perhexiline has been researched along with Coronary Heart Disease in 43 studies
Perhexiline: 2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine whether the prophylactic antianginal agent perhexiline potentiates platelet responsiveness to nitric oxide (NO) in patients with stable angina pectoris (SAP) and acute coronary syndromes (ACS: unstable angina pectoris or non-Q-wave myocardial infarction)." | 9.10 | Beneficial clinical effects of perhexiline in patients with stable angina pectoris and acute coronary syndromes are associated with potentiation of platelet responsiveness to nitric oxide. ( Chirkov, YY; Holmes, AS; Horowitz, JD; Kennedy, JA; Stewart, S; Willoughby, SR, 2002) |
| "The effects of low-dose perhexiline on the exercise training response of 22 male patients, 14 after myocardial infarction and 8 after coronary artery bypass who underwent exercise training, were examined." | 9.05 | Perhexiline during exercise training in coronary heart disease. ( Darby, JF; Ennis, JT; Horgan, JH; Kelly, JG; Teo, KK, 1983) |
| "To examine whether the prophylactic antianginal agent perhexiline potentiates platelet responsiveness to nitric oxide (NO) in patients with stable angina pectoris (SAP) and acute coronary syndromes (ACS: unstable angina pectoris or non-Q-wave myocardial infarction)." | 5.10 | Beneficial clinical effects of perhexiline in patients with stable angina pectoris and acute coronary syndromes are associated with potentiation of platelet responsiveness to nitric oxide. ( Chirkov, YY; Holmes, AS; Horowitz, JD; Kennedy, JA; Stewart, S; Willoughby, SR, 2002) |
| "The effects of low-dose perhexiline on the exercise training response of 22 male patients, 14 after myocardial infarction and 8 after coronary artery bypass who underwent exercise training, were examined." | 5.05 | Perhexiline during exercise training in coronary heart disease. ( Darby, JF; Ennis, JT; Horgan, JH; Kelly, JG; Teo, KK, 1983) |
| "In a preliminary study which lasted 14 weeks, an anti-anginal preparation, perhexiline maleate (Pexid), was prescribed in a dosage of 200 mg twice a day to 7 patients who were suffering from cardiac arrhythmias associated with ischaemic heart disease." | 3.65 | The anti-arrhythmic effects of perhexiline maleate in patients with ischaemic heart disease. ( Gitlin, N, 1975) |
| "Perhexiline is a prophylactic anti-anginal agent that ameliorates the metabolic basis for myocardial ischaemia and is increasingly used in the management of acute coronary syndromes." | 1.32 | Development of a regimen for rapid initiation of perhexiline therapy in acute coronary syndromes. ( Chandy, S; Horowitz, JD; Morris, R; Philpott, A, 2004) |
| "Ten new cases of perhexiline induced peripheral neuropathies are reported." | 1.26 | [Neurological disorders and perhexiline maleate therapy. Clinical study of 10 cases. Neuropathological, pharmacocinetic and biochemical studies (author's transl)]. ( Bakouche, P; Baumann, N; Dudognon, P; Ermidou, S; Escourolle, R; Hauw, JJ; Lévy, J; Nick, J; Nicolle, MH; Pollet, S; Reignier, A; Singlas, E, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 39 (90.70) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (9.30) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Willoughby, SR | 1 |
| Stewart, S | 1 |
| Chirkov, YY | 1 |
| Kennedy, JA | 1 |
| Holmes, AS | 1 |
