Page last updated: 2024-11-02

perhexiline and Lipidoses

perhexiline has been researched along with Lipidoses in 13 studies

Perhexiline: 2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.

Lipidoses: Conditions characterized by abnormal lipid deposition due to disturbance in lipid metabolism, such as hereditary diseases involving lysosomal enzymes required for lipid breakdown. They are classified either by the enzyme defect or by the type of lipid involved.

Research Excerpts

ExcerptRelevanceReference
"Case report of polyneuritis and liver dysfunction induced by perhexiline maleate in a 64 years old male patient."3.66[Diffuse polymorphous inclusions in a patient treated with perhexiline maleate (author's transl)]. ( de Saint-Maur, PP; Hauw, JJ; Lageron, A; Lecomte, D; Pollet, S; Poupon, R; Singer, B, 1978)
"Phospholipidosis (PLD) is a lysosomal storage disorder induced by compounds, notably cationic amphiphilic drugs, which although reversible interferes with cellular phospholipids."1.38In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets. ( Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T, 2012)
"Phospholipidosis is an adverse effect caused by numerous cationic amphiphilic drugs and can affect many cell types."1.36Predicting phospholipidosis using machine learning. ( Glen, RC; Lowe, R; Mitchell, JB, 2010)
"Perhexiline maleate is an amphiphilic molecule."1.27[Study of thesaurismosis induced by perhexiline maleate. Confirmation of experimental data]. ( Albouz, S; Bajolet, A; Baumann, N; Caulet, T; Pluot, M; Turpin, JC, 1983)
"Perhexiline maleate, an antianginal compound, may cause severe adverse effects such as weight loss, hepatic dysfunction and peripheral neuropathy in a small proportion of patients."1.27Perhexiline-induced lipidosis in the dark Agouti (DA) rat. An animal model of genetically determined neurotoxicity. ( Hess, CW; Meier, C; Preisig, R; Wahllaender, A, 1986)
"Drug induced lipidosis may involve other lipids than phospholipids, particularly gangliosides."1.26Perhexiline maleate-induced lipidosis in cultured human fibroblasts: cell kinetics, ultrastructural and biochemical studies. ( Albouz, S; Baudrimont, M; Baumann, N; Boutry, JM; Escourolle, R; Harpin, ML; Hauw, JJ, 1980)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-199010 (76.92)18.7374
1990's1 (7.69)18.2507
2000's0 (0.00)29.6817
2010's2 (15.38)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lowe, R1
Glen, RC1
Mitchell, JB1
Fischer, H1
Atzpodien, EA1
Csato, M1
Doessegger, L1
Lenz, B1
Schmitt, G1
Singer, T1
Hauw, JJ4
Boutry, JM3
Albouz, S3
Harpin, ML2
Baudrimont, M1
Escourolle, R3
Baumann, N3
Mussini, JM1
Pollet, S2
Turpin, JC1
Pluot, M1
Bajolet, A1
Caulet, T1
Albert, C1
Lüllmann-Rauch, R4
Frisch, W1
Hamam, S1
Lüllmann, H1
Singer, B1
Poupon, R1
Lecomte, D1
de Saint-Maur, PP1
Lageron, A1
Jaffrézou, JP1
Levade, T1
Thurneyssen, O1
Chiron, M1
Bordier, C1
Attal, M1
Chatelain, P1
Laurent, G1
Meier, C1
Wahllaender, A1
Hess, CW1
Preisig, R1

Reviews

1 review available for perhexiline and Lipidoses

ArticleYear
Experimentally induced lipidosis in rat retinal pigment epithelium. A brief review.
    Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology, 1981, Volume: 215, Issue:4

    Topics: Amiodarone; Animals; Chloroquine; Chlorphentermine; Imipramine; Lipidoses; Microscopy, Electron; Per

1981

Other Studies

12 other studies available for perhexiline and Lipidoses

ArticleYear
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Bio

2010
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets.
    Journal of medicinal chemistry, 2012, Jan-12, Volume: 55, Issue:1

    Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse

2012
Perhexiline maleate-induced lipidosis in cultured human fibroblasts: cell kinetics, ultrastructural and biochemical studies.
    Virchows Archiv. B, Cell pathology including molecular pathology, 1980, Volume: 34, Issue:3

    Topics: Cell Division; Cell Survival; Cells, Cultured; Cholesterol; Fibroblasts; Gangliosides; Humans; Kinet

1980
Perhexiline maleate induced lipidosis in human peripheral nerve and tissue culture: ultrastructural and biochemical changes.
    Clinical toxicology, 1981, Volume: 18, Issue:12

    Topics: Cells, Cultured; Fibroblasts; Humans; Lipidoses; Perhexiline; Peripheral Nerves; Peripheral Nervous

1981
[Study of thesaurismosis induced by perhexiline maleate. Confirmation of experimental data].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1983, Jan-06, Volume: 59, Issue:1

    Topics: Cerebellar Ataxia; Female; Humans; Lipidoses; Middle Aged; Neuromuscular Diseases; Perhexiline; Peri

1983
Ultrastructural alterations in peripheral nerve trunks of rats subchronically treated with chlorphentermine or perhexiline.
    Arzneimittel-Forschung, 1983, Volume: 33, Issue:1

    Topics: Animals; Chlorphentermine; Female; Lipidoses; Male; Perhexiline; Peripheral Nerves; Phentermine; Pip

1983
Effects of several lipidosis-including drugs upon the area postrema and adjacent medullary nuclei of adult rats. I. Alterations is perikarya and dendrites.
    Acta neuropathologica, 1980, Volume: 52, Issue:3

    Topics: Animals; Blood-Brain Barrier; Brain Diseases; Chloroquine; Chlorphentermine; Female; Lipidoses; Male

1980
[Perhexiline-maleate-induced lipidosis in mouse spinal ganglia tissue culture. Preliminary results on the acute toxicity on the drug].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1978, Oct-23, Volume: 287, Issue:10

    Topics: Animals; Culture Techniques; Ganglia, Spinal; Lipidoses; Mice; Microscopy, Electron; Perhexiline; Pi

1978
Perhexiline induces generalized lipidosis in rats.
    Klinische Wochenschrift, 1978, Mar-15, Volume: 56, Issue:6

    Topics: Animals; Inclusion Bodies; Lipidoses; Perhexiline; Piperidines; Rats

1978
[Diffuse polymorphous inclusions in a patient treated with perhexiline maleate (author's transl)].
    La Nouvelle presse medicale, 1978, Mar-11, Volume: 7, Issue:10

    Topics: Biopsy; Chemical and Drug Induced Liver Injury; Humans; Inclusion Bodies; Lipidoses; Liver; Male; Mi

1978
In vitro and in vivo enhancement of ricin-A chain immunotoxin activity by novel indolizine calcium channel blockers: delayed intracellular degradation linked to lipidosis induction.
    Cancer research, 1992, Mar-01, Volume: 52, Issue:5

    Topics: Ammonium Chloride; Antibodies, Monoclonal; Dose-Response Relationship, Drug; Drug Synergism; Humans;

1992
Perhexiline-induced lipidosis in the dark Agouti (DA) rat. An animal model of genetically determined neurotoxicity.
    Brain : a journal of neurology, 1986, Volume: 109 ( Pt 4)

    Topics: Animals; Ganglia, Spinal; Ganglia, Sympathetic; Lipidoses; Models, Biological; Perhexiline; Rats; Sp

1986