Cancer letters, 2008, Aug-08, Volume: 266, Issue:2

    Topics: Active Transport, Cell Nucleus; Androgens; Antineoplastic Agents; Apoptosis; Biomarkers; Cell Cycle; Cell Differentiation; Cell Growth Processes; Cell Line, Tumor; Cell Nucleus; Cyclic AMP Response Element-Binding Protein; Gene Expression; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Male; Neoplasms, Hormone-Dependent; Phosphorylcholine; Prostatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt

2008