Compounds > perifosine
Page last updated: 2024-09-04

perifosine and Brain Neoplasms

perifosine has been researched along with Brain Neoplasms in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (25.00)29.6817
2010's5 (62.50)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Abrey, LE; DeAngelis, LM; Gavrilovic, I; Holland, EC; Kaley, TJ; Lacouture, ME; Lassman, AB; Ludwig, E; Mellinghoff, IK; Nolan, C; Omuro, A; Panageas, KS; Pentsova, EI1
Abrey, LE; DeAngelis, LM; Gavrilovic, IT; Holland, EC; Kaley, TJ; Lassman, AB; Mellinghoff, IK; Nolan, C; Panageas, KS1
Fu, LS; Guo, J; Qin, LS; Sun, G; Xu, J; Yu, ZQ; Zhang, SM; Zhu, J1
Carrasco, MP; Jiménez-López, JM; Marco, C; Ríos, A; Ríos-Marco, P1
Li, Z; Nakamura, K; Oh, DY; Thiele, CJ1
Belden, CJ; Fadul, CE; Harris, BT; Israel, MA; Pastel, DA; Paulsen, K; Ran, C; Roberts, DW; Valdes, PA1
Holland, EC; Momota, H; Nerio, E1
Burgan, WE; Camphausen, K; Carter, DJ; de la Peña, L; Hollingshead, MG; Satyamitra, M; Tofilon, PJ1

Reviews

1 review(s) available for perifosine and Brain Neoplasms

ArticleYear
Genetics of glioblastoma: a window into its imaging and histopathologic variability.
    Radiographics : a review publication of the Radiological Society of North America, Inc, 2011, Volume: 31, Issue:6

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Proliferation; Cell Survival; Erlotinib Hydrochloride; Gefitinib; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Magnetic Resonance Imaging; Neoplasm Invasiveness; Neovascularization, Pathologic; Phosphorylcholine; Protein Kinase Inhibitors; Quinazolines

2011

Trials

2 trial(s) available for perifosine and Brain Neoplasms

ArticleYear
Phase I clinical trial of temsirolimus and perifosine for recurrent glioblastoma.
    Annals of clinical and translational neurology, 2020, Volume: 7, Issue:4

    Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Drug Therapy, Combination; Female; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Phosphorylcholine; Prospective Studies; Proto-Oncogene Proteins c-akt; Sirolimus; TOR Serine-Threonine Kinases; Young Adult

2020
Phase II trial of an AKT inhibitor (perifosine) for recurrent glioblastoma.
    Journal of neuro-oncology, 2019, Volume: 144, Issue:2

    Topics: Adult; Aged; Brain Neoplasms; Female; Follow-Up Studies; Glioblastoma; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Phosphorylcholine; Prognosis; Prospective Studies; Proto-Oncogene Proteins c-akt; Survival Rate; Young Adult

2019

Other Studies

5 other study(ies) available for perifosine and Brain Neoplasms

ArticleYear
The short chain cell-permeable ceramide (C6) restores cell apoptosis and perifosine sensitivity in cultured glioblastoma cells.
    Molecular biology reports, 2013, Volume: 40, Issue:10

    Topics: Apoptosis; Autophagy; Brain Neoplasms; Cell Membrane Permeability; Cell Proliferation; Cell Survival; Ceramides; Glioblastoma; HEK293 Cells; Humans; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Cells, Cultured

2013
Cholesterol homeostasis and autophagic flux in perifosine-treated human hepatoblastoma HepG2 and glioblastoma U-87 MG cell lines.
    Biochemical pharmacology, 2015, Jul-01, Volume: 96, Issue:1

    Topics: Autophagy; Brain Neoplasms; Cell Line, Tumor; Cholesterol; Glioblastoma; Hepatoblastoma; Homeostasis; Humans; Liver Neoplasms; Phosphorylcholine

2015
Perifosine-induced inhibition of Akt attenuates brain-derived neurotrophic factor/TrkB-induced chemoresistance in neuroblastoma in vivo.
    Cancer, 2011, Dec-01, Volume: 117, Issue:23

    Topics: Brain Neoplasms; Brain-Derived Neurotrophic Factor; Cell Line, Tumor; Drug Resistance, Neoplasm; Etoposide; Humans; Neuroblastoma; Phosphorylation; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Receptor, trkB; Tetracycline

2011
Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo.
    Cancer research, 2005, Aug-15, Volume: 65, Issue:16

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; CDC2-CDC28 Kinases; Cell Growth Processes; Cell Line, Tumor; Cyclin-Dependent Kinase 2; Dacarbazine; Dose-Response Relationship, Drug; Drug Synergism; G1 Phase; G2 Phase; Glioma; Humans; Mice; Mice, Transgenic; Phosphorylcholine; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Temozolomide; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays

2005
Inhibition of Akt by the alkylphospholipid perifosine does not enhance the radiosensitivity of human glioma cells.
    Molecular cancer therapeutics, 2006, Volume: 5, Issue:6

    Topics: Animals; Apoptosis; Brain Neoplasms; Combined Modality Therapy; Female; Glioma; Humans; Immunohistochemistry; Mice; Mice, Nude; Phosphorylation; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Radiation Tolerance; Transplantation, Heterologous; Tumor Cells, Cultured; Tumor Stem Cell Assay

2006