perifosine has been researched along with Lung Neoplasms in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (37.50) | 29.6817 |
| 2010's | 9 (56.25) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Aiche, S; Bassermann, F; Becker, W; Canevari, G; Casale, E; Depaolini, SR; Ehrlich, HC; Felder, ER; Feuchtinger, A; Garz, AK; Gohlke, BO; Götze, K; Greif, PA; Hahne, H; Heinzlmeir, S; Helm, D; Huenges, J; Jeremias, I; Kayser, G; Klaeger, S; Koch, H; Koenig, PA; Kramer, K; Kuster, B; Médard, G; Meng, C; Petzoldt, S; Polzer, H; Preissner, R; Qiao, H; Reinecke, M; Reiter, K; Rueckert, L; Ruland, J; Ruprecht, B; Schlegl, J; Schmidt, T; Schneider, S; Schoof, M; Spiekermann, K; Tõnisson, N; Vick, B; Vooder, T; Walch, A; Wilhelm, M; Wu, Z; Zecha, J; Zolg, DP | 1 |
| Fujisawa, M; Matsukawa, A; Ohara, T; Tong, G; Yamaguchi, T; Yoshimura, T | 1 |
| André, N; Berges, R; Borge, L; Bourgarel, V; Braguer, D; Buric, D; Carré, M; Carrier, A; Le Grand, M; Montero, MP; Pasquier, E; Vasseur, S | 1 |
| Chen, CY; Cheng, YW; Hsu, NY; Lee, H; Lee, MC; Wang, YC; Wu, DW; Wu, JY; Wu, TC | 1 |
| Hong, Y; Shen, J; Zhang, J | 1 |
| Shen, J; Xu, L; Zhao, Q | 1 |
| Chanvorachote, P; Pongrakhananon, V; Srinual, S | 1 |
| Fichtner, I; Wenzel, J; Zeisig, R | 1 |
| Fichtner, I; Habedank, S; Haider, W; Wenzel, J; Zeisig, R | 1 |
| Elrod, HA; Khuri, FR; Sun, SY; Yue, P | 1 |
| Fu, L; Khuri, FR; Kim, YA; Lonial, S; Sun, SY; Wang, X; Wu, X; Yue, P | 1 |
| Abu-Asab, MS; Castillo, SS; Dennis, PA; Gills, JJ; Goldkorn, T; Kozikowski, AP; LoPiccolo, J; Marceau, C; Tsokos, M; Zhang, C | 1 |
| Li, P; Luo, X; Ma, Z; Wang, X; Zhai, S; Zhu, L | 1 |
| Alley, MC; Dasmahapatra, GP; Didolkar, P; Ghosh, S; Roy, KK; Sausville, EA | 1 |
| Baetz, T; Belanger, K; Davis, M; Eisenhauer, E; Ernst, DS; Lohmann, R; Smylie, M; Wainman, N | 1 |
| Elrod, HA; Khuri, FR; Lin, YD; Lonial, S; Sun, SY; Wang, X; Yue, P | 1 |
1 trial(s) available for perifosine and Lung Neoplasms
| Article | Year |
|---|---|
Phase II study of perifosine in previously untreated patients with metastatic melanoma.
Topics: Adult; Aged; Aged, 80 and over; Arthralgia; Chondrocalcinosis; Female; Humans; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Melanoma; Middle Aged; Phosphorylcholine | 2005 |
15 other study(ies) available for perifosine and Lung Neoplasms
| Article | Year |
|---|---|
The target landscape of clinical kinase drugs.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cytokines; Drug Discovery; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Lung Neoplasms; Mice; Molecular Targeted Therapy; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proteomics; Xenograft Model Antitumor Assays | 2017 |
PolyI:C suppresses TGF-β1-induced Akt phosphorylation and reduces the motility of A549 lung carcinoma cells.
Topics: A549 Cells; Adenocarcinoma, Bronchiolo-Alveolar; Cell Movement; Epithelial-Mesenchymal Transition; Humans; Lung Neoplasms; Organometallic Compounds; Phosphatidylinositol 3-Kinase; Phosphorylation; Phosphorylcholine; Poly I-C; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Recombinant Proteins; Signal Transduction; Toll-Like Receptor 3; Transforming Growth Factor beta1 | 2021 |
Akt targeting as a strategy to boost chemotherapy efficacy in non-small cell lung cancer through metabolism suppression.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Culture Techniques; Cell Cycle Checkpoints; Cell Line, Tumor; Disease Models, Animal; Energy Metabolism; Glycolysis; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Mice; Mitochondria; Paclitaxel; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Signal Transduction; Xenograft Model Antitumor Assays | 2017 |
FHIT loss confers cisplatin resistance in lung cancer via the AKT/NF-κB/Slug-mediated PUMA reduction.