| Horowitz, JD | 2 |
| Philpott, A | 1 |
| Chandy, S | 1 |
| Morris, R | 1 |
| Celik, T | 1 |
| Kursaklioglu, H | 1 |
| Iyisoy, A | 1 |
| Jata, B | 1 |
| Marazzi, G | 1 |
| Volterrani, M | 1 |
| Rosano, GM | 1 |
| Teo, KK | 1 |
| Kelly, JG | 1 |
| Darby, JF | 1 |
| Ennis, JT | 1 |
| Horgan, JH | 1 |
| Hopf, R | 1 |
| Becker, HJ | 1 |
| Kober, G | 1 |
| Dowinsky, S | 1 |
| Kaltenbach, M | 2 |
| Lehmann, HU | 1 |
| Hochrein, H | 1 |
| Anderes, U | 1 |
| Dieterich, HA | 1 |
| Follath, F | 1 |
| Burkart, F | 1 |
| Witchitz, S | 1 |
| Weber, S | 1 |
| Arich, C | 1 |
| Gitlin, N | 1 |
| Luxereau, PH | 1 |
| Acar, J | 1 |
| Lageron, A | 2 |
| Poupon, R | 2 |
| de Saint-Maur, PP | 1 |
| Lévy, VG | 2 |
| Houdent, CE | 1 |
| Wolf, LM | 1 |
| Corriat, A | 1 |
| Pouget-Abadie, JF | 1 |
| Becq-Giraudon, B | 1 |
| Gil, R | 1 |
| Marin, J | 2 |
| Sudre, Y | 1 |
| Nick, J | 1 |
| Dudognon, P | 1 |
| Escourolle, R | 1 |
| Bakouche, P | 1 |
| Nicolle, MH | 1 |
| Reignier, A | 1 |
| Hauw, JJ | 1 |
| Ermidou, S | 1 |
| Pollet, S | 1 |
| Baumann, N | 1 |
| Singlas, E | 1 |
| Lévy, J | 1 |
| Dernier, J | 1 |
| Colen, A | 1 |
| Bozza, A | 1 |
| de Britto, AH | 1 |
| Malagrino, A | 1 |
| Nogueira, A | 1 |
| Besen, D | 1 |
| Santos, DV | 1 |
| Di Piero, EF | 1 |
| Ferreira, FM | 1 |
| Gomes, FJ | 1 |
| de Brito, FS | 1 |
| Dohmann, H | 1 |
| Arroyo, JB | 1 |
| Batlouni, M | 1 |
| Wagner, M | 1 |
| Studart, PC | 1 |
| Duprat, R | 1 |
| Federico, W | 1 |
| De'Thomatis, M | 1 |
| Falciola, N | 1 |
| Gallesio, R | 1 |
| Ferlemann, HJ | 1 |
| Krehan, L | 1 |
| Adamska-Dyniewska, H | 2 |
| Dziekański, S | 2 |
| Candau, LA | 1 |
| Padilha, JC | 1 |
| Tasca, R | 1 |
| de Patta, M | 1 |
| Weiskopf, JS | 1 |
| Scherr, C | 1 |
| Beaugrand, M | 1 |
| Callard, P | 1 |
| Lecomte, D | 1 |
| Darnis, F | 1 |
| Ferrier, JP | 1 |
| Detilleux, JM | 1 |
| Rausin, G | 1 |
| Albanese, MC | 1 |
| Feruglio, GA | 1 |
| Masoni, A | 1 |
| Tomasi, AM | 1 |
| Oriani, GA | 1 |
| Caponnetto, S | 1 |
| Iannetti, M | 1 |
| Pastorini, C | 1 |
| Masperone, MA | 1 |
| Perugini, P | 1 |
| Oriani, G | 2 |
| Bala, T | 1 |
| Atta, W | 1 |
| Grand, A | 2 |
| Sepulchre, P | 2 |
| Roche, P | 1 |
| Finzi, C | 1 |
| Fischer, DM | 1 |
| Casanova, R | 1 |
| Cornacchia, D | 1 |
| Jacopi, F | 1 |
| Klassen, GA | 1 |
| Sestier, F | 1 |
| L'Abbate, A | 1 |
| Mildenberger, RR | 1 |
| Zborowska-Sluis, DT | 1 |
| Daniell, HB | 1 |
| Dettori, AG | 1 |
| Malagnino, G | 1 |
| Fatti, F | 1 |
| Hamdan, G | 1 |
| Gomez, EA | 1 |
| Vargas, G | 1 |
| Ramirez, MA | 1 |
| Fleury, G | 1 |
| Massabie, R | 1 |
| Cawein, MJ | 1 |
| Lewis, RE | 1 |
| Hudak, WJ | 1 |
| Hoekenga, MT | 1 |
| Newberne, JW | 1 |
| Sukerman, M | 1 |
| Barraine, R | 1 |
| Demange, J | 1 |
| Fayard, JM | 1 |
| Gay, J | 1 |
| Ourbak, P | 1 |
| Queste, M | 1 |
| Maurice, P | 1 |
| Abaza, A | 1 |
| Cattan, D | 1 |
| Aziza, C | 1 |
| Pappo, E | 1 |
3 reviews available for perhexiline and Coronary Heart Disease
| Article | Year |
|---|---|
[Treatment of angina pectoris with calcium antagonists].
Topics: Angina Pectoris; Calcium Channel Blockers; Coronary Disease; Diltiazem; Drug Therapy, Combination; E | 1982 |
[Indications for use of calcium antagonists].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Cardiotonic Agents; Coronary Disease | 1980 |
[Medical therapy of chronic coronary insufficiency].
