Compounds > perhexiline
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perhexiline and Peripheral Nerve Diseases

perhexiline has been researched along with Peripheral Nerve Diseases in 32 studies

Perhexiline: 2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.

Research Excerpts

ExcerptRelevanceReference
"In a 78-year-old woman receiving perhexiline maleate for intractable angina pectoris, a syndrome of parkinsonism and peripheral neuropathy developed."3.66Perhexiline maleate as a cause of reversible parkinsonism and peripheral neuropathy. ( Gordon, AS; Gordon, M, 1981)
"Five patients developed a mild to severe polyneuropathy while under treatment with perhexiline maleate, a drug used in long-term treatment of angina pectoris."3.66Perhexiline neuropathy: a clinicopathological study. ( Said, G, 1978)
"Peripheral neuropathy has been noted as a complication of therapy with perhexiline maleate, a drug widely used in France (and in clinical trials in the United States) for the prophylactic treatment of angina pectoris."3.66Perhexiline maleate and peripheral neuropathy. ( Bouche, P; Bousser, MG; Cathala, HP; Peytour, MA, 1979)
"The pathological findings in four nerves and muscles and in one skin biopsies from four patients treated with perhexiline maleate for angina pectoris are reported."3.65[Electron microscopic study of nerve, muscle and skin lesions induced by perhexiline maleate (author's transl)]. ( Escourolle, R; Hauw, JJ; Mussini, JM, 1977)
"Perhexiline maleate is an amphiphilic molecule."1.27[Study of thesaurismosis induced by perhexiline maleate. Confirmation of experimental data]. ( Albouz, S; Bajolet, A; Baumann, N; Caulet, T; Pluot, M; Turpin, JC, 1983)
"Ten new cases of perhexiline induced peripheral neuropathies are reported."1.26[Neurological disorders and perhexiline maleate therapy. Clinical study of 10 cases. Neuropathological, pharmacocinetic and biochemical studies (author's transl)]. ( Bakouche, P; Baumann, N; Dudognon, P; Ermidou, S; Escourolle, R; Hauw, JJ; Lévy, J; Nick, J; Nicolle, MH; Pollet, S; Reignier, A; Singlas, E, 1978)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199031 (96.88)18.7374
1990's1 (3.13)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Goble, AJ1
Horowitz, JD1
Heathfield, KW1
Carabott, F1
Laplane, D2
Bousser, MG3
Wijesekera, JC1
Critchley, EM1
Fahim, Y1
Lynch, PG1
Wright, JS1
Kanareĭkin, KF1
Babenkova, SV1
Manvelov, LS1
Eskin, MA1
Sax, DS1
Kovacs, ZL1
Johnson, TL1
Feldman, RG1
Gordon, M1
Gordon, AS1
Shah, RR2
Oates, NS2
Idle, JR3
Smith, RL2
Lockhart, JD2
Hauw, JJ6
Mussini, JM2
Boutry, JM1
Escourolle, R5
Pollet, S4
Albouz, S2
Harpin, ML1
Baumann, N5
Turpin, JC2
Pluot, M1
Bajolet, A1
Caulet, T1
Lorentz, IT1
Shortall, M1
Mancaux, A1
Dernier, J1
Colen, A1
Williame, E1
Sebille, A1
Bourrat, C2
Viala, JJ1
Guastala, JP1
Lhermitte, F1
Fardeau, M1
Chedru, F1
Mallecourt, J1
Fraser, DM2
Campbell, IW1
Miller, HC2
Mabin, D1
Penther, P1
Blanc, JJ1
Bouche, P2
Singlas, E3
Touboul, PJ1
Martin, HJ1
Petit, H1
Masingue, M1
Pruvot, J1
Poisson, M2
Tempier, P1
Sichez, JP2
Mashaly, R1
van Effenterre, R1
van Effenterre, G1
Schaison, M1
Haut, J1
Said, G1
Nick, J1
Dudognon, P1
Bakouche, P1
Nicolle, MH1
Reignier, A1
Ermidou, S1
Lévy, J1
Jallon, P1
Loiseau, P1
Orgogozo, JM1
Le Saux, F1
Peytour, MA1
Cathala, HP1
Bady, B1
Trillet, M1
Girard, PF1
Carrier, H1

Reviews

3 reviews available for perhexiline and Peripheral Nerve Diseases

ArticleYear
Polyneuropathy during perhexiline maleate therapy.
    International journal of neurology, 1981, Volume: 15, Issue:3-4

    Topics: Electromyography; Humans; Neural Conduction; Perhexiline; Peripheral Nervous System Diseases; Polyne

1981
[Exogenous toxic polyneuropathies].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1981, Volume: 81, Issue:1

