perhexiline has been researched along with Cardiomyopathy, Hypertrophic in 4 studies
Perhexiline: 2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.
Cardiomyopathy, Hypertrophic: A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYPERTROPHY, RIGHT VENTRICULAR), frequent asymmetrical involvement of the HEART SEPTUM, and normal or reduced left ventricular volume. Risk factors include HYPERTENSION; AORTIC STENOSIS; and gene MUTATION; (FAMILIAL HYPERTROPHIC CARDIOMYOPATHY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The presence and extent of left ventricular hypertrophy (LVH) is a major determinant of symptoms in patients with hypertrophic cardiomyopathy (HCM)." | 7.01 | Randomized controlled trial of perhexiline on regression of left ventricular hypertrophy in patients with symptomatic hypertrophic cardiomyopathy (RESOLVE-HCM trial). ( Ananthakrishna, R; Binda, G; Foote, J; Horowitz, JD; Lee, SL; Mangoni, AA; Sallustio, BC; Selvanayagam, JB; Semsarian, C; Woodman, R, 2021) |
| "The presence and extent of left ventricular hypertrophy (LVH) is a major determinant of symptoms in patients with hypertrophic cardiomyopathy (HCM)." | 3.01 | Randomized controlled trial of perhexiline on regression of left ventricular hypertrophy in patients with symptomatic hypertrophic cardiomyopathy (RESOLVE-HCM trial). ( Ananthakrishna, R; Binda, G; Foote, J; Horowitz, JD; Lee, SL; Mangoni, AA; Sallustio, BC; Selvanayagam, JB; Semsarian, C; Woodman, R, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ananthakrishna, R | 1 |
| Lee, SL | 1 |
| Foote, J | 1 |
| Sallustio, BC | 1 |
| Binda, G | 1 |
| Mangoni, AA | 1 |
| Woodman, R | 1 |
| Semsarian, C | 1 |
| Horowitz, JD | 2 |
| Selvanayagam, JB | 1 |
| Gehmlich, K | 1 |
| Dodd, MS | 1 |
| Allwood, JW | 1 |
| Kelly, M | 1 |
| Bellahcene, M | 1 |
| Lad, HV | 1 |
| Stockenhuber, A | 1 |
| Hooper, C | 1 |
| Ashrafian, H | 2 |
| Redwood, CS | 1 |
| Carrier, L | 1 |
| Dunn, WB | 1 |
| Chirkov, YY | 1 |
| Abozguia, K | 1 |
| Elliott, P | 1 |
| McKenna, W | 1 |
| Phan, TT | 1 |
| Nallur-Shivu, G | 1 |
| Ahmed, I | 1 |
| Maher, AR | 1 |
| Kaur, K | 1 |
| Taylor, J | 1 |
| Henning, A | 1 |
| Watkins, H | 1 |
| Frenneaux, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Metabolic Alteration With Perhexiline Therapy in Patients With Hypertrophic Cardiomyopathy (METAL-HCM Study)[NCT00500552] | Phase 2 | 44 participants (Anticipated) | Interventional | 2006-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for perhexiline and Cardiomyopathy, Hypertrophic
| Article | Year |
|---|---|
Randomized controlled trial of perhexiline on regression of left ventricular hypertrophy in patients with symptomatic hypertrophic cardiomyopathy (RESOLVE-HCM trial).
Topics: Adult; Cardiomyopathy, Hypertrophic; Cardiovascular Agents; Double-Blind Method; Echocardiography; F | 2021 |
Metabolic modulator perhexiline corrects energy deficiency and improves exercise capacity in symptomatic hypertrophic cardiomyopathy.
Topics: Blood Glucose; Cardiomyopathy, Hypertrophic; Double-Blind Method; Energy Metabolism; Exercise Tolera | 2010 |
2 other studies available for perhexiline and Cardiomyopathy, Hypertrophic
| Article | Year |
|---|---|
Changes in the cardiac metabolome caused by perhexiline treatment in a mouse model of hypertrophic cardiomyopathy.
Topics: Animals; Cardiomyopathy, Hypertrophic; Chromatography, High Pressure Liquid; Disease Models, Animal; | 2015 |
Perhexiline and hypertrophic cardiomyopathy: a new horizon for metabolic modulation.
Topics: Cardiomyopathy, Hypertrophic; Cardiovascular Agents; Carnitine O-Palmitoyltransferase; Energy Metabo | 2010 |