perifosine has been researched along with Breast Cancer in 12 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (8.33) | 18.2507 |
2000's | 2 (16.67) | 29.6817 |
2010's | 8 (66.67) | 24.3611 |
2020's | 1 (8.33) | 2.80 |
Authors | Studies |
---|---|
He, N; Lv, Z; Wang, S; Zhao, W | 1 |
Dedes, KJ; Fink, D; Gutsche, K; Imesch, P; Samartzis, EP; Stucki, M | 1 |
Buchholz, S; Engel, JB; Kwok, CW; Ortmann, O; Seitz, S; Treeck, O | 1 |
Friedman, DR; Hagiopian, MM; Holohan, B; Huang, E; Lai, TP; Shay, JW; Wright, WE | 1 |
Fichtner, I; Wenzel, J; Zeisig, R | 1 |
Cheng, JQ; Coppola, D; Guo, JP | 1 |
Kang, J; Montales, MT; Prior, RL; Rahal, OM; Rogers, TJ; Simmen, RC; Wu, X | 1 |
Ronen, SM; Su, JS; Woods, SM | 1 |
Li, J; Li, X; Lin, X; Wang, Q; Zhang, P; Zhang, X; Zhao, M | 1 |
Block, M; Emons, G; Fister, S; Gründker, C; Günthert, AR; Hemmerlein, B; Kubin, J; Mueller, MD; Wilkens, L | 1 |
Clemons, M; Crump, RM; Dancey, JE; Dent, S; Hedley, D; Leighl, NB; Moore, MJ; Pond, GR; Tozer, R; Vandenberg, TA; Warr, DG | 1 |
Arndt, D; Fichtner, I; Stahn, R; Zeisig, R | 1 |
1 trial(s) available for perifosine and Breast Cancer
Article | Year |
---|---|
A Phase 2 study of perifosine in advanced or metastatic breast cancer.
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Female; Humans; Kaplan-Meier Estimate; Middle Aged; Phosphorylcholine; Treatment Outcome | 2008 |
11 other study(ies) available for perifosine and Breast Cancer
Article | Year |
---|---|
MicroRNA analysis of NCI-60 human cancer cells indicates that miR-720 and miR-887 are potential therapeutic biomarkers for breast cancer.
Topics: Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Databases, Genetic; Female; Fluorouracil; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Phosphorylcholine; Survival Analysis; Up-Regulation | 2020 |
Loss of ARID1A expression sensitizes cancer cells to PI3K- and AKT-inhibition.
Topics: Aminopyridines; Apoptosis; Breast Neoplasms; DNA-Binding Proteins; Female; Gene Knockdown Techniques; Heterocyclic Compounds, 3-Ring; Humans; MCF-7 Cells; Morpholines; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphorylcholine; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Small Interfering; Signal Transduction; Transcription Factors; Transfection | 2014 |
Receptors for luteinizing hormone-releasing hormone (GnRH) as therapeutic targets in triple negative breast cancers (TNBC).
Topics: Aniline Compounds; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cisplatin; DNA Mutational Analysis; Dose-Response Relationship, Drug; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Gonadotropin-Releasing Hormone; Humans; Phosphatidylinositol 3-Kinases; Phosphorylcholine; Receptors, LHRH; Triple Negative Breast Neoplasms; Triptorelin Pamoate | 2015 |
Perifosine as a potential novel anti-telomerase therapy.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Clinical Trials, Phase II as Topic; Enzyme Inhibitors; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasms; Phosphorylcholine; Telomerase; Telomere; Xenograft Model Antitumor Assays | 2015 |
Inhibition of breast cancer metastasis by dual liposomes to disturb complex formation.
Topics: Animals; Antineoplastic Agents; Blood Platelets; Breast Neoplasms; Cell Line, Tumor; Dipyridamole; Drug Combinations; Female; Humans; Liposomes; Lung Neoplasms; Metallothionein 3; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; Neoplastic Cells, Circulating; Phosphorylcholine; Platelet Aggregation Inhibitors | 2009 |
IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; Enzyme Activation; Female; Gene Deletion; HEK293 Cells; Heterocyclic Compounds, 3-Ring; Humans; I-kappa B Kinase; Mammary Neoplasms, Animal; Mice; Mice, Knockout; NIH 3T3 Cells; Oxadiazoles; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphorylcholine; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Ribonucleosides; Trans-Activators; Transcription Factors | 2011 |
Repression of mammosphere formation of human breast cancer cells by soy isoflavone genistein and blueberry polyphenolic acids suggests diet-mediated targeting of cancer stem-like/progenitor cells.
Topics: Animals; Blueberry Plants; Breast Neoplasms; CD24 Antigen; Cell Line, Tumor; Female; Genistein; Humans; Hyaluronan Receptors; Isoflavones; Mammary Neoplasms, Experimental; Mice; Neoplastic Stem Cells; Phosphorylcholine; Plant Extracts; Polyphenols; PTEN Phosphohydrolase; Soybean Proteins | 2012 |
Metabolic consequences of treatment with AKT inhibitor perifosine in breast cancer cells.
Topics: Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Choline; Choline Kinase; Choline-Phosphate Cytidylyltransferase; Female; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Diester Hydrolases; Phosphorylcholine; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction | 2012 |
Perifosine downregulates MDR1 gene expression and reverses multidrug-resistant phenotype by inhibiting PI3K/Akt/NF-κB signaling pathway in a human breast cancer cell line.
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Down-Regulation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Elafin; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; NF-kappa B; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Real-Time Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured | 2012 |
Inhibition of the AKT/mTOR and erbB pathways by gefitinib, perifosine and analogs of gonadotropin-releasing hormone I and II to overcome tamoxifen resistance in breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Class I Phosphatidylinositol 3-Kinases; Comparative Genomic Hybridization; Drug Resistance, Neoplasm; Enzyme Activation; ErbB Receptors; Female; Gefitinib; Gene Expression Regulation, Neoplastic; Gonadotropin-Releasing Hormone; Humans; MCF-7 Cells; Phosphatidylinositol 3-Kinases; Phosphorylcholine; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Quinazolines; Receptors, LHRH; Signal Transduction; Tamoxifen; TOR Serine-Threonine Kinases | 2012 |
Physical properties and pharmacological activity in vitro and in vivo of optimised liposomes prepared from a new cancerostatic alkylphospholipid.
Topics: Animals; Breast Neoplasms; Cell Division; Female; Humans; Liposomes; Metallothionein 3; Mice; Mice, Nude; Phosphorylcholine; Tumor Cells, Cultured | 1998 |