    Topics: Adult; Anti-Bacterial Agents; Antineoplastic Agents; Carbon Disulfide; Carbon Monoxide Poisoning; Fe

1981
[Toxic neurologic manifestations during angina pectoris treatment (perhexiline maleate and amiotadone hydrochloride)].
    International journal of neurology, 1978, Volume: 11, Issue:4

    Topics: Amiodarone; Angina Pectoris; Benzofurans; Cerebrospinal Fluid Proteins; Electromyography; Humans; In

1978

Other Studies

29 other studies available for perhexiline and Peripheral Nerve Diseases

ArticleYear
Perhexilene neuropathy: a report of two cases.
    Australian and New Zealand journal of medicine, 1984, Volume: 14, Issue:3

    Topics: Humans; Perhexiline; Peripheral Nervous System Diseases

1984
Adverse effects of perhexiline.
    Lancet (London, England), 1982, Feb-27, Volume: 1, Issue:8270

    Topics: Adult; Aged; Angina Pectoris; Female; Humans; Liver Cirrhosis; Male; Perhexiline; Peripheral Nervous

1982
Peripheral neuropathy due to perhexilene maleate.
    Journal of the neurological sciences, 1980, Volume: 46, Issue:3

    Topics: Aged; Female; Humans; Male; Middle Aged; Perhexiline; Peripheral Nerves; Peripheral Nervous System D

1980
Clinical applications of the estimation of nerve conduction velocity distributions.
    Progress in clinical and biological research, 1981, Volume: 52

    Topics: Adolescent; Adult; Aged; Aging; Diabetes Mellitus; Electrophysiology; Female; Hexanes; Humans; Lead

1981
Perhexiline maleate as a cause of reversible parkinsonism and peripheral neuropathy.
    Journal of the American Geriatrics Society, 1981, Volume: 29, Issue:6

    Topics: Aged; Angina Pectoris; Female; Humans; Parkinson Disease, Secondary; Perhexiline; Peripheral Nervous

1981
Impaired oxidation of debrisoquine in patients with perhexiline neuropathy.
    British medical journal (Clinical research ed.), 1982, Jan-30, Volume: 284, Issue:6312

    Topics: Adult; Aged; Alcohol Drinking; Angina Pectoris; Debrisoquin; Female; Humans; Isoquinolines; Liver Fu

1982
Perhexiline maleate induced lipidosis in human peripheral nerve and tissue culture: ultrastructural and biochemical changes.
    Clinical toxicology, 1981, Volume: 18, Issue:12

    Topics: Cells, Cultured; Fibroblasts; Humans; Lipidoses; Perhexiline; Peripheral Nerves; Peripheral Nervous

1981
Prediction of subclinical perhexiline neuropathy in a patient with inborn error of debrisoquine hydroxylation.
    American heart journal, 1983, Volume: 105, Issue:1

    Topics: Angina Pectoris; Debrisoquin; Electromyography; Humans; Hydroxylation; Isoquinolines; Male; Middle A

1983
[Study of thesaurismosis induced by perhexiline maleate. Confirmation of experimental data].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1983, Jan-06, Volume: 59, Issue:1

    Topics: Cerebellar Ataxia; Female; Humans; Lipidoses; Middle Aged; Neuromuscular Diseases; Perhexiline; Peri

1983
Perhexilene neuropathy: a report of two cases.
    Australian and New Zealand journal of medicine, 1983, Volume: 13, Issue:5

    Topics: Angina Pectoris; Female; Humans; Leg; Male; Middle Aged; Neural Conduction; Pain; Paresthesia; Perhe

1983
The long and the short of drug safety.
    Lancet (London, England), 1993, Mar-13, Volume: 341, Issue:8846

    Topics: Calcium Channel Blockers; Half-Life; Humans; Perhexiline; Peripheral Nervous System Diseases

1993
[Neuropathies due to perhexiline maleate and their electromyographic diagnosis].
    Journal belge de medecine physique et de rehabilitation. = Belgisch tijdschrift voor fysische geneeskunde en rehabilitatie, 1980, Volume: 3, Issue:1

    Topics: Aged; Electromyography; Humans; Neural Conduction; Paresthesia; Perhexiline; Peripheral Nervous Syst

1980
Peripheral-nerve lipid abnormalities in patients on perhexiline maleate.
    Lancet (London, England), 1977, Jun-11, Volume: 1, Issue:8024

    Topics: Gangliosides; Humans; Maleates; Perhexiline; Peripheral Nerves; Peripheral Nervous System Diseases;

1977
[Electrophysiological study of latent neuropathies induced by perhexiline].
    Electroencephalography and clinical neurophysiology, 1978, Volume: 45, Issue:5

