Page last updated: 2024-09-04

perifosine and Cancer of Head

perifosine has been researched along with Cancer of Head in 5 studies

Research

Studies (5)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (80.00)	29.6817
2010's	1 (20.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chen, GZ; Elrod, HA; Fu, L; Khuri, FR; Li, B; Lin, YD; Oh, Y; Shin, DM; Sun, SY; Tao, H; Yue, P	1
Schellens, JH; van Blitterswijk, WJ; Verheij, M; Vink, SR	1
Begg, AC; Lagerwerf, S; Mesman, E; Schellens, JH; van Blitterswijk, WJ; Verheij, M; Vink, SR	1
Ansari, R; Argiris, A; Cohen, E; Dancey, J; Esparaz, B; Karrison, T; Lu, Y; Mauer, A; Pins, M; Vokes, E; Wong, S	1
Gutkind, JS; Lahusen, T; Patel, V; Sausville, EA; Senderowicz, AM; Sy, T	1

Trials

1 trial(s) available for perifosine and Cancer of Head

Article	Year
A phase II trial of perifosine, an oral alkylphospholipid, in recurrent or metastatic head and neck cancer. Cancer biology & therapy, 2006, Volume: 5, Issue:7 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; p38 Mitogen-Activated Protein Kinases; Phospholipids; Phosphorylcholine; Proto-Oncogene Proteins c-akt	2006

Article

Year

A phase II trial of perifosine, an oral alkylphospholipid, in recurrent or metastatic head and neck cancer.

Cancer biology & therapy, 2006, Volume: 5, Issue:7

Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; p38 Mitogen-Activated Protein Kinases; Phospholipids; Phosphorylcholine; Proto-Oncogene Proteins c-akt

2006

Other Studies

4 other study(ies) available for perifosine and Cancer of Head

Article	Year
c-Jun NH2-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL. Molecular cancer, 2010, Dec-20, Volume: 9 Topics: Animals; Anthracenes; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Glutathione; Head and Neck Neoplasms; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Nude; Phosphorylcholine; Reactive Oxygen Species; Receptors, TNF-Related Apoptosis-Inducing Ligand; RNA, Small Interfering; TNF-Related Apoptosis-Inducing Ligand; Xenograft Model Antitumor Assays	2010
Tumor and normal tissue pharmacokinetics of perifosine, an oral anti-cancer alkylphospholipid. Investigational new drugs, 2005, Volume: 23, Issue:4 Topics: Administration, Oral; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Female; Head and Neck Neoplasms; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Phosphorylcholine; Tissue Distribution; Vulvar Neoplasms	2005
Radiosensitization of squamous cell carcinoma by the alkylphospholipid perifosine in cell culture and xenografts. Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Mar-01, Volume: 12, Issue:5 Topics: Animals; Apoptosis; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; G2 Phase; Head and Neck Neoplasms; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphorylcholine; Radiation-Sensitizing Agents; Rhodamines; Transplantation, Heterologous; Tumor Cells, Cultured; Tumor Stem Cell Assay; X-Rays	2006
Perifosine, a novel alkylphospholipid, induces p21(WAF1) expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest. Cancer research, 2002, Mar-01, Volume: 62, Issue:5 Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; CDC2 Protein Kinase; Cell Cycle; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; DNA; Head and Neck Neoplasms; Humans; Phosphorylcholine; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2002