Compounds > perifosine
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perifosine and Breast Cancer

perifosine has been researched along with Breast Cancer in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (8.33)18.2507
2000's2 (16.67)29.6817
2010's8 (66.67)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
He, N; Lv, Z; Wang, S; Zhao, W1
Dedes, KJ; Fink, D; Gutsche, K; Imesch, P; Samartzis, EP; Stucki, M1
Buchholz, S; Engel, JB; Kwok, CW; Ortmann, O; Seitz, S; Treeck, O1
Friedman, DR; Hagiopian, MM; Holohan, B; Huang, E; Lai, TP; Shay, JW; Wright, WE1
Fichtner, I; Wenzel, J; Zeisig, R1
Cheng, JQ; Coppola, D; Guo, JP1
Kang, J; Montales, MT; Prior, RL; Rahal, OM; Rogers, TJ; Simmen, RC; Wu, X1
Ronen, SM; Su, JS; Woods, SM1
Li, J; Li, X; Lin, X; Wang, Q; Zhang, P; Zhang, X; Zhao, M1
Block, M; Emons, G; Fister, S; Gründker, C; Günthert, AR; Hemmerlein, B; Kubin, J; Mueller, MD; Wilkens, L1
Clemons, M; Crump, RM; Dancey, JE; Dent, S; Hedley, D; Leighl, NB; Moore, MJ; Pond, GR; Tozer, R; Vandenberg, TA; Warr, DG1
Arndt, D; Fichtner, I; Stahn, R; Zeisig, R1

Trials

1 trial(s) available for perifosine and Breast Cancer

ArticleYear
A Phase 2 study of perifosine in advanced or metastatic breast cancer.
    Breast cancer research and treatment, 2008, Volume: 108, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Female; Humans; Kaplan-Meier Estimate; Middle Aged; Phosphorylcholine; Treatment Outcome

2008

Other Studies

11 other study(ies) available for perifosine and Breast Cancer

ArticleYear
MicroRNA analysis of NCI-60 human cancer cells indicates that miR-720 and miR-887 are potential therapeutic biomarkers for breast cancer.
    Drug discoveries & therapeutics, 2020, Sep-08, Volume: 14, Issue:4

    Topics: Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Databases, Genetic; Female; Fluorouracil; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Phosphorylcholine; Survival Analysis; Up-Regulation

2020
Loss of ARID1A expression sensitizes cancer cells to PI3K- and AKT-inhibition.
    Oncotarget, 2014, Jul-30, Volume: 5, Issue:14

    Topics: Aminopyridines; Apoptosis; Breast Neoplasms; DNA-Binding Proteins; Female; Gene Knockdown Techniques; Heterocyclic Compounds, 3-Ring; Humans; MCF-7 Cells; Morpholines; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphorylcholine; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Small Interfering; Signal Transduction; Transcription Factors; Transfection

2014
Receptors for luteinizing hormone-releasing hormone (GnRH) as therapeutic targets in triple negative breast cancers (TNBC).
    Targeted oncology, 2015, Volume: 10, Issue:3

    Topics: Aniline Compounds; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cisplatin; DNA Mutational Analysis; Dose-Response Relationship, Drug; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Gonadotropin-Releasing Hormone; Humans; Phosphatidylinositol 3-Kinases; Phosphorylcholine; Receptors, LHRH; Triple Negative Breast Neoplasms; Triptorelin Pamoate

2015
Perifosine as a potential novel anti-telomerase therapy.
    Oncotarget, 2015, Sep-08, Volume: 6, Issue:26

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Clinical Trials, Phase II as Topic; Enzyme Inhibitors; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasms; Phosphorylcholine; Telomerase; Telomere; Xenograft Model Antitumor Assays

2015
Inhibition of breast cancer metastasis by dual liposomes to disturb complex formation.
    International journal of pharmaceutics, 2009, Mar-31, Volume: 370, Issue:1-2

    Topics: Animals; Antineoplastic Agents; Blood Platelets; Breast Neoplasms; Cell Line, Tumor; Dipyridamole; Drug Combinations; Female; Humans; Liposomes; Lung Neoplasms; Metallothionein 3; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; Neoplastic Cells, Circulating; Phosphorylcholine; Platelet Aggregation Inhibitors

2009
IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation.
    The Journal of biological chemistry, 2011, Oct-28, Volume: 286, Issue:43

    Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; Enzyme Activation; Female; Gene Deletion; HEK293 Cells; Heterocyclic Compounds, 3-Ring; Humans; I-kappa B Kinase; Mammary Neoplasms, Animal; Mice; Mice, Knockout; NIH 3T3 Cells; Oxadiazoles; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphorylcholine; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Ribonucleosides; Trans-Activators; Transcription Factors

2011
Repression of mammosphere formation of human breast cancer cells by soy isoflavone genistein and blueberry polyphenolic acids suggests diet-mediated targeting of cancer stem-like/progenitor cells.
    Carcinogenesis, 2012, Volume: 33, Issue:3

    Topics: Animals; Blueberry Plants; Breast Neoplasms; CD24 Antigen; Cell Line, Tumor; Female; Genistein; Humans; Hyaluronan Receptors; Isoflavones; Mammary Neoplasms, Experimental; Mice; Neoplastic Stem Cells; Phosphorylcholine; Plant Extracts; Polyphenols; PTEN Phosphohydrolase; Soybean Proteins

2012
Metabolic consequences of treatment with AKT inhibitor perifosine in breast cancer cells.
    NMR in biomedicine, 2012, Volume: 25, Issue:2

    Topics: Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Choline; Choline Kinase; Choline-Phosphate Cytidylyltransferase; Female; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Diester Hydrolases; Phosphorylcholine; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction

2012
Perifosine downregulates MDR1 gene expression and reverses multidrug-resistant phenotype by inhibiting PI3K/Akt/NF-κB signaling pathway in a human breast cancer cell line.
    Neoplasma, 2012, Volume: 59, Issue:3

    Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Down-Regulation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Elafin; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; NF-kappa B; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Real-Time Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured

2012
Inhibition of the AKT/mTOR and erbB pathways by gefitinib, perifosine and analogs of gonadotropin-releasing hormone I and II to overcome tamoxifen resistance in breast cancer cells.
    International journal of oncology, 2012, Volume: 41, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Class I Phosphatidylinositol 3-Kinases; Comparative Genomic Hybridization; Drug Resistance, Neoplasm; Enzyme Activation; ErbB Receptors; Female; Gefitinib; Gene Expression Regulation, Neoplastic; Gonadotropin-Releasing Hormone; Humans; MCF-7 Cells; Phosphatidylinositol 3-Kinases; Phosphorylcholine; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Quinazolines; Receptors, LHRH; Signal Transduction; Tamoxifen; TOR Serine-Threonine Kinases

2012
Physical properties and pharmacological activity in vitro and in vivo of optimised liposomes prepared from a new cancerostatic alkylphospholipid.
    Biochimica et biophysica acta, 1998, Nov-11, Volume: 1414, Issue:1-2

    Topics: Animals; Breast Neoplasms; Cell Division; Female; Humans; Liposomes; Metallothionein 3; Mice; Mice, Nude; Phosphorylcholine; Tumor Cells, Cultured

1998