Topics: Amiodarone; Angina Pectoris; Chronic Disease; Coronary Disease; Digitalis Glycosides; Humans; Lidofl | 1978 |
13 trials available for perhexiline and Coronary Heart Disease
| Article | Year |
|---|---|
Beneficial clinical effects of perhexiline in patients with stable angina pectoris and acute coronary syndromes are associated with potentiation of platelet responsiveness to nitric oxide.
Topics: Aged; Angina Pectoris; Blood Platelets; Cardiovascular Agents; Coronary Disease; Cyclic GMP; Female; | 2002 |
Perhexiline during exercise training in coronary heart disease.
Topics: Coronary Disease; Heart Function Tests; Heart Rate; Humans; Liver Function Tests; Male; Middle Aged; | 1983 |
[Anti-arrhythmic effect of perhexiline].
Topics: Aged; Anti-Arrhythmia Agents; Clinical Trials as Topic; Coronary Disease; Double-Blind Method; Femal | 1981 |
[Perhexiline maleate in a multicentric study in Brazil - a new model of a clinical protocol and mechanism of action of the drug].
Topics: Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Humans; Perhexiline; Physical Exertion; | 1979 |
[Influence of perhexilinmaleat on the exercise electrocardiogram (author's transl)].
Topics: Coronary Disease; Electrocardiography; Heart Rate; Humans; Liver; Male; Perhexiline; Physical Exerti | 1979 |
Clinical evaluation of perhexiline maleate in the treatment of patients with chronic coronary insufficiency.
Topics: Administration, Oral; Aged; Alanine Transaminase; Angina Pectoris; Animals; Arrhythmias, Cardiac; As | 1975 |
Proceedings: Perhexiline versus prenylamine. A controlled clinical trial in coronary insufficiency.
Topics: Adult; Aged; Clinical Trials as Topic; Coronary Disease; Female; Humans; Male; Middle Aged; Nitrogly | 1973 |
Proceedings: Experience with the use of perhexiline in patients with chronic coronary insufficiency: preliminary report.
Topics: Aged; Clinical Trials as Topic; Coronary Disease; Female; Humans; Male; Middle Aged; Nitroglycerin; | 1973 |
Proceedings: Clinical evaluation of perhexiline maleate in patients with angina pectoris associated with a positive coronary artery disease index.
Topics: Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Female; Humans; Male; Perhexiline; Pipe | 1973 |
Proceedings: Assessment of safety data from patients on short and long-term perhexiline therapy.
Topics: Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Enzyme Induction; Enzymes; Humans; Perh | 1973 |
Proceedings: Clinical evaluation of perhexiline maleate in the treatment of chronic cardiac arrhythmias of patients with coronary heart disease.
Topics: Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Coronary Disease; Electrocardiography; Female; | 1973 |
[Study of perhexiline maleate in the treatment of severe chronic coronary insufficiency].
Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Female; Humans; Male; Male | 1974 |
[New treatment in coronary insufficiency: perhexiline maleate].
Topics: Adult; Aged; Coronary Disease; Electrocardiography; Female; Humans; Male; Middle Aged; Perhexiline; | 1973 |
27 other studies available for perhexiline and Coronary Heart Disease
| Article | Year |
|---|---|
Development of a regimen for rapid initiation of perhexiline therapy in acute coronary syndromes.
Topics: Adult; Cardiovascular Agents; Coronary Disease; Drug Administration Schedule; Drug Overdose; Female; | 2004 |
Metabolic agents in the management of diabetic coronary patients: a new era.
Topics: Carnitine; Coronary Disease; Diabetes Mellitus; Diabetic Angiopathies; Dichloroacetic Acid; Enzyme I | 2008 |
Metabolic agents in the management of diabetic coronary patients: a new era.
Topics: Acetanilides; Citric Acid Cycle; Coronary Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; | 2008 |
[Drug therapy of chronic coronary insufficiency].
Topics: Adrenergic beta-Antagonists; Anticoagulants; Coronary Circulation; Coronary Disease; Humans; Oxygen | 1977 |
[Perhexilinemaleate--a new monodrug in the field of coronary therapeutic agents].
Topics: Angina Pectoris; Cardiac Complexes, Premature; Congresses as Topic; Coronary Disease; Germany, West; | 1975 |
The anti-arrhythmic effects of perhexiline maleate in patients with ischaemic heart disease.
Topics: Arrhythmias, Cardiac; Atrial Fibrillation; Cardiac Complexes, Premature; Coronary Disease; Female; H | 1975 |
[Letter: Perhexilinemaleate in patients suffering from chronic coronary failure].
Topics: Adult; Aged; Chronic Disease; Coronary Disease; Drug Tolerance; Female; Humans; Male; Maleates; Midd | 1976 |
Liver ganglioside storage after perhexiline maleate.
