Compounds > perifosine
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perifosine and Local Neoplasm Recurrence

perifosine has been researched along with Local Neoplasm Recurrence in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (25.00)29.6817
2010's5 (62.50)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Abrey, LE; DeAngelis, LM; Gavrilovic, I; Holland, EC; Kaley, TJ; Lacouture, ME; Lassman, AB; Ludwig, E; Mellinghoff, IK; Nolan, C; Omuro, A; Panageas, KS; Pentsova, EI1
Chin, M; Kato, K; Kawamoto, H; Kosaka, Y; Matsumoto, K; Mugishima, H; Shichino, H1
Becher, OJ; Cheung, NV; De Braganca, KC; Dunkel, IJ; Gilheeney, SW; Haque, S; Huse, JT; Khakoo, Y; Kolesar, JM; Kramer, K; Kushner, BH; Lyden, DC; Millard, NE; Modak, S; Spasojevic, I; Trippett, TM1
Aoki, D; Aoki, Y; Hasegawa, K; Kagabu, M; Kamiura, S; Kimura, T; Mabuchi, S; Mizuno, M; Ochiai, K; Oda, K; Okamoto, A; Saito, T; Takehara, K; Yamaguchi, S; Yunokawa, M1
Abrey, LE; DeAngelis, LM; Gavrilovic, IT; Holland, EC; Kaley, TJ; Lassman, AB; Mellinghoff, IK; Nolan, C; Panageas, KS1
Basu, EM; Becher, OJ; Cheung, NV; Dunkel, IJ; Kramer, K; Kushner, BH; Modak, S; Roberts, SS1
Ansari, R; Argiris, A; Cohen, E; Dancey, J; Esparaz, B; Karrison, T; Lu, Y; Mauer, A; Pins, M; Vokes, E; Wong, S1
Cambio, A; Chatta, G; Chee, KG; Evans, CP; Gandara, DR; Lara, PN; Longmate, J; Pan, CX; Pinski, J; Quinn, DI; Twardowski, P1

Trials

8 trial(s) available for perifosine and Local Neoplasm Recurrence

ArticleYear
Phase I clinical trial of temsirolimus and perifosine for recurrent glioblastoma.
    Annals of clinical and translational neurology, 2020, Volume: 7, Issue:4

    Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Drug Therapy, Combination; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Phosphorylcholine; Prospective Studies; Proto-Oncogene Proteins c-akt; Sirolimus; TOR Serine-Threonine Kinases; Young Adult

2020
Phase I study of perifosine monotherapy in patients with recurrent or refractory neuroblastoma.
    Pediatric blood & cancer, 2017, Volume: 64, Issue:11

    Topics: Adolescent; Adult; Child; Child, Preschool; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Humans; Male; Maximum Tolerated Dose; Neoplasm Recurrence, Local; Neoplasm Staging; Neuroblastoma; Phosphorylcholine; Prognosis; Proto-Oncogene Proteins c-akt; Salvage Therapy; Signal Transduction; Survival Rate; Young Adult

2017
A phase I study of single-agent perifosine for recurrent or refractory pediatric CNS and solid tumors.
    PloS one, 2017, Volume: 12, Issue:6

    Topics: Adolescent; Antineoplastic Agents; Central Nervous System Neoplasms; Child; Child, Preschool; Drug Administration Schedule; Ependymoma; Female; Glioma; Humans; Hyperuricemia; Male; Medulloblastoma; Neoplasm Recurrence, Local; Neuroblastoma; Neutropenia; Phosphorylcholine; Sarcoma, Ewing; Treatment Outcome; Wilms Tumor

2017
Phase II basket trial of perifosine monotherapy for recurrent gynecologic cancer with or without PIK3CA mutations.
    Investigational new drugs, 2017, Volume: 35, Issue:6

    Topics: Adult; Aged; Class I Phosphatidylinositol 3-Kinases; Cohort Studies; Female; Follow-Up Studies; Genital Neoplasms, Female; Humans; Middle Aged; Mutation; Neoplasm Recurrence, Local; Phosphorylcholine; Prognosis

2017
Phase II trial of an AKT inhibitor (perifosine) for recurrent glioblastoma.
    Journal of neuro-oncology, 2019, Volume: 144, Issue:2

    Topics: Adult; Aged; Brain Neoplasms; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Phosphorylcholine; Prognosis; Prospective Studies; Proto-Oncogene Proteins c-akt; Survival Rate; Young Adult

2019
A phase I/Ib trial targeting the Pi3k/Akt pathway using perifosine: Long-term progression-free survival of patients with resistant neuroblastoma.
    International journal of cancer, 2017, Jan-15, Volume: 140, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Agents; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Male; Neoplasm Recurrence, Local; Neuroblastoma; Phosphatidylinositol 3-Kinases; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Signal Transduction; Young Adult

2017
A phase II trial of perifosine, an oral alkylphospholipid, in recurrent or metastatic head and neck cancer.
    Cancer biology & therapy, 2006, Volume: 5, Issue:7

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; p38 Mitogen-Activated Protein Kinases; Phospholipids; Phosphorylcholine; Proto-Oncogene Proteins c-akt

2006
The AKT inhibitor perifosine in biochemically recurrent prostate cancer: a phase II California/Pittsburgh cancer consortium trial.
    Clinical genitourinary cancer, 2007, Volume: 5, Issue:7

    Topics: Aged; Androgen Antagonists; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Phosphorylcholine; Prostatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt

2007