perhexiline has been researched along with Sensitivity and Specificity in 3 studies
Perhexiline: 2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Perhexiline is a drug that is used for treatment of moderate to severe angina pectoris that has not responded to other treatment." | 1.35 | Determination of perhexiline and its metabolite hydroxyperhexiline in human plasma by liquid chromatography/tandem mass spectrometry. ( Barclay, ML; Begg, EJ; Moore, GA; Zhang, M, 2009) |
| "In a prospective study, steady-state plasma concentrations of (+) and (-)-perhexiline were quantified in 10 CYP2D6 genotyped patients following dosing with 100 mg/day rac-perhexiline maleate, and following a subsequent dosage increase to 150 or 200 mg/day." | 1.34 | Effect of CYP2D6 metabolizer status on the disposition of the (+) and (-) enantiomers of perhexiline in patients with myocardial ischaemia. ( Coller, JK; Davies, BJ; Herbert, MK; Horowitz, JD; Inglis, SC; James, HM; Milne, RW; Morris, RG; Sallustio, BC; Somogyi, AA, 2007) |
| " 2) To determine whether the ratio measured in the first fortnight of treatment (C(i)(OHPx)/C(i)(Px)) may be used to guide patient dosing with perhexiline, a drug with a narrow therapeutic index, long half-life and saturable metabolism via CYP2D6." | 1.31 | Pharmacokinetics of the antianginal agent perhexiline: relationship between metabolic ratio and steady-state dose. ( Morris, RG; Sallustio, BC; Westley, IS, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, M | 1 |
| Moore, GA | 1 |
| Barclay, ML | 1 |
| Begg, EJ | 1 |
| Sallustio, BC | 2 |
| Westley, IS | 1 |
| Morris, RG | 2 |
| Inglis, SC | 1 |
| Herbert, MK | 1 |
| Davies, BJ | 1 |
| Coller, JK | 1 |
| James, HM | 1 |
| Horowitz, JD | 1 |
| Milne, RW | 1 |
| Somogyi, AA | 1 |
3 other studies available for perhexiline and Sensitivity and Specificity
| Article | Year |
|---|---|
Determination of perhexiline and its metabolite hydroxyperhexiline in human plasma by liquid chromatography/tandem mass spectrometry.
Topics: Chromatography, Liquid; Doxepin; Humans; Linear Models; Perhexiline; Reproducibility of Results; Sen | 2009 |
Pharmacokinetics of the antianginal agent perhexiline: relationship between metabolic ratio and steady-state dose.
Topics: Angina Pectoris; Biological Availability; Cardiovascular Agents; Chromatography, High Pressure Liqui | 2002 |
Effect of CYP2D6 metabolizer status on the disposition of the (+) and (-) enantiomers of perhexiline in patients with myocardial ischaemia.
Topics: Biological Availability; Cardiovascular Agents; Cytochrome P-450 CYP2D6; Genotype; Humans; Metabolic | 2007 |