perhexiline has been researched along with Lipidoses in 13 studies
Perhexiline: 2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.
Lipidoses: Conditions characterized by abnormal lipid deposition due to disturbance in lipid metabolism, such as hereditary diseases involving lysosomal enzymes required for lipid breakdown. They are classified either by the enzyme defect or by the type of lipid involved.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Case report of polyneuritis and liver dysfunction induced by perhexiline maleate in a 64 years old male patient." | 3.66 | [Diffuse polymorphous inclusions in a patient treated with perhexiline maleate (author's transl)]. ( de Saint-Maur, PP; Hauw, JJ; Lageron, A; Lecomte, D; Pollet, S; Poupon, R; Singer, B, 1978) |
| "Phospholipidosis (PLD) is a lysosomal storage disorder induced by compounds, notably cationic amphiphilic drugs, which although reversible interferes with cellular phospholipids." | 1.38 | In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets. ( Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T, 2012) |
| "Phospholipidosis is an adverse effect caused by numerous cationic amphiphilic drugs and can affect many cell types." | 1.36 | Predicting phospholipidosis using machine learning. ( Glen, RC; Lowe, R; Mitchell, JB, 2010) |
| "Perhexiline maleate is an amphiphilic molecule." | 1.27 | [Study of thesaurismosis induced by perhexiline maleate. Confirmation of experimental data]. ( Albouz, S; Bajolet, A; Baumann, N; Caulet, T; Pluot, M; Turpin, JC, 1983) |
| "Perhexiline maleate, an antianginal compound, may cause severe adverse effects such as weight loss, hepatic dysfunction and peripheral neuropathy in a small proportion of patients." | 1.27 | Perhexiline-induced lipidosis in the dark Agouti (DA) rat. An animal model of genetically determined neurotoxicity. ( Hess, CW; Meier, C; Preisig, R; Wahllaender, A, 1986) |
| "Drug induced lipidosis may involve other lipids than phospholipids, particularly gangliosides." | 1.26 | Perhexiline maleate-induced lipidosis in cultured human fibroblasts: cell kinetics, ultrastructural and biochemical studies. ( Albouz, S; Baudrimont, M; Baumann, N; Boutry, JM; Escourolle, R; Harpin, ML; Hauw, JJ, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (76.92) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lowe, R | 1 |
| Glen, RC | 1 |
| Mitchell, JB | 1 |
| Fischer, H | 1 |
| Atzpodien, EA | 1 |
| Csato, M | 1 |
| Doessegger, L | 1 |
| Lenz, B | 1 |
| Schmitt, G | 1 |
| Singer, T | 1 |
| Hauw, JJ | 4 |
| Boutry, JM | 3 |
| Albouz, S | 3 |
| Harpin, ML | 2 |
| Baudrimont, M | 1 |
| Escourolle, R | 3 |
| Baumann, N | 3 |
| Mussini, JM | 1 |
| Pollet, S | 2 |
| Turpin, JC | 1 |
| Pluot, M | 1 |
| Bajolet, A | 1 |
| Caulet, T | 1 |
| Albert, C | 1 |
| Lüllmann-Rauch, R | 4 |
| Frisch, W | 1 |
| Hamam, S | 1 |
| Lüllmann, H | 1 |
| Singer, B | 1 |
| Poupon, R | 1 |
| Lecomte, D | 1 |
| de Saint-Maur, PP | 1 |
| Lageron, A | 1 |
| Jaffrézou, JP | 1 |
| Levade, T | 1 |
| Thurneyssen, O | 1 |
| Chiron, M | 1 |
| Bordier, C | 1 |
| Attal, M | 1 |
| Chatelain, P | 1 |
| Laurent, G | 1 |
| Meier, C | 1 |
| Wahllaender, A | 1 |
| Hess, CW | 1 |
| Preisig, R | 1 |
1 review available for perhexiline and Lipidoses
| Article | Year |
|---|---|
Experimentally induced lipidosis in rat retinal pigment epithelium. A brief review.
Topics: Amiodarone; Animals; Chloroquine; Chlorphentermine; Imipramine; Lipidoses; Microscopy, Electron; Per | 1981 |
12 other studies available for perhexiline and Lipidoses
| Article | Year |
|---|---|
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Bio | 2010 |
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets.
Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse | 2012 |
Perhexiline maleate-induced lipidosis in cultured human fibroblasts: cell kinetics, ultrastructural and biochemical studies.
Topics: Cell Division; Cell Survival; Cells, Cultured; Cholesterol; Fibroblasts; Gangliosides; Humans; Kinet | 1980 |
Perhexiline maleate induced lipidosis in human peripheral nerve and tissue culture: ultrastructural and biochemical changes.
Topics: Cells, Cultured; Fibroblasts; Humans; Lipidoses; Perhexiline; Peripheral Nerves; Peripheral Nervous | 1981 |
[Study of thesaurismosis induced by perhexiline maleate. Confirmation of experimental data].
Topics: Cerebellar Ataxia; Female; Humans; Lipidoses; Middle Aged; Neuromuscular Diseases; Perhexiline; Peri | 1983 |
Ultrastructural alterations in peripheral nerve trunks of rats subchronically treated with chlorphentermine or perhexiline.
Topics: Animals; Chlorphentermine; Female; Lipidoses; Male; Perhexiline; Peripheral Nerves; Phentermine; Pip | 1983 |
Effects of several lipidosis-including drugs upon the area postrema and adjacent medullary nuclei of adult rats. I. Alterations is perikarya and dendrites.
Topics: Animals; Blood-Brain Barrier; Brain Diseases; Chloroquine; Chlorphentermine; Female; Lipidoses; Male | 1980 |
[Perhexiline-maleate-induced lipidosis in mouse spinal ganglia tissue culture. Preliminary results on the acute toxicity on the drug].
Topics: Animals; Culture Techniques; Ganglia, Spinal; Lipidoses; Mice; Microscopy, Electron; Perhexiline; Pi | 1978 |
Perhexiline induces generalized lipidosis in rats.
Topics: Animals; Inclusion Bodies; Lipidoses; Perhexiline; Piperidines; Rats | 1978 |
[Diffuse polymorphous inclusions in a patient treated with perhexiline maleate (author's transl)].
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Humans; Inclusion Bodies; Lipidoses; Liver; Male; Mi | 1978 |
In vitro and in vivo enhancement of ricin-A chain immunotoxin activity by novel indolizine calcium channel blockers: delayed intracellular degradation linked to lipidosis induction.
Topics: Ammonium Chloride; Antibodies, Monoclonal; Dose-Response Relationship, Drug; Drug Synergism; Humans; | 1992 |
Perhexiline-induced lipidosis in the dark Agouti (DA) rat. An animal model of genetically determined neurotoxicity.
Topics: Animals; Ganglia, Spinal; Ganglia, Sympathetic; Lipidoses; Models, Biological; Perhexiline; Rats; Sp | 1986 |