perhexiline has been researched along with Neoplasms in 3 studies
Perhexiline: 2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Perhexiline is a prophylactic antianginal drug known to act by inhibiting carnitine palmitoyltransferase 1 (CPT1) and 2 (CPT2), mitochondrial enzymes critical for fatty acid metabolism." | 3.01 | Perhexiline: Old Drug, New Tricks? A Summary of Its Anti-Cancer Effects. ( Dhakal, B; Drew, P; Fenix, K; Maddern, G; Price, T; Smith, E; Tomita, Y, 2023) |
| "Since Warburg's observation that most cancers exhibit elevated glycolysis, decades of research have attempted to reduce tumor glucose utilization as a therapeutic approach." | 2.61 | A Tumor Agnostic Therapeutic Strategy for Hexokinase 1-Null/Hexokinase 2-Positive Cancers. ( Herschman, HR; Xu, S, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 2 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Dhakal, B | 1 |
| Tomita, Y | 1 |
| Drew, P | 1 |
| Price, T | 1 |
| Maddern, G | 1 |
| Smith, E | 1 |
| Fenix, K | 1 |
| Jiang, S | 1 |
| Fu, W | 1 |
| Wang, S | 1 |
| Zhu, G | 1 |
| Wang, J | 1 |
| Ma, Y | 1 |
| Xu, S | 1 |
| Herschman, HR | 1 |
2 reviews available for perhexiline and Neoplasms
| Article | Year |
|---|---|
Perhexiline: Old Drug, New Tricks? A Summary of Its Anti-Cancer Effects.
Topics: Cardiovascular Agents; Fatty Acids; Humans; Mitochondria; Neoplasms; Perhexiline | 2023 |
A Tumor Agnostic Therapeutic Strategy for Hexokinase 1-Null/Hexokinase 2-Positive Cancers.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Glycolysis; Hexokinase; H | 2019 |
1 other study available for perhexiline and Neoplasms
| Article | Year |
|---|---|
Bacterial Outer Membrane Vesicles Loaded with Perhexiline Suppress Tumor Development by Regulating Tumor-Associated Macrophages Repolarization in a Synergistic Way.
Topics: Bacterial Outer Membrane; Escherichia coli; Humans; Macrophages; Neoplasms; Perhexiline; Tumor-Assoc | 2023 |