perhexiline has been researched along with Liver Diseases in 7 studies
Perhexiline: 2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.
Liver Diseases: Pathological processes of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The entire spectrum of alcoholic liver disease, including alcoholic hepatitis, may be perfectly mimicked by severe obesity, diabetes, and perhexiline maleate toxicity." | 3.67 | Problems in the necropsy diagnosis of alcoholic liver disease. ( Pounder, DJ, 1984) |
| " These products are well absorbed from the gastrointestinal tract but undergo variable degrees of transformation during the first passage through the liver." | 2.37 | [Clinical pharmacology of calcium inhibitors]. ( Martre, H; Singlas, E; Taburet, AM, 1985) |
| "Perhexiline maleate is an antianginal agent which depends on hepatic oxidation for its elimination." | 1.27 | Impaired oxidation of debrisoquine in patients with perhexiline liver injury. ( Morgan, MY; Oates, NS; Reshef, R; Shah, RR; Sherlock, S; Smith, RL, 1984) |
| "Perhexiline maleate is an anti-anginal drug believed to cause liver damage." | 1.26 | The effects of perhexiline maleate (Pexid) and alcohol on rat liver. ( McDonald, GS, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Morgan, MY | 1 |
| Reshef, R | 1 |
| Shah, RR | 1 |
| Oates, NS | 1 |
| Smith, RL | 1 |
| Sherlock, S | 1 |
| Pounder, DJ | 1 |
| Roberts, RK | 1 |
| Cohn, D | 1 |
| Petroff, V | 1 |
| Seneviratne, B | 1 |
| Horowitz, JD | 1 |
| Mashford, ML | 1 |
| McDonald, GS | 1 |
| Forbes, GB | 1 |
| Rake, MO | 1 |
| Taylor, DJ | 1 |
| Singlas, E | 1 |
| Martre, H | 1 |
| Taburet, AM | 1 |
1 review available for perhexiline and Liver Diseases
| Article | Year |
|---|---|
[Clinical pharmacology of calcium inhibitors].
Topics: Age Factors; Animals; Bepridil; Biological Availability; Biotransformation; Calcium Channel Blockers | 1985 |
6 other studies available for perhexiline and Liver Diseases
| Article | Year |
|---|---|
Impaired oxidation of debrisoquine in patients with perhexiline liver injury.
Topics: Adolescent; Adult; Aged; Angina Pectoris; Chemical and Drug Induced Liver Injury; Chronic Disease; D | 1984 |
Problems in the necropsy diagnosis of alcoholic liver disease.
Topics: Acetaminophen; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Diabetes Mellitus; D | 1984 |
Liver disease induced by perhexiline maleate.
Topics: Angina Pectoris; Chemical and Drug Induced Liver Injury; Humans; Liver; Liver Cirrhosis, Alcoholic; | 1981 |
Long-term safety of perhexiline maleate.
Topics: Angina Pectoris; Body Weight; Humans; Liver Diseases; Neuromuscular Diseases; Perhexiline; Piperidin | 1979 |
The effects of perhexiline maleate (Pexid) and alcohol on rat liver.
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Synergism; Ethanol; Liver; Liver Diseases; Mal | 1979 |
Liver damage due to perhexiline maleate.
Topics: Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Hepatitis, Alcoholic; Humans; Liver | 1979 |