perhexiline has been researched along with Disease Models, Animal in 9 studies
Perhexiline: 2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The novel approach used here led to the discovery that perhexiline ablates HER3 expression, and offers an opportunity to identify HER3 ablation modulators as innovative therapeutics to improve survival in breast cancer patients." | 3.81 | Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth. ( Barak, LS; Chen, W; Lyerly, HK; Mook, RA; Morse, MA; Osada, T; Ren, XR; Wang, J, 2015) |
| "Drug-induced steatohepatitis is a rare form of liver injury known to be caused by only a handful of compounds." | 2.52 | Mechanistic review of drug-induced steatohepatitis. ( Guo, GL; Schumacher, JD, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Gehmlich, K | 1 |
| Dodd, MS | 1 |
| Allwood, JW | 1 |
| Kelly, M | 1 |
| Bellahcene, M | 1 |
| Lad, HV | 1 |
| Stockenhuber, A | 1 |
| Hooper, C | 1 |
| Ashrafian, H | 1 |
| Redwood, CS | 1 |
| Carrier, L | 1 |
| Dunn, WB | 1 |
| Ren, XR | 1 |
| Wang, J | 1 |
| Osada, T | 1 |
| Mook, RA | 1 |
| Morse, MA | 1 |
| Barak, LS | 1 |
| Lyerly, HK | 1 |
| Chen, W | 1 |
| Schumacher, JD | 1 |
| Guo, GL | 1 |
| Liu, PP | 1 |
| Liu, J | 1 |
| Jiang, WQ | 1 |
| Carew, JS | 1 |
| Ogasawara, MA | 1 |
| Pelicano, H | 1 |
| Croce, CM | 1 |
| Estrov, Z | 1 |
| Xu, RH | 1 |
| Keating, MJ | 1 |
| Huang, P | 1 |
| Guidi, A | 1 |
| Lalli, C | 1 |
| Perlas, E | 1 |
| Bolasco, G | 1 |
| Nibbio, M | 1 |
| Monteagudo, E | 1 |
| Bresciani, A | 1 |
| Ruberti, G | 1 |
| Seth, SD | 1 |
| Gupta, MP | 1 |
| Kaur, AH | 1 |
| Basu, AK | 1 |
| Lee, RJ | 1 |
| Silver, PJ | 1 |
| Monteforte, PB | 1 |
1 review available for perhexiline and Disease Models, Animal
| Article | Year |
|---|---|
Mechanistic review of drug-induced steatohepatitis.
Topics: Amiodarone; Animals; Camptothecin; Chemical and Drug Induced Liver Injury; Disease Models, Animal; F | 2015 |
8 other studies available for perhexiline and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Changes in the cardiac metabolome caused by perhexiline treatment in a mouse model of hypertrophic cardiomyopathy.
Topics: Animals; Cardiomyopathy, Hypertrophic; Chromatography, High Pressure Liquid; Disease Models, Animal; | 2015 |
Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Membrane; Cell Proliferatio | 2015 |
Elimination of chronic lymphocytic leukemia cells in stromal microenvironment by targeting CPT with an antiangina drug perhexiline.
Topics: Animals; Antineoplastic Agents; Cardiolipins; Carnitine O-Palmitoyltransferase; Cell Line; Cell Surv | 2016 |
Discovery and Characterization of Novel Anti-schistosomal Properties of the Anti-anginal Drug, Perhexiline and Its Impact on Schistosoma mansoni Male and Female Reproductive Systems.
Topics: Animals; Disease Models, Animal; Drug Resistance; Female; Genitalia; Half-Life; Humans; Life Cycle S | 2016 |
Effect of perhexilene on 86Rb uptake in experimental myocardial infarction.
Topics: Animals; Biological Transport, Active; Disease Models, Animal; Female; Heart; Isoproterenol; Male; M | 1981 |
Effect of chronic administration of perhexiline on pacing-induce S-T segment depression in the atherosclerotic rabbit.
Topics: Angina Pectoris; Animals; Arteriosclerosis; Disease Models, Animal; Electrocardiography; Heart Rate; | 1976 |
Differential effects of pharmacological modulators of cardiac myofibrillar ATPase activity in normal and myopathic (BIO 14.6) hamsters.
Topics: Adenosine Triphosphatases; Animals; Anti-Arrhythmia Agents; Bepridil; Calcium; Calcium Channel Block | 1988 |