Compounds > perifosine
Page last updated: 2024-09-04

perifosine and Glioma

perifosine has been researched along with Glioma in 5 studies

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Becher, OJ; Cheung, NV; De Braganca, KC; Dunkel, IJ; Gilheeney, SW; Haque, S; Huse, JT; Khakoo, Y; Kolesar, JM; Kramer, K; Kushner, BH; Lyden, DC; Millard, NE; Modak, S; Spasojevic, I; Trippett, TM1
Ho, SL; Pisapia, DJ; Singh, R; Souweidane, MM; Zhou, Z1
Albrecht, S; Becher, OJ; Gall, S; Hambardzumyan, D; Helmy, K; Hiner, RL; Holland, EC; Huse, JT; Jabado, N; MacDonald, TJ; Nazarian, J; Walker, TR1
Holland, EC; Momota, H; Nerio, E1
Burgan, WE; Camphausen, K; Carter, DJ; de la Peña, L; Hollingshead, MG; Satyamitra, M; Tofilon, PJ1

Trials

1 trial(s) available for perifosine and Glioma

ArticleYear
A phase I study of single-agent perifosine for recurrent or refractory pediatric CNS and solid tumors.
    PloS one, 2017, Volume: 12, Issue:6

    Topics: Adolescent; Antineoplastic Agents; Central Nervous System Neoplasms; Child; Child, Preschool; Drug Administration Schedule; Ependymoma; Female; Glioma; Humans; Hyperuricemia; Male; Medulloblastoma; Neoplasm Recurrence, Local; Neuroblastoma; Neutropenia; Phosphorylcholine; Sarcoma, Ewing; Treatment Outcome; Wilms Tumor

2017

Other Studies

4 other study(ies) available for perifosine and Glioma

ArticleYear
Toxicity evaluation of convection-enhanced delivery of small-molecule kinase inhibitors in naïve mouse brainstem.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2015, Volume: 31, Issue:4

    Topics: Animals; Animals, Newborn; Brain Stem; Cell Line, Tumor; Cell Proliferation; Convection; Dasatinib; Dose-Response Relationship, Drug; Drug Delivery Systems; Everolimus; Glioma; Intracranial Hemorrhages; Mice; Phosphorylcholine; Protein Kinase Inhibitors; Time Factors

2015
Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma.
    Cancer research, 2010, Mar-15, Volume: 70, Issue:6

    Topics: Animals; Brain Stem Neoplasms; Combined Modality Therapy; Disease Models, Animal; Genetic Engineering; Glioma; Inbreeding; Mice; Mice, Inbred BALB C; Phosphorylcholine; Receptor, Platelet-Derived Growth Factor alpha

2010
Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo.
    Cancer research, 2005, Aug-15, Volume: 65, Issue:16

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; CDC2-CDC28 Kinases; Cell Growth Processes; Cell Line, Tumor; Cyclin-Dependent Kinase 2; Dacarbazine; Dose-Response Relationship, Drug; Drug Synergism; G1 Phase; G2 Phase; Glioma; Humans; Mice; Mice, Transgenic; Phosphorylcholine; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Temozolomide; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays

2005
Inhibition of Akt by the alkylphospholipid perifosine does not enhance the radiosensitivity of human glioma cells.
    Molecular cancer therapeutics, 2006, Volume: 5, Issue:6

    Topics: Animals; Apoptosis; Brain Neoplasms; Combined Modality Therapy; Female; Glioma; Humans; Immunohistochemistry; Mice; Mice, Nude; Phosphorylation; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Radiation Tolerance; Transplantation, Heterologous; Tumor Cells, Cultured; Tumor Stem Cell Assay

2006