pericosine-b and Neoplasms

pericosine-b has been researched along with Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for pericosine-b and Neoplasms

Article	Year
Pericosines, antitumour metabolites from the sea hare-derived fungus Periconia byssoides. Structures and biological activities. Organic & biomolecular chemistry, 2007, Dec-21, Volume: 5, Issue:24 Pericosines A-E 1-5 have been isolated from a strain of Periconia byssoides originally separated from the sea hare Aplysia kurodai. Among them, pericosines C 3 and E 5 were separated as enantiomeric mixtures. Their stereostructures, except for compound 1, have been elucidated or identified on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, and X-ray analysis. In addition, conformation for all the compounds has been discussed. Compounds 1-3 exhibited significant growth inhibition against tumour cell lines. Pericosine A 1 also showed significant in vivo tumour inhibitory activity. In addition, compound inhibited the protein kinase EGFR and topoisomerase II. Topics: Animals; Aplysia; Ascomycota; Humans; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Neoplasms; Shikimic Acid; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Stereoisomerism; Tumor Cells, Cultured	2007

Article

Year

Pericosines, antitumour metabolites from the sea hare-derived fungus Periconia byssoides. Structures and biological activities.

Organic & biomolecular chemistry, 2007, Dec-21, Volume: 5, Issue:24

Pericosines A-E 1-5 have been isolated from a strain of Periconia byssoides originally separated from the sea hare Aplysia kurodai. Among them, pericosines C 3 and E 5 were separated as enantiomeric mixtures. Their stereostructures, except for compound 1, have been elucidated or identified on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, and X-ray analysis. In addition, conformation for all the compounds has been discussed. Compounds 1-3 exhibited significant growth inhibition against tumour cell lines. Pericosine A 1 also showed significant in vivo tumour inhibitory activity. In addition, compound inhibited the protein kinase EGFR and topoisomerase II.

Topics: Animals; Aplysia; Ascomycota; Humans; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Neoplasms; Shikimic Acid; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Stereoisomerism; Tumor Cells, Cultured

2007