    Topics: Adult; Aged; Angina Pectoris; Electric Stimulation; Evoked Potentials; H-Reflex; Humans; Middle Aged

1978
[Letter: Peripheral neuropathy after prolonged adsorption of perhexiline maleate. 2 cases].
    La Nouvelle presse medicale, 1975, Oct-18, Volume: 4, Issue:35

    Topics: Aged; Angina Pectoris; Humans; Male; Maleates; Paresthesia; Parkinson Disease, Secondary; Perhexilin

1975
Polyneuropathy after perhexiline maleate therapy.
    British medical journal, 1976, May-22, Volume: 1, Issue:6020

    Topics: Humans; Male; Middle Aged; Myocardial Infarction; Perhexiline; Peripheral Nervous System Diseases; P

1976
[Electron microscopic study of nerve, muscle and skin lesions induced by perhexiline maleate (author's transl)].
    Acta neuropathologica, 1977, Apr-29, Volume: 38, Issue:1

    Topics: Aged; Angina Pectoris; Female; Humans; Male; Microscopy, Electron; Middle Aged; Muscles; Muscular At

1977
Peripheral and autonomic neuropathy after treatment with perhexiline maleate.
    British medical journal, 1977, Sep-10, Volume: 2, Issue:6088

    Topics: Autonomic Nervous System; Diabetic Neuropathies; Humans; Male; Middle Aged; Nervous System Diseases;

1977
[Electromyogram and nervous conduction speeds during prolonged treatment by perhexiline maleate (author's transl)].
    Annales de cardiologie et d'angeiologie, 1977, Volume: 26, Issue:5

    Topics: Adult; Aged; Angina Pectoris; Electromyography; Female; Humans; Long-Term Care; Male; Middle Aged; N

1977
[Peripheral neuropathies due to perhexiline maleate (author's transl)].
    Annales de cardiologie et d'angeiologie, 1977, Volume: 26 Suppl

    Topics: Humans; Male; Middle Aged; Perhexiline; Peripheral Nervous System Diseases; Piperidines

1977
[Peripheral neuropathies during treatment with perhexilline maleate (apropos of 10 cases)].
    Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille, 1977, Volume: 22, Issue:9

    Topics: Aged; Female; Humans; Middle Aged; Perhexiline; Peripheral Nervous System Diseases; Piperidines; Tim

1977
[Post-arteriographic thrombosis of the ophthalmic veins in 2 cases of peripheral neuropathy with central neurological signs due to perhexiline maleate].
    La Nouvelle presse medicale, 1977, Nov-12, Volume: 6, Issue:38

    Topics: Cerebral Angiography; Eye; Humans; Neurologic Manifestations; Perhexiline; Peripheral Nervous System

1977
[Oedematous optic neuropathy from Perhexilline maleate associated with peripheral polyneuropathy (author's transl)].
    Archives d'ophtalmologie, 1977, Volume: 37, Issue:11

    Topics: Humans; Intracranial Pressure; Male; Middle Aged; Optic Nerve Diseases; Papilledema; Perhexiline; Pe

1977
Perhexilline-induced neuropathy.
    British medical journal, 1978, Apr-01, Volume: 1, Issue:6116

    Topics: Aged; Autonomic Nervous System; Female; Humans; Male; Middle Aged; Nervous System Diseases; Perhexil

1978
Perhexiline neuropathy: a clinicopathological study.
    Annals of neurology, 1978, Volume: 3, Issue:3

    Topics: Aged; Angina Pectoris; Demyelinating Diseases; Female; Humans; Male; Middle Aged; Nerve Fibers; Perh

1978
[Neurological disorders and perhexiline maleate therapy. Clinical study of 10 cases. Neuropathological, pharmacocinetic and biochemical studies (author's transl)].
    Revue neurologique, 1978, Volume: 134, Issue:2

    Topics: Cerebellar Diseases; Coronary Disease; Demyelinating Diseases; Endothelium; Humans; Inclusion Bodies

1978
Polyneuropathy with normal metabolism of perhexiline maleate.
    Annals of neurology, 1978, Volume: 4, Issue:4

    Topics: Aged; Female; Humans; Perhexiline; Peripheral Nervous System Diseases; Piperidines

1978
Analysis of the major lipid classes in human peripheral nerve biopsies. Age group differences and abnormalities of ganglioside level in perhexiline maleate therapy.
    Journal of the neurological sciences, 1979, Volume: 41, Issue:2

    Topics: Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Gangliosides; Glycolipids; Humans; In

1979
Perhexiline maleate and peripheral neuropathy.
    Neurology, 1979, Volume: 29, Issue:5

    Topics: Adult; Aged; Angina Pectoris; Electromyography; Female; Follow-Up Studies; Humans; Male; Middle Aged

1979