perhexiline has been researched along with Fatty Liver in 4 studies
Perhexiline: 2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.
Fatty Liver: Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Drug-induced steatohepatitis is a rare form of liver injury known to be caused by only a handful of compounds." | 2.52 | Mechanistic review of drug-induced steatohepatitis. ( Guo, GL; Schumacher, JD, 2015) |
| "Nonalcoholic steatohepatitis (NASH) is defined histopathologically by the presence of macrovesicular steatosis, cellular ballooning, and inflammation." | 2.48 | A myriad of pathways to NASH. ( Larrain, S; Rinella, ME, 2012) |
| "Drugs rarely cause steatohepatitis, but amiodarone, perhexiline, and DH, have unequivocally been found to independently induce the histologic picture of alcoholic liver disease or NASH." | 2.42 | Drug-induced steatohepatitis. ( Sanyal, AJ; Stravitz, RT, 2003) |
| "In conclusion, steatohepatitis-inducing drugs increase cell calcium and activate tissue transglutaminase, which cross-links CK8 to form a molecular scaffold, from which MDB might secondarily arise." | 1.35 | Steatohepatitis-inducing drugs trigger cytokeratin cross-links in hepatocytes. Possible contribution to Mallory-Denk body formation. ( Berson, A; Descatoire, V; Pessayre, D; Robin, MA, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schumacher, JD | 1 |
| Guo, GL | 1 |
| Robin, MA | 1 |
| Descatoire, V | 1 |
| Pessayre, D | 1 |
| Berson, A | 1 |
| Larrain, S | 1 |
| Rinella, ME | 1 |
| Stravitz, RT | 1 |
| Sanyal, AJ | 1 |
3 reviews available for perhexiline and Fatty Liver
| Article | Year |
|---|---|
Mechanistic review of drug-induced steatohepatitis.
Topics: Amiodarone; Animals; Camptothecin; Chemical and Drug Induced Liver Injury; Disease Models, Animal; F | 2015 |
A myriad of pathways to NASH.
Topics: Amiodarone; Anti-Retroviral Agents; Bacterial Infections; Cannabis; Diet; Fatty Liver; Genetic Disea | 2012 |
Drug-induced steatohepatitis.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Antineoplastic Agents, Hormonal; Calcium Channel Blocke | 2003 |
1 other study available for perhexiline and Fatty Liver
| Article | Year |
|---|---|
Steatohepatitis-inducing drugs trigger cytokeratin cross-links in hepatocytes. Possible contribution to Mallory-Denk body formation.
Topics: Amiodarone; Animals; Calcium; Fatty Liver; GTP-Binding Proteins; Hepatocytes; Hexestrol; Inclusion B | 2008 |