Topics: Acid Anhydride Hydrolases; Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Non-Small-Cell Lung; Cisplatin; Drug Resistance, Neoplasm; Female; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Neoplasm Proteins; Neoplasm Transplantation; Nitriles; Phosphorylcholine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Snail Family Transcription Factors; Sulfones; Transcription Factor RelA; Transcription Factors; Transplantation, Heterologous; Treatment Outcome | 2015 |
Combination treatment with perifosine and MEK-162 demonstrates synergism against lung cancer cells in vitro and in vivo.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; Drug Synergism; Humans; Lung Neoplasms; MAP Kinase Kinase Kinases; Mice; Phosphorylcholine; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Xenograft Model Antitumor Assays | 2015 |
Perifosine and ABT-737 synergistically inhibit lung cancer cells in vitro and in vivo.
Topics: A549 Cells; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; Lung Neoplasms; Mice; Mice, Nude; Nitrophenols; Phosphorylcholine; Piperazines; Sulfonamides; Treatment Outcome | 2016 |
Suppression of cancer stem-like phenotypes in NCI-H460 lung cancer cells by vanillin through an Akt-dependent pathway.
Topics: AC133 Antigen; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Benzaldehydes; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Colony-Forming Units Assay; Humans; Lung Neoplasms; Nanog Homeobox Protein; Neoplastic Stem Cells; Octamer Transcription Factor-3; Phosphorylcholine; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-akt; Retinal Dehydrogenase; Signal Transduction; Spheroids, Cellular; Vanilla | 2017 |
Inhibition of breast cancer metastasis by dual liposomes to disturb complex formation.
Topics: Animals; Antineoplastic Agents; Blood Platelets; Breast Neoplasms; Cell Line, Tumor; Dipyridamole; Drug Combinations; Female; Humans; Liposomes; Lung Neoplasms; Metallothionein 3; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; Neoplastic Cells, Circulating; Phosphorylcholine; Platelet Aggregation Inhibitors | 2009 |
Inhibition of pulmonary metastasis in a human MT3 breast cancer xenograft model by dual liposomes preventing intravasal fibrin clot formation.
Topics: Animals; Antineoplastic Agents; Blood Coagulation; Blood Vessels; Cell Line, Tumor; Dipyridamole; Female; Fibrin; Humans; Liposomes; Lung; Lung Neoplasms; Mammary Neoplasms, Experimental; Metallothionein 3; Mice; Mice, Nude; Neoplasm Metastasis; Phosphorylcholine; Platelet Aggregation Inhibitors; Xenograft Model Antitumor Assays | 2010 |
Celecoxib antagonizes perifosine's anticancer activity involving a cyclooxygenase-2-dependent mechanism.
Topics: Antineoplastic Agents; Base Sequence; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Celecoxib; Cell Line, Tumor; Cyclooxygenase 2; Drug Screening Assays, Antitumor; Enzyme-Linked Immunosorbent Assay; Gene Silencing; Humans; Immunohistochemistry; Lung Neoplasms; Phosphorylcholine; Pyrazoles; RNA, Small Interfering; Sulfonamides | 2009 |
Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy.
Topics: Animals; Autophagy; Cell Cycle Proteins; Cell Line, Tumor; Chloroquine; F-Box Proteins; F-Box-WD Repeat-Containing Protein 7; Female; Glycogen Synthase Kinase 3; HCT116 Cells; Humans; Lung Neoplasms; Mice; Mice, Nude; Oncogene Protein v-akt; Phosphorylation; Phosphorylcholine; Protein Kinases; Signal Transduction; TOR Serine-Threonine Kinases; Ubiquitin-Protein Ligases; Xenograft Model Antitumor Assays | 2009 |
Ceramide mediates nanovesicle shedding and cell death in response to phosphatidylinositol ether lipid analogs and perifosine.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Ceramides; ErbB Receptors; Female; Humans; Lung Neoplasms; Mice; Mice, Nude; Phosphatidylinositol Phosphates; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Pyridines; Receptor, IGF Type 1; RNA Interference; RNA, Small Interfering; Secretory Vesicles; Sphingomyelin Phosphodiesterase; Transplantation, Heterologous | 2012 |
Perifosine enhances mTORC1-targeted cancer therapy by activation of GSK3β in NSCLC cells.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Female; Gene Knockdown Techniques; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Lung Neoplasms; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Nude; Molecular Targeted Therapy; Multiprotein Complexes; Phosphorylation; Phosphorylcholine; Proteins; RNA, Small Interfering; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2012 |
In vitro combination treatment with perifosine and UCN-01 demonstrates synergism against prostate (PC-3) and lung (A549) epithelial adenocarcinoma cell lines.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Bromodeoxyuridine; Cell Cycle; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Humans; Immunoblotting; Lung Neoplasms; Male; Phosphorylcholine; Prostatic Neoplasms; Signal Transduction; Staurosporine; Time Factors | 2004 |
The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 8; Cell Line, Tumor; Cell Survival; DNA Fragmentation; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Silencing; Humans; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; MAP Kinase Signaling System; Phosphorylation; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand; Up-Regulation | 2007 |