Topics: Aged; Chemical and Drug Induced Liver Injury; Coronary Disease; Cytoplasm; Gangliosides; Gangliosido | 1977 |
Liver during perhexiline hypoglycaemia.
Topics: Coronary Disease; Female; Glucose-6-Phosphatase; Humans; Hypoglycemia; Liver; Liver Glycogen; Middle | 1977 |
[A case of polyradiculoneuritis following prolonged treatment with perhexiline maleate].
Topics: Coronary Disease; Female; Humans; Long-Term Care; Middle Aged; Perhexiline; Piperidines; Polyradicul | 1976 |
[Neurological disorders and perhexiline maleate therapy. Clinical study of 10 cases. Neuropathological, pharmacocinetic and biochemical studies (author's transl)].
Topics: Cerebellar Diseases; Coronary Disease; Demyelinating Diseases; Endothelium; Humans; Inclusion Bodies | 1978 |
[Influence of perhexiline maleate on the electrocardiographic signs of myocardial ischemia. Ergometric study].
Topics: Coronary Disease; Drug Evaluation; Electrocardiography; Exercise Test; Female; Heart Conduction Syst | 1977 |
[Comparative studies on perhexiline, nifedipine and practolol in the light of spirometric and ergometric examinations].
Topics: Coronary Disease; Humans; Nifedipine; Perhexiline; Physical Exertion; Piperidines; Practolol; Pyridi | 1978 |
[Comparative study of the medium term use of verapamil and perhexiline in the treatment of chronic coronary insufficiency. Clinical and cycloergometric evaluation].
Topics: Adult; Aged; Chronic Disease; Coronary Disease; Electrocardiography; Exercise Test; Female; Humans; | 1978 |
[Hepatic lesions due to perhexiline maleate (author's transl)].
Topics: Aged; Chemical and Drug Induced Liver Injury; Coronary Disease; Female; Humans; Liver; Male; Middle | 1978 |
[Papillary edema and perhexiline maleate].
Topics: Aged; Coronary Disease; Female; Humans; Male; Middle Aged; Myocardial Infarction; Papilledema; Perhe | 1978 |
[Anti-arrhythmic action of perhexiline maleate in chronic coronary insufficiency].
Topics: Adult; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chronic Disease; Coronary Disease; Drug Evaluat | 1977 |
Effects of sustained isometric handgrip on ventricular systolic time intervals in patients with ischemic heart disease. Inotropic state of the left ventricle during treatment with perhexiline maleate and with propranolol.
Topics: Aged; Blood Pressure; Coronary Disease; Electrocardiography; Female; Hand; Heart Rate; Humans; Isome | 1977 |
[Spiroergometric studies following perhexiline administration in patients with coronary disease].
Topics: Adult; Coronary Disease; Hemodynamics; Humans; Middle Aged; Perhexiline; Piperidines; Spirometry | 1977 |
[Letter: Side effects of perhexiline maleate. Identification of a population with an increased risk of intolerance].
Topics: Age Factors; Coronary Disease; Female; Humans; Male; Maleates; Perhexiline; Piperidines; Sex Factors | 1975 |
[Letter: Perhexiline maleate and extrapyramidal syndrome].
Topics: Aged; Basal Ganglia Diseases; Coronary Disease; Humans; Male; Maleates; Myocardial Infarction; Perhe | 1975 |
[1st results of median term treatment with perhexiline maleate in a group of patients with severe coronary insufficiency].
Topics: Adult; Aged; Coronary Disease; Drug Evaluation; Female; Heart Rate; Humans; Male; Middle Aged; Perhe | 1975 |
Effects of perhexiline maleate on coronary flow distribution in the ischemic canine myocardium.
Topics: Animals; Coronary Circulation; Coronary Disease; Dogs; Lung; Myocardium; Oxygen Consumption; Perhexi | 1976 |
Cardiovascular effects of nitroglycerin and perhexiline in dogs with myocardial ischemia.
Topics: Animals; Coronary Circulation; Coronary Disease; Dogs; Hemodynamics; Nitroglycerin; Perhexiline | 1989 |
[Perhexiline maleate in coronary insufficiency. Clinical research].
Topics: Administration, Oral; Adult; Aged; Angina Pectoris; Coronary Disease; Electrocardiography; Female; H | 1974 |
[Letter: Weight reduction and perhexiline maleate].
Topics: Body Weight; Coronary Disease; Diuresis; Feeding and Eating Disorders; Humans; Maleates; Perhexiline | 1974 |
[Letter: Secondary but reversible effects of perhexilin administration].
Topics: Chemical and Drug Induced Liver Injury; Coronary Disease; Female; Humans; Middle Aged; Perhexiline; | 1973 |